Browsing by Author "Bessonov, Nickolay"

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  • Existence and dynamics of strains in a nonlocal reaction-diffusion model of viral evolution
    Bessonov, Nickolay; Bocharov, Gennady A.; Meyerhans, Andreas; Popov, Vladimir; Volpert, Vitaly (Society for Industrial and Applied Mathematics, 2021)
    In this work, we develop a mathematical framework for predicting and quantifying virus diversity evolution during infection of a host organism. It is specified as a virus density distribution with respect to genotype and ...
  • Nonlocal reaction–diffusion model of viral evolution: emergence of virus strains
    Bessonov, Nickolay; Bocharov, Gennady A.; Meyerhans, Andreas; Popov, Vladimir; Volpert, Vitaly (MDPI, 2020)
    This work is devoted to the investigation of virus quasi-species evolution and diversification due to mutations, competition for host cells, and cross-reactive immune responses. The model consists of a nonlocal reaction–diffusion ...
  • Spatial lymphocyte dynamics in lymph nodes predicts the cytotoxic T cell frequency needed for HIV infection control
    Grebennikov, Dmitry; Bouchnita, Anass; Volpert, Vitaly; Bessonov, Nickolay; Meyerhans, Andreas; Bocharov, Gennady A. (Frontiers, 2019)
    The surveillance of host body tissues by immune cells is central for mediating their defense function. In vivo imaging technologies have been used to quantitatively characterize target cell scanning and migration of ...
  • Spatiotemporal Dynamics of Virus Infection Spreading in Tissues
    Bocharov, Gennady A.; Meyerhans, Andreas; Bessonov, Nickolay; Trofimchuk, Sergei; Volpert, Vitaly (Public Library of Science (PLoS), 2016)
    Virus spreading in tissues is determined by virus transport, virus multiplication in host cells and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate determined by the infection level. ...