Browsing by Author "Bigas Salvans, Anna"

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  • A novel role of MNT as a negative regulator of REL and the NF-κB pathway
    Liaño-Pons, Judit; Lafita-Navarro, M. Carmen; García-Gaipo, Lorena; Colomer Montañà, Carlota, 1990-; Rodríguez, Javier; von Kriegsheim, Alex; Hurlin, Peter J.; Ourique, Fabiana; Delgado, M. Dolores; Bigas Salvans, Anna; Espinosa Blay, Lluís; León, Javier (Nature Research, 2021)
    MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix-loop-helix proteins that heterodimerize with MAX in a mutually exclusive manner, and bind ...
  • A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
    Robles-Valero, Javier; Lorenzo-Martín, L. Francisco; Menacho Márquez, Mauricio; Fernández-Pisonero, Isabel; Abad, Antonio; Camós, Mireia; Toribio, María Luisa; Espinosa Blay, Lluís; Bigas Salvans, Anna; Bustelo, Xose R. (Elsevier, 2017)
    Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their ...
  • A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Margalef González, Pol, 1985-; Fernández Majada, Vanessa; Villanueva, Alberto; Garcia Carbonell, Ricard; Iglesias Coma, Mar; López Muñoz, Laura; Martínez Iniesta, María; Villà i Freixa, Jordi; Mulero, María Carmen; Andreu García, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2012)
    Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains ...
  • Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling
    Estupiñán, Óscar; Rey, Verónica; Tornín, Juan; Murillo, Dzohara; Gallego, Borja; Huergo, Carmen; Blanco Lorenzo, Verónica; González Meana, M. Victoria; Rodríguez Pérez, Aida; Moris, Francisco; González Miranda, Jessica; Ayllón, Verónica; Ramos-Mejía, Verónica; Bigas Salvans, Anna; Rodríguez, René (Elsevier, 2023)
    Osteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-8042 is a well-tolerated mithramycin analog that has demonstrated an efficient ability to eliminate tumor cells, ...
  • Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis
    López Arribillaga, Erika, 1986-; Yan, Bing; Lobo-Jarne, Teresa; Guillén, Yolanda; Menéndez, Silvia; Andreu García, Montserrat; Bigas Salvans, Anna; Iglesias Coma, Mar; Espinosa Blay, Lluís (MDPI, 2021)
    Background: previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. ...
  • Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development
    Brena, David; Bertran, Joan; Porta de la Riva, Montserrat; Guillén, Yolanda; Cornes Maragliano, Eric, 1987-; Kukhtar, Dmytro; Campos-Vicens, Lluís; Fernández, Lierni; Pecharroman, Irene; García-López, Albert; Islam, Abul, 1978-; Marruecos, Laura; Bigas Salvans, Anna; Cerón Madrigal, Julián; Espinosa Blay, Lluís (Nature Research, 2020)
    Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect ...
  • Blood Development: Hematopoietic Stem Cell Dependence and Independence
    Dzierzak, Elaine; Bigas Salvans, Anna (Elsevier, 2018)
    Evidence of the diversity and multi-layered organization of the hematopoietic system is leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all long-lived hematopoietic cells derive ...
  • Blood stem cells: from beginning to end.
    Bigas Salvans, Anna; Waskow, Claudia (Company of Biologists, 2016)
    In June 2016, around 200 scientists from all over the world gathered at EMBL headquarters in Heidelberg, Germany to discuss the recent advances in hematopoietic stem cells from three different angles: developmental, adulthood ...
  • Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch
    López Arribillaga, Erika, 1986-; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent
    Margalef González, Pol, 1985-; Colomer Montañà, Carlota, 1990-; Villanueva, Alberto; Montagut Viladot, Clara; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Salazar, Ramón; Martínez Iniesta, María; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Association for the Advancement of Science, 2015)
    KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and ...
  • Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model
    Robles-Valero, Javier; Fernández-Nevado, Lucía; Cuadrado, Myriam; Lorenzo-Martín, L. Francisco; Fernández-Pisonero, Isabel; Abad, Antonio; Redín, Esther; Montuenga, Luis; Martín-Zanca, Dionisio; Bigas Salvans, Anna; Mallo, Moises; Dosil, Mercedes; Bustelo, Xose R. (Wiley, 2022)
    Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall-cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene-edited ...
  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Chromatin-linked and NF-kB independent IkBa function in embryonic stem cell pluripotency exit and differentation
    Galán i Palma, Luis (Universitat Pompeu Fabra, 2023-03-29)
    Pluripotent stem cells (PSCs) have the ability to self-renew and give rise to almost every somatic cell type. Because of their enormous potential as a tool for regenerative medicine, understanding molecular mechanisms that ...
  • Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance
    Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelon, Lara, 1972-; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer
    Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)
    NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
  • Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4
    Marruecos, Laura; Bertran, Joan; Álvarez-Villanueva, Daniel; Mulero, María Carmen; Guillén, Yolanda; Palma, Luis G.; Floor, Martin; Vert, Anna; Arce-Gallego, Sara; Pecharroman, Irene; Batlle Masó, Laura, 1993-; Villà i Freixa, Jordi; Ghosh, Gourisankar; Bigas Salvans, Anna; Espinosa Blay, Lluís (Wiley, 2021)
    IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional roles for IκB homologues have been described, including chromatin association and transcriptional regulation. Phosphorylated ...
  • Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
    Bueno, Clara; Calero-Nieto, Fernando J.; Wang, Xiaonan; Valdés-Mas, Rafael; Gutiérrez-Agüera, Francisco; Roca-Ho, Heleia; Ayllon, Verónica; Real, Pedro J.; Arambilet, David; Espinosa Blay, Lluís; Torres-Ruiz, Raul; Agraz-Doblas, Antonio; Varela, Ignacio; de Boer, Jasper; Bigas Salvans, Anna; Gottgens, Bertie; Marschalek, Rolf; Menéndez, Pablo (Ferrata Storti Foundation, 2019)
    The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the ...
  • Epigenetic silencing of tumor suppressor miR-124 directly supports STAT3 activation in cutaneous T-Cell lymphoma
    García-Colmenero, Lidia; González Miranda, Jessica; Sandoval, Juan; Guillén, Yolanda; Diaz-Lagares, Angel; Andrades, Evelyn; Iglesias, Arnau; Nonell Mazelon, Lara, 1972-; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís; Gallardo Hernández, Fernando (MDPI, 2020)
    Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, ...
  • GATA2 deficiency and MDS/AML: experimental strategies for disease modelling and future therapeutic prospects
    Kotmayer, Lili; Romero-Moya, Damià; Marin-Bejar, Oskar; Kozyra, Emilia; Català, Albert; Bigas Salvans, Anna; Wlodarski, Marcin W.; Bödör, Csaba; Giorgetti, Alessandra (Wiley, 2022)
    The importance of predisposition to leukaemia in clinical practice is being increasingly recognized. This is emphasized by the establishment of a novel WHO disease category in 2016 called "myeloid neoplasms with germline ...
  • Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials
    González-Gil, Celia; Bigas Salvans, Anna; Genescà, Eulalia (Ferrata Storti Foundation, 2022)
    Genetic information has been crucial to understand the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) at diagnosis and at relapse, but still nowadays has a limited value in a clinical context. Few genetic ...

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