Browsing by Author "Cantero Recasens, Gerard, 1984-"

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  • ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1
    Blume, Julia von; Alleaume, Anne-Marie; Cantero Recasens, Gerard, 1984-; Curwin, Amy; Carreras Sureda, Amado, 1986-; Zimmermann, Timo; Galen, Josse van; Wakana, Yuichi; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Elsevier, 2011)
    Actin-severing proteins ADF/cofilin are required for the sorting of secretory cargo at the trans-Golgi network (TGN) in mammalian cells. How do these cytoplasmic proteins interact with the cargoes in the lumen of the TGN? ...
  • Cellular Ca2+ homeostasis in the pathophysiology of chronic respiratory diseases
    Cantero Recasens, Gerard, 1984- (Universitat Pompeu Fabra, 2013-01-10)
    Calcium works as a second intracellular messenger in all cell types and its downstream signalling is a key pathway for many systemic functions. In the lungs, the majority of activating stimuli trigger intracellular calcium ...
  • Discovery of putative prognostic and therapeutic miRNA in uEVs of Dent's Disease 1 patients and characterisation of cellular models of the disease
    Burballa Tàrrega, Carla, 1988- (2021-05-14)
    Dent disease 1 (DD1) is a rare renal tubulopathy caused by CLCN5 mutations and characterized by low molecular weight proteinuria, variable hypercalciuria, nephrocalcinosis and/or nephrolithiasis and progression to kidney ...
  • KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon
    Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Valverde, M. A. (Miguel Ángel), 1963-; Naranjo, José R.; Brouwers, Nathalie; Malhotra, Vivek (eLife, 2018)
    Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline ...
  • Novel Dent disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function
    Durán, Mónica; Burballa Tàrrega, Carla, 1988-; Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Malhotra, Vivek; Ariceta, Gema; Sarró, Eduard; Meseguer, Anna (Oxford University Press, 2021)
    Dent disease 1 (DD1) is a rare X-linked renal proximal tubulopathy characterized by low molecular weight proteinuria and variable degree of hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressing to chronic ...
  • Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
    Cantero Recasens, Gerard, 1984-; Alonso-Marañón, Josune; Lobo-Jarne, Teresa; Garrido, Marta; Iglesias Coma, Mar; Espinosa Blay, Lluís; Malhotra, Vivek (eLife, 2022)
    Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier ...
  • Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
    Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Brouwers, Nathalie; Mitrovic, Sandra; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (American Society for Biochemistry and Molecular Biology (ASBMB), 2019)
    Regulated mucin secretion is essential for the formation of the mucus layer that protects the underlying epithelial cells from foreign particles. Alterations in the quantity or quality of secreted mucins are therefore ...
  • TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells
    Mitrovic, Sandra; Nogueira, Cristina; Cantero Recasens, Gerard, 1984-; Kiefer, Kerstin, 1986-; Fernández-Fernández, José Manuel, 1967-; Popoff, Jean-François; Casano, Laetitia; Bard, Frederic A.; Gómez, Raul; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (eLife, 2013)
    Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic ...