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Browsing by Author "Cerutti, Andrea, 1965-"
Now showing items 1-19 of 19
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Bascones Gleave, Sabrina, 1985- (Universitat Pompeu Fabra, 2016-12-20)The spleen contains a unique subset of innate-like marginal zone (MZ) B cells that rapidly mount protective antibody responses to invasive encapsulated bacteria. Here we show that human splenic MZ B cells also mount ...
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Magri, Giuliana, 1978-; Cerutti, Andrea, 1965- (Nature Publishing Group, 2015)The mechanisms whereby the gut mucosa tolerates trillions of commensal bacteria without developing inflammation remain poorly understood. A recent Science article reveals that gut innate lymphoid cells constrain inflammatory ...
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Magri, Giuliana, 1978-; Pybus Oliveras, Marc, 1985-; Sintes, Jordi; Lligé, David; Segura-Garzón, Daniel; Bascones Gleave, Sabrina, 1985-; Yeste, Ada; Grasset, Emilie K.; Gutzeit, Cindy; Uzzan, Mathieu; Ramanujam, Meera; van Zelm, Menno C.; Albero-González, Raquel; Vazquez de las Heras, Ivonne; Iglesias, Mar; Serrano Figueras, Sergi; Márquez, Lucía; Mercade, Elena; Mehandru, Saurabh; Cerutti, Andrea, 1965- (Elsevier, 2017)Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant in humans than mice and clonally related to a large ...
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Comerma Blesa, Laura, 1983- (Universitat Pompeu Fabra, 2016-07-12)We found that IgM+IgD- memory (ME-M) B cells formed a large reservoir of intestinal antigen-selected IgM+ lymphocytes distinct from antigen-naïve IgM+ lymphocytes. Human ME-M B cells colonized the intestine early in life, ...
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Neuman, Hadas; Arrouasse, Jessica; Kedmi, Meirav; Cerutti, Andrea, 1965-; Magri, Giuliana, 1978-; Mehr, Ramit (Frontiers, 2022)Somatic hypermutation (SHM) is an important diversification mechanism that plays a part in the creation of immune memory. Immunoglobulin (Ig) variable region gene lineage trees were used over the last four decades to model ...
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Livanos, Alexandra E.; Cerutti, Andrea, 1965-; Mehandru, Saurabh (Elsevier, 2021)Background & aims: Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance. ...
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Sintes, Jordi; Serrano Figueras, Sergi; Lloreta Trull, Josep, 1958-; Cerutti, Andrea, 1965- (Nature Publishing Group, 2017)Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte ...
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Grasset, Emilie K.; Cerutti, Andrea, 1965- (Rockefeller University Press, 2020)In this issue, Kabbert et al. (https://doi.org/10.1084/jem.20200275) show that intestinal antibodies from healthy subjects or patients with Crohn's disease cross-target diverse but distinct communities of the gut microbiota ...
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Cerutti, Andrea, 1965- (Universitat Pompeu Fabra, 2013-07-19)Immunoglobulin (Ig) diversification is essential for the generation of protective immune responses against intruding microbes. B cells require cognate interaction with T cells to generate protective antibodies, although ...
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Magri, Giuliana, 1978-; Cerutti, Andrea, 1965- (Elsevier, 2015)Innate lymphoid cells (ILCs) constitute a heterogeneous family of effector lymphocytes of the innate immune system that mediate lymphoid organogenesis, tissue repair, immunity and inflammation. The initial view that ILCs ...
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Gentile, Maurizio, 1981- (Universitat Pompeu Fabra, 2014-09-19)The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that mount rapid protective antibody responses to polysaccharides and lipids from bloodborne viruses and bacteria. These antigens activate MZ ...
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Cassis, Linda, 1977- (Universitat Pompeu Fabra, 2016-12-07)Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation of a steady-state ...
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Campos Mata, Leire de, 1991-; Tejedor Vaquero, Sonia, 1988-; Tachó-Piñot, Roser; Piñero González, Janet, 1977-; Grasset, Emilie K.; Arrieta Aldea, Itziar; Rodrigo Melero, Natalia; Carolis, Carlo; Horcajada Gallego, Juan Pablo; Cerutti, Andrea, 1965-; Villar García, Judit; Magri, Giuliana, 1978- (Wiley Open Access, 2021)Objectives: SARS-CoV-2 infection induces virus-reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus-specific naïve B cells and their impact ...
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Barra Quaglia, Carolina M., 1982- (Universitat Pompeu Fabra, 2014-10-06)Los sinusoides del bazo humano promueven la lenta percolación de la sangre, favoreciendo la captura de antígeno por los fagocitos y linfocitos del sistema inmune local. Estratégicamente posicionadas delimitando los vasos, ...
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García-Carmona, Yolanda; Ting, Adrian T.; Radigan, Lin; Athuluri Divakar, Sai Krishna; Chávez, Jose; Meffre, Eric; Cerutti, Andrea, 1965-; Cunningham-Rundles, Charlotte (Frontiers, 2018)TACI signals activate B cell proliferation, isotype switch and antibody production in both normal immunity and autoimmune states. In contrast to murine TACI, the human TACI gene undergoes alternative splicing to produce ...
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Perdiguero, Pedro; Martín-Martín, Alba; Benedicenti, Ottavia; Díaz-Rosales, Patricia; Morel, Esther; Muñoz-Atienza, Estefanía; García-Flores, Mónica; Simón, Rocío; Soleto, Irene; Cerutti, Andrea, 1965-; Tafalla, Carolina (Elsevier, 2019)Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM- plasmablasts ...
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Bogaert, Delfien J.A.; De Bruyne, Marieke; Debacker, Veronique; Depuydt, Pauline; De Preter, Katleen; Bonroy, Carolien; Philippé, Jan; Bordon, Victoria; Lambrecht, Bart N.; Kerre, Tessa; Cerutti, Andrea, 1965-; Vermaelen, Karim Y.; Haerynck, Filomeen; Dullaers, Melissa (Ferrata Storti Foundation, 2017)The etiology of primary antibody deficiencies is largely unknown. Beside rare monogenic forms, the majority of cases seem to have a more complex genetic basis. Whereas common variable immunodeficiency has been investigated ...
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Tejedor Vaquero, Sonia, 1988-; Campos Mata, Leire de, 1991-; Ramada Rodilla, José María, 1961-; Díaz, Pilar; Navarro-Barriuso, Juan; Ribas-Llauradó, Clara; Rodrigo Melero, Natalia; Carolis, Carlo; Cerutti, Andrea, 1965-; Gimeno Martínez, Ramón; Magri, Giuliana, 1978- (Frontiers Media, 2021)mRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of vaccine-induced antibody responses to the ...
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Chorny, Alejo; Sintes, Jordi; Cassis, Linda, 1977-; Puga, Irene; Cerutti, Andrea, 1965- (Rockefeller University Press, 2016)Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 ...
Now showing items 1-19 of 19
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