Browsing by Author "Cacciaglia, Raffaele"

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  • Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
    Cacciaglia, Raffaele; Salvadó, Gemma; Molinuevo, José Luis; Shekari, Mahnaz; Falcón, Carles; Operto, Grégory; Suárez-Calvet, Marc; Milà Alomà, Marta; Sala, Arianna; Rodriguez-Vieitez, Elena; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Nature Research, 2022)
    Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer's continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these ...
  • APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
    Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Shekari, Mahnaz; Milà Alomà, Marta; Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Falcón, Carles; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Springer, 2023)
    Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU ...
  • APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Esteller, Manel; Morán, Sebastián; Fauria, Karine; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2019)
    The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. ...
  • APOE-ε4 shapes the cerebral organization in cognitively intact individuals as reflected by structural gray matter networks
    Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2020)
    Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor ...
  • Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
    Grau-Rivera, Oriol; Operto, Grégory; Falcón, Carles; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Brugulat Serrat, Anna, 1986-; Gramunt Fombuena, Nina; Salvadó, Gemma; Suárez-Calvet, Marc; Minguillón, Carolina; Iranzo, Alex; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (BioMed Central, 2020)
    Background: Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize ...
  • Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex
    Cumplido-Mayoral, Irene; Operto, Grégory; Falcón, Carles; Shekari, Mahnaz; Cacciaglia, Raffaele; Milà Alomà, Marta; Minguillón, Carolina; Suárez-Calvet, Marc; Gispert López, Juan Domingo; OASIS study (eLife, 2023)
    Brain-age can be inferred from structural neuroimaging and compared to chronological age (brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer's ...
  • DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
    Sala Vila, Aleix; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Grau-Rivera, Oriol; González de Echávarri, José Maria; Crous-Bou, Marta; Minguillón, Carolina; Fauria, Karine; Operto, Grégory; Falcón, Carles; Salvadó, Gemma; Cacciaglia, Raffaele; Ingala, Silvia; Barkhof, Frederik; Schröder, Helmut, 1958-; Scarmeas, Nikolaos; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (American Society for Nutrition, 2021)
    Background: The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (22:6n-3) before the onset of AD symptoms, ...
  • Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD
    Stankeviciute, Laura; Falcón, Carles; Operto, Grégory; Garcia, Marina; Shekari, Mahnaz; Iranzo, Alex; Niñerola-Baizán, Aida; Perissinotti, Andrés; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Cacciaglia, Raffaele; Gispert López, Juan Domingo; Grau-Rivera, Oriol; ALFA Study (Wiley, 2023)
    Introduction: Poor sleep quality is associated with cognitive outcomes in Alzheimer's disease (AD). We analyzed the associations between self-reported sleep quality and brain structure and function in cognitively unimpaired ...
  • Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
    Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Evans, Tavia E.; Falcón, Carles; Crous-Bou, Marta; Minguillón, Carolina; Cacciaglia, Raffaele; Milà Alomà, Marta; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Garrido Martín, Diego, 1992-; Morán, Sebastián; Esteller, Manel; Adams, Hieab H.; Molinuevo, José Luis; Guigó Serra, Roderic; Gispert López, Juan Domingo; ALFA Study (Springer, 2020)
    Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association ...
  • Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
    Cacciaglia, Raffaele; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; Falcón, Carles; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Grau-Rivera, Oriol; Gispert López, Juan Domingo; ALFA Study (Wiley, 2018)
    The neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies reported that larger brain ...
  • Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
    Cacciaglia, Raffaele; Operto, Grégory; Falcón, Carles; González de Echávarri, José Maria; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Milà Alomà, Marta; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2022)
    The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations in preclinical stages of the ...
  • NeAT: a nonlinear analysis toolbox for neuroimaging
    Casamitjana, Adrià; Vilaplana, Verónica; Puch, Santi; Aduriz, Asier; López, Carlos; Operto, Grégory; Cacciaglia, Raffaele; Falcón, Carles; Molinuevo, José Luis; Domingo Gispert, Juan; Alzheimer’s Disease Neuroimaging Initiative (SpringerOpen, 2021)
    NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. ...
  • Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals
    Martí Juan, Gerard; Sanromà, Gerard; Cacciaglia, Raffaele; Falcón, Carles; Operto, Grégory; Molinuevo, José Luis; González Ballester, Miguel Ángel, 1973-; Domingo Gispert, Juan; Piella Fenoy, Gemma; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Wiley, 2020)
    The ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including ...
  • Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI
    Petrone, Paula M.; Casamitjana, Adrià; Falcón, Carles; Artigues, Miquel; Operto, Grégory; Cacciaglia, Raffaele; Molinuevo, José Luis; Vilaplana, Verónica; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)
    Background: Magnetic resonance imaging (MRI) has unveiled specific alterations at different stages of Alzheimer's disease (AD) pathophysiologic continuum constituting what has been established as "AD signature". To what ...
  • Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Operto, Grégory; Falcón, Carles; Cacciaglia, Raffaele; Minguillón, Carolina; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (SpringerOpen, 2022)
    Purpose: glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid ...
  • Sleep in the preclinical stages of Alzheimer's disease: a multimodal biomarkers approach
    Stankeviciute, Laura (Universitat Pompeu Fabra, 2023-12-19)
    This Thesis delves into the intricate relationship between sleep disruptions and Alzheimer's disease (AD). Sleep disturbances are a prevalent feature of AD, and evidence suggests they may accelerate cognitive decline. ...
  • Soundtrack of life: an fMRI study
    Falcon, Carles; Navarro-Plaza, Mari Carmen; Gramunt Fombuena, Nina; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Cacciaglia, Raffaele; González de Echávarri, José Maria; Sanchez-Benavides, Gonzalo; Operto, Grégory; Knezevic, Iva; Molinuevo, José Luis; Domingo Gispert, Juan (Elsevier, 2022)
    Most people have a soundtrack of life, a set of special musical pieces closely linked to certain biographical experiences. Autobiographical memories (AM) and music listening (ML) involve complex mental processes ruled by ...
  • The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study
    Cumplido-Mayoral, Irene; Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; González Escalante, Armand; Anastasi, Federica; Milà Alomà, Marta; López Martos, David; Akinci, Muge; Falcón, Carles; Shekari, Mahnaz; Cacciaglia, Raffaele; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Vilaplana, Verónica; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2024)
    Background: Neuroimaging-based brain-age delta has been shown to be a mediator linking cardiovascular risk factors to cognitive function. We aimed to assess the mediating role of brain-age delta in the association between ...
  • The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
    Salvadó, Gemma; Operto, Grégory; Cumplido-Mayoral, Irene; Arenaza Urquijo, Eider M.; Cacciaglia, Raffaele; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Minguillón, Carolina; Gispert López, Juan Domingo; ADNI (Wiley, 2022)
    Introduction: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired ...
  • White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
    Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)
    White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...

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