Visualitza per autoria "Calvo, Isabel A."

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  • A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase
    Paulo Mirasol, Esther, 1984-; García Santamarina, Sarela, 1978-; Calvo, Isabel A.; Carmona, Mercè; Boronat i Llop, Susanna, 1965-; Domènech, Alba; Ayté del Olmo, José; Hidalgo Hernando, Elena (Wiley-Blackwell, 2014)
    The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion ...
  • Dissection of a redox relay: H2O2-dependent activation of the transcription factor pap1 through the peroxidatic tpx1-thioredoxin cycle
    Calvo, Isabel A.; Boronat i Llop, Susanna, 1965-; Domènech, Alba; García Santamarina, Sarela, 1978-; Ayté del Olmo, José; Hidalgo Hernando, Elena (Elsevier, 2013)
    In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program. However, the mechanisms that regulate the sensitivity ...
  • Genome-wide screen of genes required for caffeine tolerance in fission yeast
    Calvo, Isabel A.; Gabrielli, Natalia, 1978-; Iglesias Baena, Iván; García Santamarina, Sarela, 1978-; Hoe, Kwang-Lae; Kim, Dong Uk; Sansó Martínez, Miriam, 1979-; Zuin, Alice, 1978-; Pérez, Pilar; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2009)
    Background: An excess of caffeine is cytotoxic to all eukaryotic cell types. We aim to study how cells become tolerant to a/ntoxic dose of this drug, and the relationship between caffeine and oxidative stress pathways./n ...
  • Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach
    García Santamarina, Sarela, 1978-; Boronat i Llop, Susanna, 1965-; Calvo, Isabel A.; Rodríguez Gabriel, Miguel; Ayté del Olmo, José; Molina, Henrik; Hidalgo Hernando, Elena (Mary Ann Liebert, Inc, 2013)
    Cysteine oxidation mediates oxidative stress toxicity and signaling. It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling ...
  • Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast
    Zuin, Alice, 1978-; Gabrielli, Natalia, 1978-; Calvo, Isabel A.; García Santamarina, Sarela, 1978-; Hoe, Kwang-Lae; Kim, Dong Uk; Park, Han-Oh; Hayles, Jacqueline; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2008)
    Background: Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. Methodology/Principal Findings: We analyzed ...
  • Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1
    Calvo, Isabel A.; Ayté del Olmo, José; Hidalgo Hernando, Elena (Company of Biologists, 2013)
    Reversible thiol oxidation is both a mark of hydrogen peroxide (H2O2) toxicity and an initiator of signalling events. H2O2 sensors contain exposed and reactive cysteine residues, which become transiently oxidized as an ...
  • The peroxiredoxin Tpx1 is essential as a H202-scavenger during aerobic growth in fission yeast
    Jara, Mónica; Vivancos Prellezo, Ana; Calvo, Isabel A.; Moldón Vara, Alberto; Sansó Martínez, Miriam, 1979-; Hidalgo Hernando, Elena (American Society for Cell Biology, 2007)
    Peroxiredoxins are known to interact with hydrogen peroxide (H2O2) and to participate in oxidant scavenging, redox signal transduction, and heat-shock responses. The two-cysteine peroxiredoxin Tpx1 of Schizosaccharomyces ...
  • Thiol-based H2O2 signalling in microbial systems
    Boronat i Llop, Susanna, 1965-; Domènech, Alba; Paulo Mirasol, Esther, 1984-; Calvo, Isabel A.; García Santamarina, Sarela, 1978-; García, Patrícia; Encinar del Dedo, Javier; Barcons-Simon, Anna; Serrano, Erica; Carmona, Mercè; Hidalgo Hernando, Elena (Elsevier, 2014)
    Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the ...
  • The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2
    Calvo, Isabel A.; García, Patrícia; Ayté del Olmo, José; Hidalgo Hernando, Elena (Oxford University Press, 2012)
    In response to hydrogen peroxide (H2O2), the transcription factor Pap1 from Schizosaccharomyces pombe regulates transcription of genes required for adaptation to oxidative stress and for tolerance to toxic drugs. H2O2 ...

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