Browsing by Author "Castellví Fernández, Quim"

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  • 3D Assessment of irreversible electroporation treatments in vegetal models
    Castellví Fernández, Quim; Banús Cobo, Jaume; Ivorra Cano, Antoni, 1974- (Springer, 2015)
    Ablative techniques based on irreversible elec-troporation (IRE) have emerged as an effective cancer thera-py. In these treatments electrical pulses are delivered in order to induce irrecoverable damage to the cell membranes, ...
  • A versatile multilevel converter platform for cancer treatment using irreversible electroporation
    Sarnago, Héctor; Lucía, Óscar; Naval, Alejandro; Burdío, José M.; Castellví Fernández, Quim; Ivorra Cano, Antoni, 1974- (Institute of Electrical and Electronics Engineers (IEEE), 2016)
    Electroporation is an effective technique based on applying an electric field to cells, commonly used to increase the effectivity of drug and gene delivery. When the applied electric field is ...
  • Avoiding neuromuscular stimulation in liver irreversible electroporation using radiofrequency electric fields
    Castellví Fernández, Quim; Mercadal, Borja; Moll, Xavier; Fondevila, Dolors; Andaluz, Anna; Ivorra Cano, Antoni, 1974- (Institute of Physics (IOP), 2018)
    Electroporation based treatments typically consist in applying high voltage dc pulses. As an undesired side effect, these dc pulses cause electrical stimulation of excitable tissues such as motor nerves. In the present in ...
  • Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments
    Trujillo Guillén, Macarena; Castellví Fernández, Quim; Burdío Pinilla, Fernando; Ivorra Cano, Antoni, 1974-; Andaluz, Anna; Sanchez Velazquez Patricia; Berjano, Enrique J. (Taylor & Francis (Routledge), 2013)
    Purpose: To assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood ...
  • Dynamics of cell death after conventional IRE and H-FIRE treatments
    Mercadal, Borja; Beitel White, Natalie; Aycock, Kenneth N.; Castellví Fernández, Quim; Davalos, Rafael Vidal; Ivorra Cano, Antoni, 1974- (Springer, 2020)
    High-frequency irreversible electroporation (H-FIRE) has emerged as an alternative to conventional irreversible electroporation (IRE) to overcome the issues associated with neuromuscular electrical stimulation that appear ...
  • Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model: Preliminary results on differential conductivity
    Pañella Vilamú, Clara, 1987-; Castellví Fernández, Quim; Moll, Xavier; Quesada Diez, Rita; Villanueva, Alberto; Iglesias, Mar; Naranjo‐Hans, Dolores; Sánchez Velázquez, Patricia, 1985-; Andaluz, Anna; Grande Posa, Luís; Ivorra Cano, Antoni, 1974-; Burdío Pinilla, Fernando (De Gruyter, 2017)
    Background. Spread hepatic tumours are not suitable for treatment either by surgery or conventional ablation methods. The aim of this study was to evaluate feasibility and safety of selectively ...
  • In vivo demonstration of injectable microstimulators based on charge-balanced rectification of epidermically applied currents
    Ivorra Cano, Antoni, 1974-; Becerra Fajardo, Laura; Castellví Fernández, Quim (Institute of Physics (IOP), 2015)
    It is possible to develop implantable microstimulators whose actuation principle is based on rectification of high frequency (HF) current bursts supplied through skin electrodes. This has been demonstrated previously by ...
  • Injectable sensors based on passive rectification of volume-conducted currents
    Malik, Shahid; Castellví Fernández, Quim; Becerra Fajardo, Laura; Tudela Pi, Marc; García Moreno, Aracelys; Shojaei Baghini, Maryam; Ivorra Cano, Antoni, 1974- (Institute of Electrical and Electronics Engineers (IEEE), 2020)
    Sensing implants that can be deployed by catheterization or by injection are preferable over implants requiring invasive surgery. However, present powering methods for active implants and present interrogation methods for ...
  • Irreversible electroporation of the liver: is there a safe limit to the ablation volume?
    Sánchez-Velázquez, Joan; Castellví Fernández, Quim; Villanueva, Alberto; Quesada Diez, Rita; Pañella Vilamú, Clara, 1987-; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Trujillo Guillén, Macarena; Burdío, José M.; Berjano, Enrique J.; Grande Posa, Luís; Ivorra Cano, Antoni, 1974-; Burdío Pinilla, Fernando (Nature Publishing Group, 2016-04-01)
    Irreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim is to assess its safety and feasibility when a large portion of liver is ablated. ...
  • Long-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis
    Ivorra Cano, Antoni, 1974-; Sánchez Velázquez, Patricia, 1985-; Castellví Fernández, Quim; Villanueva, Alberto; Iglesias Coma, Mar; Quesada Diez, Rita; Pañella Vilamú, Clara, 1987-; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Burdío, José M.; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Publishing Group, 2017)
    Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with ...
  • Mesures de bio-impédance pour l’electroporation
    Castellví Fernández, Quim (Société de l'électricité, de l'électronique et des technologies de l'information et de la communication (SEE), 2014)
    Les mesures de bio-impédance sont utilisées pour déterminer les propriétés et la physiologie des tissus biologiques. Par ailleurs, le phénomène d'électroporation provoque une variation dans les propriétés électriques du ...
  • Modeling liver electrical conductivity during hypertonic injection
    Castellví Fernández, Quim; Sánchez Velázquez, Patricia, 1985-; Moll, Xavier; Berjano, Enrique J.; Andaluz, Anna; Burdío Pinilla, Fernando; Bijnens, Bart; Ivorra Cano, Antoni, 1974- (Wiley, 2018)
    Metastases in the liver frequently grow as scattered tumor nodules which neither can be removed by surgical resection nor focally ablated. Previously, we have proposed a novel technique based on irreversible electroporation ...
  • Non-focal non-thermal electrical methods for cancer treatment
    Castellví Fernández, Quim (Universitat Pompeu Fabra, 2018-07-06)
    Most physical ablation modalities for cancer treatment are focal and are based on thermal damage. Despite their regular clinical use as an alternative to surgical resection, their thermal principle of operation entails ...
  • Selective electroporation of liver tumor nodules by means of hypersaline infusion: a feasibility study
    Castellví Fernández, Quim; Sánchez-Velázquez, Joan; Berjano, Enrique J.; Burdío Pinilla, Fernando; Ivorra Cano, Antoni, 1974- (Springer, 2015)
    Spread tumors in liver are not suitable to be treated with local treatments, such as conventional surgery or radiofrequency ablation, thus entailing a poor prognosis. Electroporation-based therapies imply the delivery of ...
  • Tumor growth delay by adjuvant alternating electric fields which appears non-thermally mediated
    Castellví Fernández, Quim; Ginestà, Mireia M.; Capellá, Gabriel; Ivorra Cano, Antoni, 1974- (Elsevier, 2015)
    Delivery of the so-called Tumor Treatment Fields (TTFields) has been proposed as a cancer/ntherapy. These are low magnitude alternating electric fields at frequencies from 100 to 300 kHz/nwhich are applied continuously in ...
  • XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
    Domenjó Vila, Eva, 1993-; Casella, Valentina, 1991-; Iwabuchi, Ryutaro; Fossum, Even; Pedragosa Marín, Mireia, 1988-; Castellví Fernández, Quim; Cebollada Rica, Paula; Kaisho, Tsuneyasu; Terahara, Kazutaka; Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Elsevier, 2023)
    The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized. Using ...