Browsing by Author "Carmona, Mercè"

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  • Encinar del Dedo, Javier; Gabrielli, Natalia, 1978-; Carmona, Mercè; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science, 2015)
    Iron is an essential cofactor, but it is also toxic at high levels. In Schizosaccharomyces pombe, the sensor glutaredoxin Grx4 guides the activity of the repressors Php4 and Fep1 to mediate a complex transcriptional response ...
  • Paulo Mirasol, Esther, 1984-; García Santamarina, Sarela, 1978-; Calvo, Isabel A.; Carmona, Mercè; Boronat i Llop, Susanna, 1965-; Domènech, Alba; Ayté del Olmo, José; Hidalgo Hernando, Elena (Wiley-Blackwell, 2014)
    The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion ...
  • Marquina, Maribel; Lambea, Eva; Carmona, Mercè; Sánchez-Marinas, Marta; López-Aviles, Sandra; Ayté del Olmo, José; Hidalgo Hernando, Elena; Aligué, Rosa (Nature Research, 2022)
    The fission yeast mitogen-activated kinase (MAPK) Sty1 is essential for cell survival in response to different environmental insults. In unstimulated cells, Sty1 forms an inactive ternary cytoplasmatic complex with the ...
  • Salat Canela, Clàudia; Paulo Mirasol, Esther, 1984-; Sánchez Mir, Laura; Carmona, Mercè; Ayté del Olmo, José; Oliva Miguel, Baldomero; Hidalgo Hernando, Elena (American Society for Biochemistry and Molecular Biology (ASBMB), 2017)
    Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the ...
  • Boronat i Llop, Susanna, 1965-; Domènech, Alba; Carmona, Mercè; García Santamarina, Sarela, 1978-; Bañó, M. Carmen; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2017)
    The thioredoxin and glutaredoxin pathways are responsible of recycling several enzymes which undergo intramolecular disulfide bond formation as part of their catalytic cycles such as the peroxide scavengers peroxiredoxins ...
  • Zuin, Alice, 1978-; Carmona, Mercè; Morales Ivorra, Isabel; Gabrielli, Natalia, 1978-; Vivancos Prellezo, Ana; Ayté del Olmo, José; Hidalgo Hernando, Elena (Nature Publishing Group, 2010)
    Either calorie restriction, loss of function of the nutrient-dependent PKA or TOR/SCH9 pathways, or activation of stress defences improves longevity in different eukaryotes. However, the molecular links between glucose ...
  • Fernández Vázquez, Jorge; Vargas Pérez, Itzel; Sansó Martínez, Miriam, 1979-; Buhne, Karin; Carmona, Mercè; Paulo Mirasol, Esther, 1984-; Hermand, Damien; Rodríguez Gabriel, Miguel; Ayté del Olmo, José; Leidel, Sebastian; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2013)
    The Elongator complex, including the histone acetyl transferase Sin3/Elp3, was isolated as an RNA polymerase II-interacting complex, and cells deficient in Elongator subunits display transcriptional defects. However, it ...
  • Carmona, Mercè; de Cubas, Laura; Bautista, Eric; Moral-Blanch, Marta; Medrano-Fernández, Iria; Sitia, Roberto; Boronat i Llop, Susanna, 1965-; Ayté del Olmo, José; Hidalgo Hernando, Elena (Nature Research, 2019)
    Genetically encoded probes monitoring H2O2 fluctuations in living organisms are key to decipher redox signaling events. Here we use a new probe, roGFP2-Tpx1.C169S, to monitor pre-toxic fluctuations of peroxides in fission ...
  • Montañés, José Carlos; Huertas, Marta; Moro, Simone G.; Blevins, William Robert, 1987-; Carmona, Mercè; Ayté del Olmo, José; Hidalgo Hernando, Elena; Albà Soler, Mar (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    The unicellular yeast Schizosaccharomyces pombe (fission yeast) retains many of the splicing features observed in humans and is thus an excellent model to study the basic mechanisms of splicing. Nearly half the genes contain ...
  • Montañés, José Carlos; Huertas, Marta; Moro, Simone G.; Blevins, William Robert, 1987-; Carmona, Mercè; Ayté del Olmo, José; Hidalgo Hernando, Elena; Albà Soler, Mar (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    The unicellular yeast Schizosaccharomyces pombe (fission yeast) retains many of the splicing features observed in humans and is thus an excellent model to study the basic mechanisms of splicing. Nearly half the genes contain ...
  • Sánchez Mir, Laura; Salat Canela, Clàudia; Paulo Mirasol, Esther, 1984-; Carmona, Mercè; Ayté del Olmo, José; Oliva Miguel, Baldomero; Hidalgo Hernando, Elena (Springer, 2017)
    Stress-dependent activation of signaling cascades is often mediated by phosphorylation events, but the exact nature and role of these phosphorelays are frequently poorly understood. Here, we review which are the consequences ...
  • Salat Canela, Clàudia, 1989-; Carmona, Mercè; Martín-García, Rebeca; Pérez, Pilar; Ayté del Olmo, José; Hidalgo Hernando, Elena (Elsevier, 2021)
    Cdc42 GTPase rules cell polarity and growth in fission yeast. It is negatively and positively regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), respectively. Active Cdc42-GTP ...
  • Boronat i Llop, Susanna, 1965-; Domènech, Alba; Paulo Mirasol, Esther, 1984-; Calvo, Isabel A.; García Santamarina, Sarela, 1978-; García, Patrícia; Encinar del Dedo, Javier; Barcons-Simon, Anna; Serrano, Erica; Carmona, Mercè; Hidalgo Hernando, Elena (Elsevier, 2014)
    Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the ...

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