Browsing by Author "Bocharov, Gennady A."

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  • Tretyakova, Rufina M.; Meyerhans, Andreas; Bocharov, Gennady A. (De Gruyter, 2015)
    In our study we developed a computational algorithm for finding optimal dosages of antiretroviral drug administration for the stabilization of HIV load at low levels. The novelty is that the pharmacokinetics and pharmacodynamics ...
  • Banks, H. Thomas; Sutton, Karyn L.; Thompson, W. Clayton; Bocharov, Gennady A.; Doumic, Marie; Schenkel, Tim; Argilaguet Marqués, Jordi, 1977-; Giest, Sandra; Peligero Cruz, Cristina, 1986-; Meyerhans, Andreas (Elsevier, 2011)
    CFSE analysis of a proliferating cell population is a popular tool for the study of cell division and divisionlinked changes in cell behavior. Recently Banks et al. (2011), Luzyanina et al. (2009), Luzyanina et al. (2007), ...
  • Bocharov, Gennady A.; Volpert, Vitaly; Ludewig, Burkhard; Meyerhans, Andreas (Frontiers, 2020)
  • Banks, H. Thomas; Sutton, Karyn L.; Thompson, W. Clayton; Bocharov, Gennady A.; Roose, Dirk; Schenkel, Tim; Meyerhans, Andreas (Springer, 2011)
    Advances in fluorescent labeling of cells as measured by flow cytometry have allowed for quantitative studies of proliferating populations of cells. The investigations (Luzyanina et al. in J. Math. Biol. 54:57-89, 2007; ...
  • Martinez, Javier P.; Bocharov, Gennady A.; Ignatovich, Anna; Reiter, Jochen; Dittmar, Matthias T; Wain-Hobson, Simon; Meyerhans, Andreas (Public Library of Science (PLoS), 2011)
    Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness ...
  • Bouchnita, Anass; Bocharov, Gennady A.; Meyerhans, Andreas; Volpert, Vitaly (BioMed Central, 2017)
    BACKGROUND: Moving from the molecular and cellular level to a multi-scale systems understanding of immune responses requires the development of novel approaches to integrate knowledge and data from different biological ...
  • Grebennikov, Dmitry; Kholodareva, Ekaterina; Sazonov, Igor; Karsonova, Antonina; Meyerhans, Andreas; Bocharov, Gennady A. (MDPI, 2021)
    SARS-CoV-2 infection represents a global threat to human health. Various approaches were employed to reveal the pathogenetic mechanisms of COVID-19. Mathematical and computational modelling is a powerful tool to describe ...
  • Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina, 1991-; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Sazonov, Igor; Grebennikov, Dmitry; Meyerhans, Andreas; Bocharov, Gennady A. (MDPI, 2021)
    Replication of Human Immunodeficiency Virus type 1 (HIV) in infected CD4+ T cells represents a key driver of HIV infection. The HIV life cycle is characterised by the heterogeneity of infected cells with respect to ...
  • Bocharov, Gennady A.; Telatnikov, Ilya S.; Chereshnev, Valery A.; Martinez, Javier P.; Meyerhans, Andreas (De Gruyter, 2015)
    The aim of this work is the construction, calibration, and comparative analysis of mathematical models of the evolution of the human immunodeficiency virus (HIV) in the course of infection when the models are based on ...
  • Shcherbatova, Olga; Grebennikov, Dmitry; Sazonov, Igor; Meyerhans, Andreas; Bocharov, Gennady A. (MDPI, 2020)
    There are many studies that model the within-host population dynamics of Human Immunodeficiency Virus Type 1 (HIV-1) infection. However, the within-infected-cell replication of HIV-1 remains to be not comprehensively ...
  • Bessonov, Nickolay; Bocharov, Gennady A.; Meyerhans, Andreas; Popov, Vladimir; Volpert, Vitaly (MDPI, 2020)
    This work is devoted to the investigation of virus quasi-species evolution and diversification due to mutations, competition for host cells, and cross-reactive immune responses. The model consists of a nonlocal reaction–diffusion ...
  • Bocharov, Gennady A.; Casella, Valentina, 1991-; Argilaguet Marqués, Jordi, 1977-; Grebennikov, Dmitry; Güerri Fernández, Roberto; Ludewig, Burkhard; Meyerhans, Andreas (Frontiers, 2020)
  • Zheltkova, Valerya; Argilaguet Marqués, Jordi, 1977-; Peligero Cruz, Cristina, 1986-; Bocharov, Gennady A.; Meyerhans, Andreas (Public Library of Science (PLoS), 2019)
    The novel therapies with immune checkpoint inhibitors hold great promises for patients with chronic virus infections and cancers. This is based mainly on the partial reversal of the exhausted phenotype of antigen-specific ...
  • Grebennikov, Dmitry; Bouchnita, Anass; Volpert, Vitaly; Bessonov, Nickolay; Meyerhans, Andreas; Bocharov, Gennady A. (Frontiers, 2019)
    The surveillance of host body tissues by immune cells is central for mediating their defense function. In vivo imaging technologies have been used to quantitatively characterize target cell scanning and migration of ...
  • Bocharov, Gennady A.; Meyerhans, Andreas; Bessonov, Nickolay; Trofimchuk, Sergei; Volpert, Vitaly (Public Library of Science (PLoS), 2016)
    Virus spreading in tissues is determined by virus transport, virus multiplication in host cells and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate determined by the infection level. ...
  • Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina, 1991-; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
  • Bouchnita, Anass; Bocharov, Gennady A.; Meyerhans, Andreas; Volpert, Vitaly (MDPI, 2017)
    Human Immunodeficiency Virus (HIV) infection of humans represents a complex biological system and a great challenge to public health. Novel approaches for the analysis and prediction of the infection dynamics based on a ...
  • Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Hindawi, 2015)
    Virus infections represent complex biological systems governed by multiple-level regulatory processes of virus replication and host immune responses. Understanding of the infection means an ability to predict the systems ...