Browsing by Author "Calon, Alexandre"

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  • Chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis exhibits an increased inflammatory signature that is reduced in early-stage chronic lymphocytic leukemia
    Blanco Ares, Gonzalo, 1989-; Puiggros Metje, Anna Maria; Sherry, Barbara; Nonell Mazelón, Lara; Calvo Gonzalo, Xavier; Puigdecanet Riubugent, Eulàlia; Arnal, Magdalena; Rodríguez-Rivera, María; Gimeno Vázquez, Eva; Abella Monreal, Eugenia; Calon, Alexandre; Ferrer Del Alamo, Ana; Espinet Solà, Blanca (Elsevier, 2021)
    Several studies in chronic lymphocytic leukemia (CLL) patients have reported impaired immune cell functions, which contribute to tumor evasion and disease progression. However, studies on CLL-like monoclonal B-cell ...
  • Detection of postoperative plasma circulating tumour DNA and lack of CDX2 expression as markers of recurrence in patients with localised colon cancer
    Tarazona, Noelia; Calon, Alexandre; Cervantes, Andrés (Elsevier, 2020)
    Background: Colon cancer (CC) is a heterogeneous disease. Novel prognostic factors beyond pathological staging are required to accurately identify patients at higher risk of relapse. Integrating these new biological factors, ...
  • Determinants and functions of CAFs secretome during cancer progression and therapy
    Linares Aceituno, Jenniffer Lissethe; Marín Jiménez, Juan A.; Badia-Ramentol, Jordi; Calon, Alexandre (Frontiers, 2021)
    Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor ...
  • Determinants of metastatic competency in colorectal cancer
    Tauriello, Daniele V.F.; Calon, Alexandre; Lonardo, Enza; Batlle Gómez, Eduard (Wiley, 2017)
    Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early-stage ...
  • Minimal residual disease, metastasis and immunity
    Badia-Ramentol, Jordi; Linares Aceituno, Jenniffer Lissethe; Gómez-Llonín, Andrea; Calon, Alexandre (MDPI, 2021)
    Progression from localized to metastatic disease requires cancer cells spreading to distant organs through the bloodstream. Only a small proportion of these circulating tumor cells (CTCs) survives dissemination due to ...
  • Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
    Calon, Alexandre; Lonardo, Enza; Berenguer-Llergo, Antonio; Espinet, Elisa; Hernando-Momblona, Xavier; Iglesias Coma, Mar; Sevillano, Marta; Palomo-Ponce, Sergio; Tauriello, Daniele V.F.; Byrom, Daniel; Cortina Duran, Carme; Morral, Clara; Barceló, Carles; Tosi, Sebastien; Riera, Antoni; Attolini, Camille Stephan-Otto; Rossell, David; Sancho, Elena; Batlle Gómez, Eduard (Nature Publishing Group, 2015)
    Recent molecular classifications of colorectal cancer (CRC) based on global gene expression profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon evaluation of these classification systems, ...
  • Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors
    Rivas, Elisa; Linares Aceituno, Jenniffer Lissethe; Zwick, Melissa; Gómez-Llonín, Andrea; Guiu, Marc; Labernadie, Anna; Badia-Ramentol, Jordi; Lladó, Anna; Bardia, Lídia; Pérez-Núñez, Iván; Martínez-Ciarpaglini, Carolina; Tarazona, Noelia; Sallent-Aragay, Anna; Garrido, Marta; Celià-Terrassa, Toni; Burgués, Octavio; Gomis, Roger R.; Albanell Mestres, Joan; Calon, Alexandre (Nature Research, 2022)
    About 50% of human epidermal growth factor receptor 2 (HER2)+ breast cancer patients do not benefit from HER2-targeted therapy and almost 20% of them relapse after treatment. Here, we conduct a detailed analysis of two ...