Browsing by Author "Bonet Martínez, Jaume, 1982-"

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  • Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Valls Comamala, Victòria, 1987-; Bosch Morató, Mònica, 1986-; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C.; Perálvarez Marín, Alex; Fernández-Busquets, Xavier; Andreu Martínez, David; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Society for Neuroscience, 2016)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal to β-sheet conformation, promoting its ...
  • Bonet Martínez, Jaume, 1982-; Planas Iglesias, Joan, 1980-; García-García, Javier, 1982-; Marín López, Manuel Alejandro, 1987-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2014)
    The function of a protein is determined by its three-dimensional structure, which is formed by regular (i.e. β-strands and α-helices) and non-periodic structural units such as loops. Compared to regular structural elements, ...
  • Wright, Roni H.G.; Castellano, Giancarlo; Bonet Martínez, Jaume, 1982-; Le Dily, François; Font Mateu, Jofre, 1977-; Ballaré, Cecilia Julia; Nacht, A. Silvina; Soronellas, Daniel; Oliva Miguel, Baldomero; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Eukaryotic gene regulation implies that transcription factors gain access to genomic information via poorly understood processes involving activation and targeting of kinases, histone-modifying enzymes, and chromatin ...
  • Sieberts, Solveig K.; García-García, Javier, 1982-; Aguilar, Daniel; Anton, Bernat; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Oliva Miguel, Baldomero; Mangravite, Lara M. (Nature Publishing Group, 2016)
    Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widelyused to reduce disease progression, treatment fails inBone-third of patients. No biomarkercurrently exists that identifies non-responders ...
  • Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)
    Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
  • Hill, Steven M.; Anton, Bernat; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Oliva Miguel, Baldomero; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Mukherjee, Sach; The HPN-DREAM Consortium (Nature Publishing Group, 2016)
    It remains unclear whether causal, rather than merely correlational, relationships in molecular networks can be inferred in complex biological settings. Here we describe the HPN-DREAM network inference challenge, which ...
  • Alvarez-Cienfuegos, Ana; Nuñez-Prado, Natalia; Compte, Marta; Cuesta, Angel M.; Blanco-Toribio, Ana; Harwood, Seandean Lykke; Villate, Maider; Merino, Nekane; Bonet Martínez, Jaume, 1982-; Navarro, Rocio; Muñoz-Briones, Clara; Sørensen, Karen Marie Juul; Mølgaard, Kasper; Oliva Miguel, Baldomero; Sanz, Laura; Blanco, Francisco; Alvarez-Vallina, Luis (Nature Publishing Group, 2016)
    Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to ...
  • Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Aguirre Plans, Joaquim, 1993-; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2018)
    MOTIVATION: The characterization of the protein-protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters ...
  • Meseguer, Alberto; Årman, Filip; Fornés Crespo, Oriol, 1983-; Molina Fernández, Rubén; Bonet Martínez, Jaume, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2020)
    Cis2-His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans. To date, the DNA-binding preferences of many members of this family remain unknown. We have developed ...
  • Anton, Bernat; Besalú, Mireia; Fornés Crespo, Oriol, 1983-; Bonet Martínez, Jaume, 1982-; Molina, Alexis; Molina Fernández, Rubén; Cuevas, Gemma de las; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2021)
    Direct-coupling analysis (DCA) for studying the coevolution of residues in proteins has been widely used to predict the three-dimensional structure of a protein from its sequence. We present RADI/raDIMod, a variation of ...
  • Gohl, Patrick; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Planas Iglesias, Joan, 1980-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2023)
    Summary: The SBILib Python library provides an integrated platform for the analysis of macromolecular structures and interactions. It combines simple 3D file parsing and workup methods with more advanced analytical tools. ...
  • Aguirre Plans, Joaquim, 1993-; Meseguer, Alberto; Molina Fernández, Rubén; Marín López, Manuel Alejandro, 1987-; Jumde, Gaurav; Casanova, Kevin; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein-protein interaction (PPI) ...
  • Valls Comamala, Victòria, 1987-; Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Puig, Marta; Perálvarez Marín, Alex; Palomer, Ernest; Fernàndez Busquets, Xavier; Altafaj, Xavier; Tajes Orduña, Marta; Puig Pijoan, Albert; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Impact Journals, 2017)
    The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both ...

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