Browsing by Author "Carhart-Harris, Robin L."

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  • A whole-brain model of the neural entropy increase elicited by psychedelic drugs
    Herzog, Rubén; Mediano, Pedro A. M.; Rosas, Fernando E.; Lodder, Paul; Carhart-Harris, Robin L.; Sanz Perl, Yonatan; Tagliazucchi, Enzo; Cofre, Rodrigo (Nature Research, 2023)
    Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the ...
  • Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
    Atasoy, Selen; Roseman, Leor; Kaelen, Mendel; Kringelbach, Morten L.; Deco, Gustavo; Carhart-Harris, Robin L. (Nature Research, 2017)
    Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ’connectome-harmonic decomposition’, a novel ...
  • Distributed harmonic patterns of structure-function dependence orchestrate human consciousness
    Luppi, Andrea I.; Vohryzek, Jakub; Kringelbach, Morten L.; Martinez Mediano, Pedro Antonio; Adapa, Ram; Carhart-Harris, Robin L.; Roseman, Leor; Pappas, Ioannis; Peattie, Alexander R. D.; Manktelow, Anne E.; Sahakian, Barbara J.; Finoia, Paola; Williams, Guy B.; Allanson, Judith; Pickard, John D.; Menon, David K.; Atasoy, Selen; Stamatakis, Emmanuel A. (Nature Research, 2023)
    A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations ...
  • Dynamic coupling of whole-brain neuronal and neurotransmitter systems
    Kringelbach, Morten L.; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Moos Knudsen, Gitte; Carhart-Harris, Robin L.; Whybrow, Peter C.; Logothetis, N.; Deco, Gustavo (National Academy of Sciences, 2020)
    Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich ...
  • Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
    Cruzat Grand, Josefina, 1983-; Sanz Perl, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; Roseman, Leor; Luppi, Andrea I.; Ibañez, Agustin; Nutt, David; Carhart-Harris, Robin L.; Tagliazucchi, Enzo; Deco, Gustavo; Kringelbach, Morten L. (MIT Press, 2022)
    Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently ...
  • Increased sensitivity to strong perturbations in a whole-brain model of LSD
    Jobst, Beatrice M.; Atasoy, Selen; Ponce-Alvarez, Adrián; Sanjuán, Ana; Roseman, Leor; Kaelen, Mendel; Carhart-Harris, Robin L.; Kringelbach, Morten L.; Deco, Gustavo (Elsevier, 2021)
    Lysergic acid diethylamide (LSD) is a potent psychedelic drug, which has seen a revival in clinical and pharmacological research within recent years. Human neuroimaging studies have shown fundamental changes in brain-wide ...
  • LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics
    Ruffini, Giulio; Damiani, Giada; Lozano-Soldevilla, Diego; Deco, Nikolas; Rosas, Fernando E.; Kiani, Narsis A.; Ponce-Alvarez, Adrián; Kringelbach, Morten L.; Carhart-Harris, Robin L.; Deco, Gustavo (Public Library of Science (PLoS), 2023)
    A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organization of the brain. In particular, the notion that the brain operates near ...
  • Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape
    Singleton, S. Parker; Luppi, Andrea I.; Carhart-Harris, Robin L.; Cruzat Grand, Josefina, 1983-; Roseman, Leor; Nutt, David J.; Deco, Gustavo; Kringelbach, Morten L.; Stamatakis, Emmanuel A.; Kuceyeski, Amy (Nature Research, 2022)
    Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. Serotonin 2a (5-HT2a) receptor agonism by these compounds is associated ...
  • Whole-brain multimodal neuroimaging model using serotonin receptor maps explains non-linear functional effects of LSD
    Deco, Gustavo; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Knudsen, Gitte M.; Carhart-Harris, Robin L.; Whybrow, Peter C.; Logothetis, Nikos K.; Kringelbach, Morten L. (Elsevier, 2018)
    Understanding the underlying mechanisms of the human brain in health and disease will require models with necessary and sufficient details to explain how function emerges from the underlying anatomy and is shaped by ...