Browsing by Author "Castanho, Miguel A.R.B."

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  • Cavaco, Marco; Frutos, Silvia; Oliete, Paula; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Vila-Perelló, Miquel; Neves, Vera (American Chemical Society (ACS), 2021)
    The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative therapeutic strategies. The use of ...
  • Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (MDPI, 2021)
    Breast cancer (BC) is the most commonly diagnosed cancer in women and one of the most common causes of cancer-related deaths. Despite intense research efforts, BC treatment still remains challenging. Improved drug development ...
  • Cavaco, Marco; Valle, Javier; Flores, Isabel; Andreu Martínez, David; Castanho, Miguel A.R.B. (Wiley, 2021)
    Proteolytic instability is a critical limitation for peptide-based products. Although significant efforts are devoted to stabilize sequences against proteases/peptidases in plasma/serum, such approaches tend to be rather ...
  • Andreu Martínez, David; Miguel Freire, João; Veiga, Anna; Conceiçao, Thaís M.; Kowalczyk, Wioleta; Mohana-Borges, Ronaldo; Santos, Nuno C.; Da Poian, Andrea T.; Castanho, Miguel A.R.B. (Public Library of Science (PLoS), 2014)
    Supercharged proteins are a recently identified class of proteins that have the ability to efficiently deliver functional macromolecules into mammalian cells. They were first developed as bioengineering products, but were ...
  • Pérez-Peinado, Clara, 1991-; Almeida Dias, Susana; Domingues, Marco M.; Benfield, Aurélie H.; Miguel Freire, João; Rádis-Baptista, Gandhi; Gaspar, Diana; Castanho, Miguel A.R.B.; Craik, David J.; Troeira Henriques, Sónia; Salomé Veiga, Ana; Andreu Martínez, David (American Society for Biochemistry and Molecular Biology (ASBMB), 2018)
    Crotalicidin (Ctn), a cathelicidin-related peptide from the venom of a South American rattlesnake, possesses potent antimicrobial, antitumor, and antifungal properties. Previously, we have shown that its C-terminal fragment, ...
  • Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Silva, Rúben D.M.; Gano, Lurdes; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (BioMed Central, 2024)
    Blood-brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are poorly characterized. Currently, their development ...
  • Miguel Freire, João; Gaspar, Diana; García de la Torre, Beatriz; Veiga, Ana Salomé; Andreu Martínez, David; Castanho, Miguel A.R.B. (Elsevier, 2015)
    Despite the intensive study of antibiotic-induced bacterial permeabilization, its kinetics and molecular mechanism remain largely elusive. A new methodology that extends the concept of the live-dead assay in flow cytometry ...
  • Dias, Susana A.; Miguel Freire, João; Pérez-Peinado, Clara, 1991-; Domingues, Marco M.; Gaspar, Diana; Vale, Nuno; Gomes, Paula; Andreu Martínez, David; Henriques, Sónia T.; Castanho, Miguel A.R.B.; Veiga, Ana Salomé (Frontiers, 2017)
    The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. ...
  • Gallo, María, 1989-; Moreno, Estefanía; Defaus, Sira; Ortega Alvaro, Antonio; Gonzalez, Angel; Robledo, Patricia, 1958-; Cavaco, Marco; Neves, Vera; Castanho, Miguel A.R.B.; Casadó, Vicent; Pardo Carrasco, Leonardo; Maldonado, Rafael, 1961-; Andreu Martínez, David (American Chemical Society (ACS), 2021)
    The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation, however, also causes cognitive impairment via the serotonin ...
  • Mendonça, Diogo A.; Bakker, Mariët; Cruz-Oliveira, Christine; Neves, Vera; Jiménez, Maria Angeles; Defaus, Sira; Cavaco, Marco; Salomé Veiga, Ana; Cadima-Couto, Iris; Castanho, Miguel A.R.B.; Andreu Martínez, David; Todorovski, Toni (American Chemical Society (ACS), 2021)
    Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive ...
  • Dias, Susana A.; Pinto, Sandra N.; Silva-Herdade, Ana S.; Cavaco, Marco; Neves, Vera; Tavares, Luís; Oliveira, Manuela; Andreu Martínez, David; Coutinho, Ana; Castanho, Miguel A.R.B.; Salomé Veiga, Ana (American Chemical Society (ACS), 2023)
    The formation of biofilms is a common virulence factor that makes bacterial infections difficult to treat and a major human health problem. Biofilms are bacterial communities embedded in a self-produced matrix of extracellular ...
  • Todorovski, Toni; Mendonça, Diogo A.; Fernandes-Siqueira, Lorena O.; Cruz-Oliveira, Christine; Valle, Javier; Cavaco, Marco; Limas, Fernanda I. V.; Neves, Vera; Cadima-Couto, Iris; Defaus, Sira; Salomé Veiga, Ana; Da Poian, Andrea T.; Castanho, Miguel A.R.B.; Andreu Martínez, David (MDPI, 2022)
    Viral disease outbreaks affect hundreds of millions of people worldwide and remain a serious threat to global health. The current SARS-CoV-2 pandemic and other recent geographically- confined viral outbreaks (severe acute ...
  • Oliveira, Filipa D.; Cavaco, Marco; Figueira, Tiago N.; Valle, Javier; Neves, Vera; Andreu Martínez, David; Gaspar, Diana; Castanho, Miguel A.R.B. (Wiley, 2022)
    The incidence of metastatic breast cancer (MBC) is increasing and the therapeutic arsenal available to fight it is insufficient. Brain metastases, in particular, represent a major challenge for chemotherapy as the impermeable ...
  • Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)
    Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
  • Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Gano, Lurdes; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Elsevier, 2024)
    Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of commonly targeted receptors. Unspecific chemotherapy is currently the main therapeutic option, with poor results. Another major ...
  • Cavaco, Marco; Pérez-Peinado, Clara, 1991-; Valle, Javier; Silva, Rúben D.M.; Correia, João D.G.; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (Frontiers, 2020)
    The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These ...

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