Browsing by Author "Castells, Antoni"

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  • Alvarez-Urturi, Ana Cristina; Fernández-Esparrach, Gloria; Ibáñez Zafón, Inés Ana; Rodríguez De Miguel, Cristina; Dedeu Cusco, Josep Maria; Bessa Caserras, Xavier; Córdova, Henry; Pellisé, Maria; Balaguer, Francesc; Ginés, Angels; Barranco Priego, Luis Eugenio; Araujo, Isis K.; Andreu García, Montserrat; Llach, Josep; Castells, Antoni; González-Suarez, Begoña (Hindawi, 2017)
    Background. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. Methods. ...
  • Buron Pust, Andrea; Auge, Josep M.; Sala Serra, Maria; Román, Marta; Castells, Antoni; Macià Guilà, Francesc Assís; Comas Serrano, Mercè; Guiriguet, Carolina; Bessa Caserras, Xavier; Castells, Xavier; PROCOLON research group (Public Library of Science (PLoS), 2017)
    BACKGROUND: Screening with faecal occult blood tests reduces colorectal cancer-related mortality; however, age, sex and socioeconomic factors affect screening outcomes and could lead to unequal mortality benefits. The aim ...
  • Murcia, Oscar; Juárez, Míriam; Rodríguez-Soler, María; Hernández-Illán, Eva; Giner-Calabuig, Mar; Alustiza, Miren; Egoavil, Cecilia; Castillejo, Adela; Alenda, Cristina; Barbera, Victor Manuel; Mangas-Sanjuan, Carolina; Yuste, Ana; Bujanda, Luis; Clofent, Juan; Andreu García, Montserrat; Castells, Antoni; Llor, Xavier; Zapater, Pedro; Jover, Rodrigo (Public Library of Science (PLoS), 2018)
    OBJECTIVE: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate ...
  • Carot, Laura; Castells, Antoni; Hernández Rodríguez, Cristina; Alvarez-Urturi, Ana Cristina; Balaguer, Francesc; Lanas, Angel; Cubiella, Joaquı́n; Tasende, Jose D.; Jover, Rodrigo; Hernandez, Vicent; Carballo, Fernando; Bujanda, Luis; Quintero, Enrique; Andreu García, Montserrat; Bessa Caserras, Xavier; ColonPrev study (SAGE Publications, 2018)
    BACKGROUND: The diagnostic yield of the faecal immunochemical test and sigmoidoscopy in detecting proximal serrated polyps in a colorectal cancer screening programme has not been fully assessed. AIM: We determined the ...
  • Hamaya, Yasushi; Guarinos, Carla; Tseng-Rogenski, Stephanie S.; Iwaizumi, Moriya; Das, Ritabrata; Jover, Rodrigo; Castells, Antoni; Llor, Xavier; Andreu García, Montserrat; Carethers, John M. (Public Library of Science, 2015)
    Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) is a genetic signature found in up to 60% of colorectal cancers (CRCs) that is caused by somatic dysfunction of the DNA mismatch repair (MMR) ...
  • Castillejo, Adela; Guarinos, Carla; Martínez Canto, Ana; Barbera, Victor Manuel; Egoavil, Cecilia; Castillejo, Maria Isabel; Pérez Carbonell, Lucía; Sánchez Heras, Ana Beatriz; Segura, Ángel; Ochoa, Enrique; Lazaro, Rafael; Ruiz Ponte, Clara; Bujanda, Luis; Andreu García, Montserrat; Castells, Antoni; Carracedo, Ángel; Llor, Xavier; Clofent, Juan; Alenda, Cristina; Paya, Artemio; Jover, Rodrigo; Soto, José Luis (BioMed Central, 2011)
    Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS ...
  • Fernández-Rozadilla, C.; Álvarez-Barona, M.; Quintana, I.; López-Novo, A.; Amigo, J.; Cameselle-Teijeiro, J.M.; Roman, E.; Gonzalez, D.; Llor, Xavier; Llor, Xavier; Bujanda, Luis; Bessa Caserras, Xavier; Jover, Rodrigo; Balaguer, Francesc; Castells, Antoni; Castellví Bel, Sergi; Capellá, Gabriel; Carracedo, Ángel; Valle, L.; Ruiz Ponte, Clara (Nature Research, 2021)
    Colorectal cancer (CRC) is a complex disease that can be caused by a spectrum of genetic variants ranging from low to high penetrance changes, that interact with the environment to determine which individuals will develop ...
  • Abulí, Anna; Castells, Antoni; Bujanda, Luis; Lozano, Juan José; Bessa Caserras, Xavier; Hernández Rodríguez, Cristina; Alvarez Urturi, Cristina; Pellisé, Maria; Esteban Jurado, Clara; Hijona, Elizabeth; Buron Pust, Andrea; Macià Guilà, Francesc Assís; Grau, Jaume; Guayta, Rafael; Castellví Bel, Sergi; Andreu García, Montserrat; PROCOLON research group (Public Library of Science, 2016)
    BACKGROUND: Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM: To determine if these genetic variants are associated also with adenoma susceptibility and may improve ...
  • Guiriguet, Carolina; Pera, Guillem; Castells, Antoni; Toran, Pere; Grau, Jaume; Rivero, Irene; Buron Pust, Andrea; Macià Guilà, Francesc Assís; Vela-Vallespín, Carmen; Vilarrubí-Estrella, Mercedes; Marzo-Castillejo Mercedes (BioMed Central, 2017)
    BACKGROUND: There is controversy regarding how comorbidity impacts on colorectal cancer screening, especially in the context of organised programmes. The aim of this study is to assess the effect of comorbidities on ...
  • Kandimalla, K.; Linnekamp, J.F.; Van Hooff, S.; Castells, Antoni; Llor, Xavier; Andreu García, Montserrat; Jover, Rodrigo; Goel, A.; Medema, J.P. (Nature Publishing Group, 2017)
    Stage II colon cancer (CC) still remains a clinical challenge with patient stratification for adjuvant therapy (AT) largely relying on clinical parameters. Prognostic biomarkers are urgently needed for better stratification. ...
  • Esteban Jurado, Clara; Garre, Pilar; Vila, Maria; Lozano, Juan José; Pristoupilova, Anna; Beltrán, Sergi; Abulí, Anna; Muñoz, Jenifer; Balaguer, Francesc; Ocaña, Teresa; Castells, Antoni; Piqué, Josep M.; Carracedo, Ángel; Ruiz Ponte, Clara; Bessa Caserras, Xavier; Andreu García, Montserrat; Bujanda, Luis; Caldés, Trinidad; Castellví Bel, Sergi (Baishideng Publishing Group, 2014)
    Colorectal cancer (CRC) is one of the most frequent neoplasms and an important cause of mortality in the developed world. This cancer is caused by both genetic and environmental factors although 35% of the variation in CRC ...
  • Pablo Fontecha, Verónica; Hernández-Illán, Eva; Reparaz, Andrea; Asensio Juan, Elena; Morata, Jordi; Tonda, Raúl; Lahoz, Sara; Parra, Carolina; Lozano, Juan José; García-Heredia, Anabel; Martínez-Roca, Alejandro; Beltran, Sergi; Balaguer, Francesc; Jover, Rodrigo; Castells, Antoni; Trullàs, Ramón; Podlesniy, Petar; Camps-Puchadas, Jordi (Nature Research, 2023)
    Somatic single-nucleotide variants (SNVs) occur every time a cell divides, appearing even in healthy tissues at low frequencies. These mutations may accumulate as neutral variants during aging, or eventually, promote the ...
  • Sánchez-Tilló, Ester; Pedrosa, Leire; Vila, Ingrid; Chen, Yongxu; Gyorffy, Balázs; Sánchez-Moral, Lidia; Siles, Laura; Lozano, Juan José; Esteve-Codina, Anna; Darling, Douglas S.; Cuatrecasas, Miriam; Castells, Antoni; Maurel, Joan; Postigo, Antonio (American Society for Clinical Investigation, 2023)
    Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal transition (EMT) and is associated with worse ...
  • Bustos, Aurelia; Payá, Artemio; Torrubia, Andrés; Jover, Rodrigo; Llor, Xavier; Bessa Caserras, Xavier; Castells, Antoni; Carracedo, Ángel; Alenda, Cristina (MDPI, 2021)
    The prediction of microsatellite instability (MSI) using deep learning (DL) techniques could have significant benefits, including reducing cost and increasing MSI testing of colorectal cancer (CRC) patients. Nonetheless, ...

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