Browsing by Author "Calle, M. Luz"

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  • Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk
    López De Maturana, Evangelina; Ye, Yuanqing; Calle, M. Luz; Rothman, Nathaniel; Urrea, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen J.; Tardón, Adonina; García Closas, Montserrat; González Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Lorente-Galdós, Belén, 1981-; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science (PLoS), 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • Efficient and powerful method for combining p-values in Genome-wide Association Studies
    Vilor Tejedor, Natàlia, 1988-; González Ruiz, Juan Ramón; Calle, M. Luz (Institute of Electrical and Electronics Engineers (IEEE), 2016)
    The goal of Genome-wide Association Studies (GWAS) is the identification of genetic variants, usually Single Nucleotide Polymorphisms (SNPs), that are associated with disease risk. However, SNPs detected so far with GWAS ...
  • Genetic variation in the TP53 pathway and bladder cancer risk: a comprehensive analysis
    Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta Trull, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Global adaptive rank truncated product method for gene-set analysis in association studies
    Vilor Tejedor, Natàlia, 1988-; Calle, M. Luz (Wiley-VCH Verlag, 2014)
    Gene set analysis (GSA) aims to assess the overall association of a set of genetic variants with a phenotype and has the potential to detect subtle effects of variants in a gene or a pathway that might be missed when ...
  • Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features
    Font, Albert; Doménech, Montserrat; Ramirez, Jose Luis; Marqués, Miriam; Benítez, Raquel; Ruiz de Porras, Vicenç; Gago, José L.; Carrato, Cristina; Sant, Francesc; López, Héctor; Castellano, Daniel; Malats i Riera, Núria; Calle, M. Luz; Real, Francisco X. (Frontiers, 2023)
    Background and objective: Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no ...
  • Risk prediction scores for recurrence and progression of non-muscle invasive bladder cancer: an international validation in primary tumours
    Vedder, Moniek M.; Márquez, Mirari; De Bekker-Grob; Calle, M. Luz; Dyrskjøt, Lars; Kogevinas, Manolis; Segersten, Ulrika; Malmström, Per-Uno; Algaba, Ferran; Beukers, Willemien; Orntoft, Torben F.; Zwarthoff, Ellen; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Objective: We aimed to determine the validity of two risk scores for patients with non-muscle invasive bladder cancer in different European settings, in patients with primary tumours. Methods: We included 1,892 patients ...