Browsing by Author "Casal, José Ignacio"

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  • Casagolda, David; Valle Pérez, Beatriz del; Valls, Gabriela; Lugilde, Ero; Vinyoles, Meritxell; Casado Vela, Juan; Solanas, Guiomar; Batlle Gómez, Eduard; Reynolds, Albert B.; Casal, José Ignacio; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2010)
    p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1ε ...
  • Peláez García, Alberto; Barderas, Rodrigo; Batlle Gómez, Raquel; Viñas Castells, Rosa, 1985-; Bartolome, Rubén A.; Torres, Sofía; Mendes, Marta; López Lucendo, María; Mazzolini, Rocco; Bonilla, Félix; García de Herreros, Antonio; Casal, José Ignacio (American Society for Biochemistry and Molecular Biology (ASBMB), 2015)
    Adipogenesis requires a differentiation program driven by multiple transcription factors, where PPARγ and C/EBPα play a central role. Recent findings indicate that Snail inhibits adipocyte differentiation in 3T3-L1 and ...
  • Herrera, Mercedes; Herrera, Alberto; Domínguez, Gemma; Silva, Javier; García, Vanesa; García, Jose M.; Gómez, Irene; Soldevilla, Beatriz; Muñoz, Concepción; Provencio, Mariano; Campos Martin, Yolanda; García de Herreros, Antonio; Casal, José Ignacio; Bonilla, Félix; Peña, Cristina (Japanese Cancer Association, 2013)
    Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts ...
  • Peláez García, Alberto; Barderas, Rodrigo; Mendes, Marta; López Lucendo, María; Sanchez, J.C.; García de Herreros, Antonio; Casal, José Ignacio (Elsevier, 2015)
    The transcription factor (TF) Snail1 is a major inducer of the epithelial-mesenchymal transition (EMT) during embryonic development and cancer progression. Ectopic expression of Snail in murine mesenchymal stem cells (mMSC) ...
  • Peláez García, Alberto; Barderas, Rodrigo; Torres, Sofía; Teixidó, Joaquín; Bonilla, Félix; García de Herreros, Antonio; Hernández-Varas, Pablo; Casal, José Ignacio (Public Library of Science (PLoS), 2013)
    Fibroblast growth factor receptor 4 (FGFR4) is vital in early development and tissue repair. FGFR4 expression levels are very restricted in adult tissues, except in several solid tumors including colorectal cancer, which ...
  • Campos, Alex; Díaz, Ramón; Martínez Bartolomé, Salvador; Sierra, Jose; Gallardo, Oscar; Sabidó Aguadé, Eduard, 1981-; López Lucendo, María; Casal, José Ignacio; Pasquarello, Carla; Scherl, Alexander; Chiva, Cristina; Borrás, Eva; Odena, Antonia; Elortza, Félix; Azkargorta, Mikel; Ibarrola, Nieves; Canals, Francesc; Albar, Juan Pablo; Oliveira, Eliandre (Elsevier, 2015)
    Proteomic technologies based on mass spectrometry (MS) have greatly evolved in the past years, and nowadays it is possible to routinely identify thousands of peptides from complex biological samples in a single LC-MS/MS ...
  • Larriba, María Jesús; Casado Vela, Juan; Pendás Franco, Natalia; Peña, Raúl; García de Herreros, Antonio; Berciano, María Teresa; Lafarga, Miguel; Casal, José Ignacio; Muñoz, Alberto (Public Library of Science (PLoS), 2010)
    Background: The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT), a process responsible for the acquisition of invasiveness during tumorigenesis. Several transcriptomic studies have ...
  • Alba-Castellón, Lorena; Batlle, Raquel; Francí, Clara; Fernández Aceñero, María Jesús; Mazzolini, Rocco; Peña, Raúl; Loubat, Jordina; Alameda Quitllet, Francisco; Rodríguez, Rufo; Curto, Josué; Albanell, Joan; Muñoz, Alberto; Bonilla, Félix; Casal, José Ignacio; Rojo, Federico; García de Herreros, Antonio (Elsevier, 2014)
    Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of ...

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