Browsing by Author "Campelo, Felix"

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  • Raote, Ishier; Chabanon, Morgan; Walani, Nikhil; Arroyo, Marino; Garcia-Parajo, Maria F.; Malhotra, Vivek; Campelo, Felix (eLife, 2020)
    The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) ...
  • Bassaganyas Bars, Laia, 1985-; Popa, Stephanie J.; Horlbeck, Max; Puri, Claudia; Stewart, Sarah E.; Campelo, Felix; Ashok, Anupama, 1985-; Butnaru, Cristian M.; Brouwers, Nathalie; Heydari, Kartoosh; Ripoche, Jean; Weissman, Jonathan; Rubinsztein, David C.; Schekman, Randy; Malhotra, Vivek; Moreau, Kevin; Villeneuve, Julien (Rockefeller University Press, 2019)
    Protein and membrane trafficking pathways are critical for cell and tissue homeostasis. Traditional genetic and biochemical approaches have shed light on basic principles underlying these processes. However, the list of ...
  • Bottanelli, Francesca; Cadot, Bruno; Campelo, Felix; Curran, Scott; Davidson, Patricia M.; Dey, Gautam; Raote, Ishier; Straube, Anne; Swaffer, Matthew P. (Company of Biologists, 2020)
    The COVID-19 pandemic has disrupted traditional modes of scientific communication. In-person conferences and seminars have been cancelled and most scientists around the world have been confined to their homes. Although ...
  • Campelo, Felix; van Galen, Josse; Turacchio, Gabriele; Parashuraman, Seetharaman; Kozlov, Michael M.; García Parajó, María F.; Malhotra, Vivek (eLife, 2017)
    The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us ...
  • Muñoz-Gil, Gorka; Romero-Aristizabal, Catalina; Mateos, Nicolas; Campelo, Felix; De Llobet, Lara Isabel; Beato, Miguel; Lewenstein, Maciej; Garcia-Parajo, Maria F.; Torreno-Pina, Juan A. (National Academy of Sciences, 2022)
    Liquid-liquid phase separation (LLPS) is emerging as a key physical principle for biological organization inside living cells, forming condensates that play important regulatory roles. Inside living nuclei, transcription ...
  • Raote, Ishier; Ortega Bellido, María; Santos, António J. M.; Foresti, Ombretta; Zhang, Chong; García Parajó, María F.; Campelo, Felix; Malhotra, Vivek (eLife, 2018)
    Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky ...
  • Raote, Ishier; Saxena, Sonashree; Campelo, Felix; Malhotra, Vivek (Elsevier, 2021)
    TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of the ER membrane to create a distinct domain. ...
  • Raote, Ishier; Ernst, Andreas M.; Campelo, Felix; Rothman, James E.; Pincet, Frederic; Malhotra, Vivek (eLife, 2020)
    We have previously shown TANGO1 organises membranes at the interface of the endoplasmic reticulum (ER) and ERGIC/Golgi (Raote et al., 2018). TANGO1 corrals retrograde membranes at ER exit sites to create an export conduit. ...