Browsing by Author "Cáceres, Javier F."

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  • DGCR8 HITS-CLIP reveals novel functions for the Microprocessor
    Macias, Sara; Plass Pórtulas, Mireya, 1982-; Stajuda, Agata; Michlewski, Gracjan; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Nature Research, 2012)
    The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking ...
  • Drosha regulates gene expression independently of RNA cleavage function
    Gromak, Natalia; Dienstbier, Martin; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Eyras Jiménez, Eduardo; Cáceres, Javier F.; Proudfoot, Nicholas J. (Elsevier, 2013)
    Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically ...
  • The Microprocessor controls the activity of mammalian retrotransposons
    Heras, Sara R.; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Fernandez, Noemí; Cano Ferrer, David; Eyras Jiménez, Eduardo; Garcia Perez, José L.; Cáceres, Javier F. (Nature Research, 2013)
    More than half of the human genome is made of transposable elements whose ongoing mobilization is a driving force in genetic diversity; however, little is known about how the host regulates their activity. Here, we show ...
  • The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development
    Rodor, Julie; FitzPatrick, David R.; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Taylor & Francis (Routledge), 2017)
    Mutations in the RNA-binding protein, RBM10, result in a human syndromic form of cleft palate, termed TARP syndrome. A role for RBM10 in alternative splicing regulation has been previously demonstrated in human cell lines. ...
  • The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation
    Rodor, Julie; Pan, Qun; Blencowe, Benjamin J.; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Cold Spring Harbor Laboratory Press (CSHL Press), 2016)
    Acinus (apoptotic chromatin condensation inducer in the nucleus) is an RNA-binding protein (RBP) originally identified for its role in apoptosis. It was later found to be an auxiliary component of the exon junction complex ...
  • The translational landscape of the splicing factor SRSF1 and its role in mitosis
    Maslon, Magdalena M.; Heras, Sara R.; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo; Cáceres, Javier F. (eLife, 2014)
    The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally ...