Browsing by Author "Cañas, Xavier"

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  • Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.
    Manils, Joan; Gómez, Diana; Salla-Martret, Mercè; Fischer, Heinz; Fye, Jason M.; Marzo, Elena; Marruecos, Laura; Serrano, Inma; Salgado, Rocío; Rodrigo, Juan P.; Garcia-Pedrero, Juana M.; Serafin, Anna M.; Cañas, Xavier; Benito, María del Carmen; Toll Abelló, Agustín; Forcales Fernàndez, Sonia-Vanina; Perrino, Fred W.; Eckhart, Leopold; Soler Prat, Concepció (Impact Journals, 2015)
    TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic ...
  • Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression
    Marruecos, Laura; Manils, Joan; Moreta, Cristina; Gómez, Diana; Filgaira, Ingrid; Serafín, Anna; Cañas, Xavier; Espinosa Blay, Lluís; Soler Prat, Concepció (Nature Research, 2021)
    Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we ...

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