Browsing by Author "Borràs, Eva"

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  • A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
    Roewenstrunk, Julia Maria, 1981-; Di Vona, Chiara, 1981-; Chen, Jie; Borràs, Eva; Dong, Chao; Arató, Krisztina, 1981-; Sabidó Aguadé, Eduard, 1981-; Huen, Michael S. Y.; Luna Gargantilla, Susana de la (Nature Research, 2019)
    Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, ...
  • A proteomic approach for systematic mapping of substrates of human deubiquitinating enzymes
    Ramirez, Juanma; Prieto, Gorka; Olazabal-Herrero, Anne; Borràs, Eva; Fernandez-Vigo, Elvira; Alduntzin, Unai; Osinalde, Nerea; Beaskoetxea, Javier; Lectez, Benoit; Aloria, Kerman; Rodríguez, José Antonio; Paradela, Alberto; Sabidó Aguadé, Eduard, 1981-; Muñoz, Javier; Corrales, Fernando; Arizmendi, Jesús M.; Mayor, Ugo (MDPI, 2021)
    The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly ...
  • Association of fish consumption and mercury exposure during pregnancy with metabolic health and inflammatory biomarkers in children
    Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)
    IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
  • Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort
    Robinson, Oliver; Lau, Chung-Ho E.; Joo, Sungyeon; Andrušaitytė, Sandra; Borràs, Eva; Prado Bert, Paula de; Chatzi, Lida Vaia; Keun, Hector C.; Gražulevičienė, Regina; Gutzkow, Kristine B.; Maitre, Léa; Martens, Dries S.; Sabidó Aguadé, Eduard, 1981-; Siroux, Valérie; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Bustamante Pineda, Mariona; Vrijheid, Martine (eLife, 2023)
    Background: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development ...
  • BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling
    Bradbury Lobato, Melissa, 1983-; Borràs, Eva; Castellví, Josep; Méndez, Olga; Sánchez-Iglesias, José Luis; Pérez-Benavente, Assumpció; Gil-Moreno, Antonio; Sabidó Aguadé, Eduard, 1981-; Santamaria, Anna (Nature Research, 2022)
    Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the ...
  • Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation
    Aranda Aragón, Sergio; Alcaine Colet, Anna, 1992-; Blanco, Enrique; Borràs, Eva; Caillot, Claire; Sabidó Aguadé, Eduard, 1981-; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2019)
    Profiling the chromatin-bound proteome (chromatome) in a simple, direct, and reliable manner might be key to uncovering the role of yet uncharacterized chromatin factors in physiology and disease. Here, we have designed ...
  • Chromatin-bound proteome profiling by genome capture
    Aranda Aragón, Sergio; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Di Croce, Luciano (Elsevier, 2020)
    De novo identification of chromatin interactors can reveal unexpected pathways relevant to physiology and human disease. Inspired by the DNA mediated chromatin pull-down (Dm-ChP) technology (also known as iPOND [isolation ...
  • DIA+: a data-independent acquisition method combining multiple precursor charges to improve peptide signal
    Borràs, Eva; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2018)
    Data-independent acquisition methods that acquire fragment ions from virtually any peptide in a sample have expanded the benefits of low-throughput targeted proteomics to proteome-wide analyses. While these methods have ...
  • Evaluation of different peptide fragmentation types and mass analyzers in data-dependent methods using an Orbitrap Fusion Lumos Tribrid mass spectrometer
    Espadas, Guadalupe; Borràs, Eva; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981- (Wiley, 2017)
    One of the major additions in MS technology has been the irruption of the Orbitrap mass analyzer, which has boosted the proteomics analyses of biological complex samples since its introduction. Here, we took advantage of ...
  • Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
    Maitre, Léa; De Bont, Jeroen, 1989-; Casas Sanahuja, Maribel; Robinson, Oliver; Basagaña Flores, Xavier; Borràs, Eva; Bustamante Pineda, Mariona; de Castro, Montserrat; Donaire González, David; Estivill, Xavier, 1955-; Fossati, Serena; González, Juan Ramón; Hernández-Ferrer, Carles; Júlvez Calvo, Jordi; Manzano Salgado, Cyntia Beatriz, 1987-; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; van Gent, Diana; Vives Usano, Marta, 1990-; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Vrijheid, Martine (BMJ Publishing Group, 2018)
    PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and ...
  • IKKα kinase regulates the DNA damage response and drives chemo-resistance in cancer
    Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; Villanueva, Alberto; Vert, Anna; Pecharroman, Irene; Solé, Laura; González-Farré, Mónica; Alonso, Josune; Montagut Viladot, Clara; Martínez Iniesta, María; Bertran, Joan; Borràs, Eva; Iglesias, Mar; Sabidó Aguadé, Eduard, 1981-; Bigas Salvans, Anna; Boulton, Simon J.; Espinosa Blay, Lluís (Elsevier, 2019)
    Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-¿B signaling. Insights into the sources ...
  • In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
    Vives Usano, Marta, 1990-; Hernández-Ferrer, Carles; Maitre, Léa; Ruiz Arenas, Carlos, 1990-; Borràs, Eva; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; González, Juan Ramón; Sabidó Aguadé, Eduard, 1981-; Vrijheid, Martine; Bustamante Pineda, Mariona (BioMed Central, 2020)
    Background: The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only ...
  • Mass spectrometry identification of biomarkers in extracellular vesicles from plasmodium vivax liver hypnozoite infections
    Gualdrón-López, Melisa; Díaz Varela, Míriam; Aparici-Herraiz, Iris; Cuscó Pons, Pol, 1987-; González, Juan Ramón; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Fernandez-Becerra, Carmen; del Portillo, Hernando A. (Elsevier, 2022)
    Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection and represent a major obstacle in the goal of malaria elimination. Hypnozoites are clinically undetectable, and presently, there are ...
  • Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
    Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
    Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Multi-omics signatures of the human early life exposome
    Maitre, Léa; Bustamante Pineda, Mariona; Hernández Ferrer, Carles; Vives Usano, Marta, 1990-; Ruiz-Arenas, Carlos; Pelegrí-Sisó, Dolors; Casas Sanahuja, Maribel; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; González, Juan Ramón; Vrijheid, Martine (Nature Research, 2022)
    Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) ...
  • Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
    Toda, Haruka; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; del Portillo, Hernando A. (Nature Research, 2020)
    Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular ...
  • Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts
    Papadopoulou, Eleni, 1985-; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Maitre, Léa; Sabidó Aguadé, Eduard, 1981-; Borràs, Eva; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (Elsevier, 2021)
    Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is ...
  • Proteomic studies on the management of high-grade serous ovarian cancer patients: a mini-review
    Bradbury Lobato, Melissa, 1983-; Borràs, Eva; Pérez-Benavente, Assumpció; Gil-Moreno, Antonio; Santamaria, Anna; Sabidó Aguadé, Eduard, 1981- (MDPI, 2021)
    High-grade serous ovarian cancer (HGSC) remains the most common and deadly subtype of ovarian cancer. It is characterized by its late diagnosis and frequent relapse despite standardized treatment with cytoreductive surgery ...
  • QCloud2: an improved cloud-based quality-control system for mass-spectrometry-based proteomics laboratories
    Olivella, Roger; Chiva, Cristina; Serret, Marc; Mancera, Daniel; Cozzuto, Luca; Hermoso Pulido, Antonio; Borràs, Eva; Espadas, Guadalupe; Morales Sanfrutos, Julia; Pastor, Olga; Solé, Amanda; Ponomarenko, Julia; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2021)
    QCloud is a cloud-based system to support proteomics laboratories in daily quality assessment using a user-friendly interface, easy setup, and automated data processing. Since its release, QCloud has facilitated automated ...

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