Burgess, Selena G.; Oleksy, Arkadiusz; Cavazza, Tommaso, 1985-; Richards, Mark W.; Vernos, Isabelle, 1959-; Matthews, David; Bayliss, Richard
(Royal Society, 2016)
The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric ...