Browsing by Author "Bonet Martínez, Jaume, 1982-"

Sort by: Order: Results:

  • Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity
    Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Valls Comamala, Victòria, 1987-; Bosch Morató, Mònica, 1986-; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C.; Perálvarez Marín, Alex; Fernández-Busquets, Xavier; Andreu Martínez, David; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Society for Neuroscience, 2016)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal to β-sheet conformation, promoting its ...
  • ArchDB 2014: structural classification of loops in proteins
    Bonet Martínez, Jaume, 1982-; Planas Iglesias, Joan, 1980-; García-García, Javier, 1982-; Marín López, Manuel Alejandro, 1987-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2014)
    The function of a protein is determined by its three-dimensional structure, which is formed by regular (i.e. β-strands and α-helices) and non-periodic structural units such as loops. Compared to regular structural elements, ...
  • CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells
    Wright, Roni H.G.; Castellano, Giancarlo; Bonet Martínez, Jaume, 1982-; Le Dily, François; Font Mateu, Jofre, 1977-; Ballaré, Cecilia Julia; Nacht, A. Silvina; Soronellas, Daniel; Oliva Miguel, Baldomero; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Eukaryotic gene regulation implies that transcription factors gain access to genomic information via poorly understood processes involving activation and targeting of kinases, histone-modifying enzymes, and chromatin ...
  • Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.
    Sieberts, Solveig K.; García-García, Javier, 1982-; Aguilar, Daniel; Anton, Bernat; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Oliva Miguel, Baldomero; Mangravite, Lara M. (Nature Publishing Group, 2016)
    Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widelyused to reduce disease progression, treatment fails inBone-third of patients. No biomarkercurrently exists that identifies non-responders ...
  • Exploiting protein fragments in protein modelling and function prediction
    Bonet Martínez, Jaume, 1982- (Universitat Pompeu Fabra, 2015-01-30)
    Proteins are the basic functional and structural blocks of life. Knowledge of their structure and function is key to understand how it works. Lately, the gap between new discovered proteins and systematically studied ones ...
  • Human albumin impairs amyloid β-peptide fibrillation through its C-terminus: from docking modeling to protection against neurotoxicity in alzheimer's disease
    Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Inferring causal molecular networks: empirical assessment through a community-based effor
    Hill, Steven M.; Anton, Bernat; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Oliva Miguel, Baldomero; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Mukherjee, Sach; The HPN-DREAM Consortium (Nature Publishing Group, 2016)
    It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge, which ...
  • Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains
    Alvarez-Cienfuegos, Ana; Nuñez-Prado, Natalia; Compte, Marta; Cuesta, Angel M.; Blanco-Toribio, Ana; Harwood, Seandean Lykke; Villate, Maider; Merino, Nekane; Bonet Martínez, Jaume, 1982-; Navarro, Rocio; Muñoz-Briones, Clara; Sørensen, Karen Marie Juul; Mølgaard, Kasper; Oliva Miguel, Baldomero; Sanz, Laura; Blanco, Francisco; Alvarez-Vallina, Luis (Nature Publishing Group, 2016)
    Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to ...
  • On the mechanisms of protein interactions: Predicting their affinity from unbound tertiary structures
    Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Aguirre Plans, Joaquim, 1993-; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2018)
    MOTIVATION: The characterization of the protein-protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters ...
  • On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF
    Meseguer, Alberto; Årman, Filip; Fornés Crespo, Oriol, 1983-; Molina Fernández, Rubén; Bonet Martínez, Jaume, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2020)
    Cis2-His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans. To date, the DNA-binding preferences of many members of this family remain unknown. We have developed ...
  • On the use of direct-coupling analysis with a reduced alphabet of amino acids combined with super-secondary structure motifs for protein fold prediction
    Anton, Bernat; Besalú, Mireia; Fornés Crespo, Oriol, 1983-; Bonet Martínez, Jaume, 1982-; Molina, Alexis; Molina Fernández, Rubén; Cuevas, Gemma de las; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2021)
    Direct-coupling analysis (DCA) for studying the coevolution of residues in proteins has been widely used to predict the three-dimensional structure of a protein from its sequence. We present RADI/raDIMod, a variation of ...
  • SPServer: split-statistical potentials for the analysis of protein structures and protein-protein interactions
    Aguirre Plans, Joaquim, 1993-; Meseguer, Alberto; Molina Fernández, Rubén; Marín López, Manuel Alejandro, 1987-; Jumde, Gaurav; Casanova, Kevin; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein-protein interaction (PPI) ...
  • The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
    Valls Comamala, Victòria, 1987-; Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Puig, Marta; Perálvarez Marín, Alex; Palomer, Ernest; Fernàndez Busquets, Xavier; Altafaj, Xavier; Tajes Orduña, Marta; Puig Pijoan, Albert; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Impact Journals, 2017)
    The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both ...