Browsing by Author "Chatzi, Leda"

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  • Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: sex specific associations
    Vafeiadi, Marina, 1983-; Myridakis, Antonis; Roumeliotaki, Theano; Margetaki, Katerina; Chalkiadaki, Georgia; Dermitzaki, Eirini; Venihaki, Maria; Sarri, Katerina; Vassilaki, Maria; Leventakou, Vasiliki; Stephanou, Euripides G.; Kogevinas, Manolis; Chatzi, Leda (Frontiers, 2018)
    Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations ...
  • Association of fish consumption and mercury exposure during pregnancy with metabolic health and inflammatory biomarkers in children
    Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)
    IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
  • Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece).
    Vafeiadi, Marina, 1983-; Georgiou, Vaggelis; Chalkiadaki, Georgia; Rantakokko, Panu; Kiviranta, Hannu; Karachaliou, Marianna; Fthenou, Eleni; Venihaki, Maria; Sarri, Katerina; Vassilaki, Maria; Kyrtopoulos, Sosterios A.; Oken, Emily; Kogevinas, Manolis; Chatzi, Leda (National Institute of Environmental Health Sciences (NIEHS), 2015)
    BACKGROUND: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. OBJECTIVE: We examined the relation of in utero POPs exposure to ...
  • Associations of prenatal exposure to cadmium with child growth, obesity, and cardiometabolic traits
    Chatzi, Leda; Ierodiakonou, Despo; Margetaki, Katerina; Vafeiadi, Marina, 1983-; Chalkiadaki, Georgia; Roumeliotaki, Theano; Fthenou, Eleni; Pentheroudaki, Eirini; McConnell, Rob; Kogevinas, Manolis; Kippler, Maria (Oxford University Press, 2019)
    Prenatal cadmium exposure has been associated with impaired fetal growth; much less is known about the impact during later childhood on growth and cardiometabolic traits. To elucidate the associations of prenatal cadmium ...
  • Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: The European prospective mother-child study (NewGeneris)
    Sunyer Deu, Jordi; Pedersen, Marie; Stedingk, Hans von; Botsivali, Maria; Agramunt, Silvia; Alexander, Jan; Brunborg, Gunnar; Chatzi, Leda; Fleming, Sarah; Fthenou, Eleni; Granum, Berit; Gutzkow, Kristine B.; Hardie, Laura J.; Knudsen, Lisbeth E.; Kyrtopoulos, Sosterios A.; Mendez, Michelle A.; Merlo, Domenico Franco; Nielsen, Jeanette K.; Rydberg, Per; Segerbäck, Dan; Wright, John; Törnqvist, Margareta; Kleinjans, Jos C.; Kogevinas, Manolis; NewGeneris Consortium (National Institute of Environmental Health Sciences (NIEHS), 2012)
    Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the ...
  • Caesarean deliveries in the Mother-Child (Rhea) cohort in Crete, Greece: almost as frequent as vaginal births and even more common in first-time mothers.
    Vassilaki, Maria; Chatzi, Leda; Rasidaki, M.; Bagkeris, Emmanouil; Kritsotakis, G.; Roumeliotaki, T.; Koutis, Antonis; Philalithis, A.; Kogevinas, Manolis (Hippokratio General Hospital of Thessalonki, 2015)
    BACKGROUND: Caesarean deliveries are on the increase in Greece and around the world. The objective of the present study was to assess the frequency of planned and emergency caesarean deliveries and their socio-demographic ...
  • Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study
    Fabbri, Lorenzo; Garlantézec, Ronan; Audouze, Karine; Bustamante Pineda, Mariona; Carracedo, Ángel; Chatzi, Leda; González, Juan Ramón; Gražulevičienė, Regina; Keun, Hector C.; Lau, Chung-Ho E.; Sabidó, Eduard; Siskos, Alexandros P.; Slama, Rémy; Thomsen, Cathrine; Wright, John; Yuan, Wen Lun; Casas, Maribel; Vrijheid, Martine; Maitre, Léa (Elsevier, 2023)
    Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused ...
  • Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
    Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante Pineda, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; Kok, Theo M. de; Nawrot, Tim S.; Relton, Caroline L.; Robinson, Oliver; Roumeliotaki, Theano; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Plusquin, Michelle (BioMed Central, 2023)
    Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • Diet as a source of exposure to environmental contaminants for pregnant women and children from six european countries
    Papadopoulou, Eleni, 1985-; Haug, Line Småstuen; Sakhi, Amrit Kaur; Andrušaitytė, Sandra; Basagaña Flores, Xavier; Brantsaeter, Anne Lise; Casas Sanahuja, Maribel; Fernández-Barrés, Sílvia; Gražulevičienė, Regina; Knutsen, Helle Katrine; Maitre, Léa; Meltzer, Helle Margrete; McEachan, Rosemary R.C.; Roumeliotaki, Theano; Slama, Rémy; Vafeiadi, Marina, 1983-; Wright, John; Vrijheid, Martine; Thomsen, Cathrine; Chatzi, Leda (National Institute of Environmental Health Sciences, 2019)
    Background: Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. Objectives: Our objective was to ...
  • Dietary exposure to persistent organic pollutants during pregnancy and child health
    Papadopoulou, Eleni, 1985- (Universitat Pompeu Fabra, 2013-05-21)
    Introduction Diet is the main source of exposure to persistent organic pollutants (POPs), including dioxins and PCBs. During pregnancy the fetus is exposed to POPs which can lead to adverse health effects. The research ...
  • Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts
    Lertxundi, Nerea; Molinuevo, Amaia; Valvi, Dania; Gorostiaga, Arantxa; Balluerka, Nekane; Shivappa, Nitin; Hebert, James R.; Navarrete-Muñoz, Eva-María; Vioque, Jesus; Tardón, Adonina; Vrijheid, Martine; Roumeliotaki, Theano; Koutra, Katerina; Chatzi, Leda; Ibarluzea, Jesús (Elsevier, 2022)
    Inflammation provides a substrate for mechanisms that underlie the association of maternal diet during pregnancy with Attention Deficit-Hyperactivity Disorder (ADHD) symptoms in childhood. However, no previous study has ...
  • Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
    Contreras, Zuelma A.; Kogevinas, Manolis; Sunyer Deu, Jordi; Chatzi, Leda (European Respiratory Society, 2018)
    The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. ...
  • Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries
    Julvez, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Maitre, Léa; Philippat, Claire; Gützkow, Kristine B.; Guxens Junyent, Mònica; Evandt, Jorunn; Andrušaitytė, Sandra; Burgaleta Díaz, Miguel, 1981-; Casas Sanahuja, Maribel; Chatzi, Leda; de Castro, Montserrat; Donaire González, David; Gražulevičienė, Regina; Hernandez-Ferrer, Carles, 1987-; Heude, Barbara; McEachan, Rosie; Mon-Williams, Mark; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sakhi, Amrit Kaur; Sebastián Gallés, Núria; Slama, Rémy; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Thomsen, Cathrine; Urquiza, José M.; Vafeiadi, Marina, 1983-; Basagaña Flores, Xavier; Vrijheid, Martine (Elsevier, 2021)
    Epidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood environmental exposures and cognition. The study ...
  • Early-life environmental exposures and childhood obesity: an exposome-wide approach
    Vrijheid, Martine; Fossati, Serena; Maitre, Léa; Márquez, Sandra; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Chatzi, Leda (National Institute of Environmental Health Sciences, 2020)
    Background: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups. Objectives: ...
  • Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure
    Harskamp-van Ginkel, Margreet W.; Ierodiakonou, Despo; Margetaki, Katerina; Vafeiadi, Marina, 1983-; Karachaliou, Marianna; Kogevinas, Manolis; Vrijkotte, Tanja; Chatzi, Leda (Oxford University Press, 2020)
    Study objectives: The objective of this study was to evaluate the association between gestational sleep deprivation and childhood adiposity and cardiometabolic profile. Methods: Data were used from two population-based ...
  • Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine
    Kippler, Maria; Bottai, Mateo; Georgiou, Vaggelis; Koutra, Katerina; Chalkiadaki, Georgia; Kampouri, Mariza; Kyriklaki, Andriani; Vafeiadi, Marina, 1983-; Fthenou, Eleni; Vassilaki, Maria; Kogevinas, Manolis; Vahter, Marie; Chatzi, Leda (SpringerOpen, 2016)
    The evidence regarding a potential link of low-to-moderate iodine deficiency, selenium status, and cadmium exposure during pregnancy with neurodevelopment is either contradicting or limited. We aimed to assess the prenatal ...
  • In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants
    Vafeiadi, Marina, 1983-; Agramunt, Silvia; Papadopoulou, Eleni, 1985-; Besselink, Harrie; Mathianaki, Kleopatra; Karakosta, Polyxeni; Spanaki, Ariana; Koutis, Antonis; Chatzi, Leda; Vrijheid, Martine; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2013)
    BACKGROUND: Anogenital distance in animals is used as a measure of fetal androgen action. Prenatal exposure to dioxins and dioxin-like compounds in rodents causes reproductive changes in male offspring and decreases ...
  • Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)
    O’Callaghan-Gordo, Cristina; Kogevinas, Manolis; Pedersen, Marie; Espinosa Díaz, Ana; Tsiapa, Xristina; Romaguera Bosch, Dora; Chatzi, Leda (Springer, 2018)
    Purpose: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects ...