Browsing by Author "Blanco, Francisco"

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  • A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis
    Aterido Ballonga, Adrià, 1990-; Cañete Crespillo, Juan de Dios; Tornero, Jesús; Blanco, Francisco; Fernández-Gutiérrez, Benjamín; Pérez-García, Carolina; Alperiz, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González-Alvaro, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López Lasanta, María; López Corbeto, Mireia; Palau, Núria; Marsal, Sara; Julià, Antonio (Frontiers, 2019)
    Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients do not show ...
  • Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy
    Julià, Antonio; López-Lasanta, María; Blanco, Francisco; Gómez, Antonio; Haro, Isabel; Mas, Antonio Juan; Erra, Alba; García Vivar, María Luz; Monfort Faure, Jorge; Sánchez-Fernández, Simón; González, Isidoro; Alperi, Mercedes; Castellanos-Moreira, Raúl; Fernández-Nebro, Antonio; Díaz Torne, César; Palau, Núria; Lastra Borràs, Raquel; Lladós, Jordi; Sanmartí, Raimon; Marsal, Sara (BioMed Central, 2021)
    Background: blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50-60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TNF ...
  • Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains
    Alvarez-Cienfuegos, Ana; Nuñez-Prado, Natalia; Compte, Marta; Cuesta, Angel M.; Blanco-Toribio, Ana; Harwood, Seandean Lykke; Villate, Maider; Merino, Nekane; Bonet Martínez, Jaume, 1982-; Navarro, Rocio; Muñoz-Briones, Clara; Sørensen, Karen Marie Juul; Mølgaard, Kasper; Oliva Miguel, Baldomero; Sanz, Laura; Blanco, Francisco; Alvarez-Vallina, Luis (Nature Publishing Group, 2016)
    Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to ...
  • Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis
    Avila Pedretti, Gabriela; Tornero, Jesús; Fernández-Nebro, Antonio; Blanco, Francisco; González-Alvaro, Isidoro; Cañete Crespillo, Juan de Dios; Maymó Guarch, Joan; Alperiz, Mercedes; Fernández-Gutiérrez, Benjamín; Olivé, Alex; Corominas, Héctor; Erra, Alba; Aterido Ballonga, Adrià, 1990-; López Lasanta, María; Tortosa, Raül; Julià, Antonio; Marsal, Sara (Public Library of Science, 2015)
    OBJECTIVE: Anti-TNF therapies have been highly efficacious in the management of rheumatoid arthritis (RA), but 25-30% of patients do not show a significant clinical response. There is increasing evidence that genetic ...
  • XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation
    Mortuza, Gulnahar; Cavazza, Tommaso, 1985-; García Mayoral, María Flor; Hermida, Dario; Peset, Isabel; Pedrero, Juan G.; Merino, Nekane; Blanco, Francisco; Lyngsø, Jeppe; Bruix, Marta; Pedersen, Jan Skov; Vernos, Isabelle, 1959-; Montoya, Guillermo (Nature Research, 2014)
    chTOG is a conserved microtubule polymerase that catalyses the addition of tubulin dimers to promote microtubule growth. chTOG interacts with TACC3, a member of the transforming acidic coiled-coil (TACC) family. Here we ...

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