Browsing by Author "Chadeau-Hyam, Marc"

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  • A multivariate approach to investigate the combined biological effects of multiple exposures
    Jain, Pooja; Vineis, Paolo; Liquet, Benoît; Vlaanderen, Jelle; Bodinier, Barbara; van Veldhoven, Karin; Kogevinas, Manolis; Athersuch, Toby J.; Font-Ribera, Laia; Villanueva Belmonte, Cristina; Vermeulen, Roel; Chadeau-Hyam, Marc (BMJ Publishing Group, 2018)
    Epidemiological studies provide evidence that environmental exposures may affect health through complex mixtures. Formal investigation of the effect of exposure mixtures is usually achieved by modelling interactions, which ...
  • A systematic comparison of statistical methods to detect interactions in exposome-health associations
    Barrera Gómez, Jose; Agier, Lydiane; Portengen, Lützen; Chadeau-Hyam, Marc; Giorgis-Allemand, Lise; Siroux, Valérie; Robinson, Oliver; Vlaanderen, Jelle; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Vineis, Paolo; Vrijheid, Martine; Vermeulen, Roel; Slama, Rémy; Basagaña Flores, Xavier (BioMed Central, 2017)
    There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human ...
  • Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease: The EU EXPANSE project
    Vlaanderen, Jelle; de Hoogh, Kees; Hoek, Gerard; Peters, Annette; Probst-Hensch, Nicole; Scalbert, Augustin; Melén, Erik; Tonne, Cathryn; de Wit, G. Ardine; Chadeau-Hyam, Marc; Katsouyanni, Klea; Esko, Tõnu; Jongsma, Karin R.; Vermeulen, Roel (Wolters Kluwer (LWW), 2021)
    By 2030, more than 80% of Europe's population will live in an urban environment. The urban exposome, consisting of factors such as where we live and work, where and what we eat, our social network, and what chemical and ...
  • DNA methylation and exposure to ambient air pollution in two prospective cohorts
    Plusquin, Michelle; Sayols, Sergi; Chadeau-Hyam, Marc (Elsevier, 2017)
    Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further ...
  • Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies
    van Veldhoven, Karin; Kiss, Agneta; Keski-Rahkonen, Pekka; Robinot, Nivonirina; Scalbert, Augustin; Cullinan, Paul; Chung, Kian Fan; Collins, Peter; Sinharay, Rudy; Barratt, Benjamin M.; Nieuwenhuijsen, Mark J.; Ambros, Albert; Carrasco Turigas, Glòria; Vlaanderen, Jelle; Vermeulen, Roel; Portengen, Lützen; Kyrtopoulos, Sosterios A.; Ponzi, Erica; Chadeau-Hyam, Marc; Vineis, Paolo (Elsevier, 2019)
    Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford ...
  • Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks
    Krauskopf, Julian; van Veldhoven, Karin; Chadeau-Hyam, Marc; Vermeulen, Roel; Carrasco Turigas, Glòria; Nieuwenhuijsen, Mark J.; Vineis, Paolo; Kok, Theo M. de; Kleinjans, Jos C. (Elsevier, 2019)
    Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer, pulmonary, cardiovascular and neurodegenerative diseases, and ...
  • State-of-the-art methods for exposure-health studies: Results from the exposome data challenge event
    Maitre, Léa; Guimbaud, Jean-Baptiste; Warembourg, Charline; Güil Oumrait, Núria; Petrone, Paula M.; Chadeau-Hyam, Marc; Vrijheid, Martine; Basagaña Flores, Xavier; González, Juan Ramón; Exposome Data Challenge Participant Consortium (Elsevier, 2022)
    The exposome recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological factors for disease. However, challenges ...