Browsing by Author "Besses Raebel, Carles"

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  • Anti-tumor activity of the combination of bendamustine with vorinostat in diffuse large B-cell lymphoma cells.
    Fernández Rodríguez, M. Concepción; Salar Silvestre, Antonio; Navarro, Alfons; Gimeno Vázquez, Eva; Pairet García, Silvia; Camacho Díaz, Laura; Ferraro Rosset, Mariana Paola; Serrano Figueras, Sergi; Besses Raebel, Carles; Bellosillo Paricio, Beatriz; Sanchez Gonzalez, Blanca (Taylor & Francis, 2016)
    Current standard-of-care therapy for diffuse large B-cell lymphoma (DLBCL) results in up to 40% of patients who either relapse or develop refractory disease. In this setting, further therapeutic improvements are needed. ...
  • Antiplatelet therapy versus observation in low-risk essential thrombocythemia with a CALR mutation
    Álvarez Larrán, Alberto; Besses Raebel, Carles (Ferrata Storti Foundation, 2016)
    The role of antiplatelet therapy as primary prophylaxis of thrombosis in low-risk essential thrombocythemia has not been studied in randomized clinical trials. We assessed the benefit/risk of low-dose aspirin in 433 patients ...
  • Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group.
    Geyer, Holly L.; Besses Raebel, Carles; Mesa, Ruben A. (Ferrata Storti Foundation, 2017)
    The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on ...
  • Characterization of CD34+ hematopoietic progenitor cells in JAK2V617F and CALR-mutated myeloproliferative neoplasms.
    Angona Figueras, Anna; Álvarez Larrán, Alberto; Bellosillo Paricio, Beatriz; Longarón Rozalen, Raquel; Camacho Díaz, Laura; Fernández Rodríguez, M. Concepción; Pairet García, Silvia; Besses Raebel, Carles (Elsevier, 2016)
    Mutations in JAK2 or CALR are observed in patients with myeloproliferative neoplasms (MPN). To get further insight in the dynamics of the mutant clone, we assessed the mutant allele burden in hematopoietic stem cells (HSCs), ...
  • Effect of mutation order on myeloproliferative neoplasms.
    Ortmann, Christina A.; Green, Anthony R.; Bellosillo Paricio, Beatriz; Besses Raebel, Carles (Massachusets medical society, 2015)
    BACKGROUND: Cancers result from the accumulation of somatic mutations, and their properties are thought to reflect the sum of these mutations. However, little is known about the effect of the order in which mutations are ...
  • Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene epigenetically regulated
    Martínez-Calle, Nicolás; Pascual, Marien; Ordóñez, Raquel; San José-Enériz, Edurne; Kulis, Marta; Miranda, Estíbaliz; Guruceaga, Elisabeth; Segura, Víctor; Larráyoz, María José; Bellosillo Paricio, Beatriz; Calasanz, María José; Besses Raebel, Carles; Rifón, José; Martín-Subero, José I.; Agirre, Xabier; Prosper, Felipe (Ferrata Storti Foundation, 2019)
    In this study we have interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpGs corresponding to 10,253 genes between myelofibrosis ...
  • How to treat essential thrombocythemia and polycythemia vera.
    Besses Raebel, Carles; Álvarez Larrán, Alberto (Elsevier, 2016)
    Polycythemia vera and essential thrombocythemia (ET) are chronic myeloproliferative neoplasms associated with thrombotic or hemorrhagic complications, and increased risk of transformation to myelofibrosis and acute myeloid ...
  • Identification of two novel EPOR gene variants in primary familial polycythemia: Case report and literature review
    Lo Riso, Laura; Vargas-Parra, Gardenia; Navarro, Gemma; Arenillas Rocha, Leonor; Fernández-Ibarrondo, Lierni; Robredo, Beatriz; Ballester, Carmen; López, Bernardo; Perez-Montaña, Albert; Sampol, Antonia; Florensa Brichs, Lourdes; Besses Raebel, Carles; Duran, María Antonia; Bellosillo Paricio, Beatriz (MDPI, 2022)
    Primary familial and congenital polycythemia is a rare disease characterized by an increase in red cell mass that may be due to pathogenic variants in the EPO receptor (EPOR) gene. To date, 33 genetic variants have been ...
  • Impact of genotype on leukaemic transformation in polycythaemia vera and essential thrombocythaemia
    Alvarez-Larrán, Alberto; Senín Magan, Maria Alicia; Fernández Rodríguez, M. Concepción; Pereira, Arturo; Arellano-Rodrigo, Arturo; Gómez, Montse; Ferrer-Marín, Francisca; Martínez-López, Joaquín; Camacho Díaz, Laura; Colomer Pujol, Dolors; Angona Figueras, Anna; Navarro, Blanca; Cervantes, Francisco; Besses Raebel, Carles; Bellosillo Paricio, Beatriz; Hernández-Boluda, Juan Carlos (Wiley, 2017)
    The influence of driver mutations on leukaemic transformation was analysed in 1747 patients with polycythaemia vera or essential thrombocythaemia. With a median follow-up of 7·2 years, 349 patients died and 62 progressed ...
  • Leukemic transformation and second cancers in 3649 patients with high-risk essential thrombocythemia in the EXELS study
    Birgegård, Gunnar; Folkvaljon, Folke; Garmo, Hans; Holmberg, Lars; Besses Raebel, Carles; Griesshammer, Martin; Gugliotta, Luigi; Wuh, Jingyang; Achenbach, Heinrich; Kiladjian, Jean-Jacques; Harrison, Claire N. (Elsevier, 2018)
    EXELS, a post-marketing observational study, is the largest prospective study of high-risk essential thrombocythemia (ET) patients, with an observation time of 5 years. EXELS found higher event rates of acute leukemia ...
  • Masked polycythaemia vera: presenting features, response to treatment and clinical outcomes.
    Álvarez Larrán, Alberto; Angona Figueras, Anna; Ancochea Serra, Agueda; García-Pallarols, Francesc; Fernández Rodríguez, M. Concepción; Longarón Rozalen, Raquel; Bellosillo Paricio, Beatriz; Besses Raebel, Carles (Wiley, 2016)
    Masked polycythaemia vera (PV) has been proposed as a new entity with poorer outcome than overt PV. In this study, the initial clinical and laboratory characteristics, response to treatment and outcome of masked and overt ...
  • MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis
    Fernández Rodríguez, M. Concepción; Bellosillo Paricio, Beatriz; Ferraro Rosset, Mariana Paola; Seoane, Agustín; Sanchez Gonzalez, Blanca; Pairet García, Silvia; Pons, A.; Barranco Sanz, Luis Carlos; Vela Ortíz, María del Carmen; Gimeno Vázquez, Eva; Colomo Saperas, Luis Alberto; Besses Raebel, Carles; Navarro, Alfons; Salar Silvestre, Antonio (International Institute of Anticancer Research (IIAR), 2017)
    BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic ...
  • miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia.
    Navarro, A.; Pairet García, Silvia; Álvarez Larrán, Alberto; Pons, A.; Ferrer, G.; Longarón Rozalen, Raquel; Fernández Rodríguez, M. Concepción; Camacho Díaz, Laura; Monzó, M.; Besses Raebel, Carles; Bellosillo Paricio, Beatriz (Nature Publishing Group, 2016)
    The biological basis of essential thrombocythemia (ET) patients lacking known mutations is still unknown. MicroRNAs (miRNA) regulate hematopoietic differentiation and are deregulated in several hematopoietic malignancies. ...
  • Molecular and cytogenetic characterization of myelodysplastic syndromes in cell-free DNA
    García Gisbert, Nieves, 1994-; Garcia-Ávila, Sara; Merchán, Brayan; Salido Galeote, Marta; Fernández Rodríguez, M. Concepción; Gibert Fernandez, Joan 1988-; Fernández-Ibarrondo, Lierni; Camacho Díaz, Laura; Lafuente, Marta; Longarón Rozalen, Raquel; Espinet Solà, Blanca; Vélez, Patricia; Pujol Vallverdú, Ramon Maria; Andrade-Campos, Marcio; Arenillas Rocha, Leonor; Salar Silvestre, Antonio; Calvo Gonzalo, Xavier; Besses Raebel, Carles; Bellosillo Paricio, Beatriz (American Society of Hematology, 2022)
    Molecular and cytogenetic studies are essential for diagnosis and prognosis in patients with myelodysplastic syndromes (MDSs). Cell-free DNA (cfDNA) analysis has been reported to be a reliable noninvasive approach for ...
  • Molecular characterisation of triple negative essential thrombocythaemia patients by platelet analysis and targeted sequencing.
    Angona Figueras, Anna; Fernández Rodríguez, M. Concepción; Álvarez Larrán, Alberto; Camacho Díaz, Laura; Longarón Rozalen, Raquel; Torres, Erica; Pairet García, Silvia; Besses Raebel, Carles; Bellosillo Paricio, Beatriz (Nature Publishing Group, 2016)
    Essential thrombocythaemia (ET) is a myeloproliferative neoplasm(MPN) characterised by megakaryocyte hyperplasia and thrombo-cytosis. From the genetic perspective, ET patients harbourmutations inJAK2(50–60%),CALR(15–30%) ...
  • Polycythemia vera and essential thrombocythemia patients exhibit unique serum metabolic profiles compared to healthy individuals and secondary thrombocytosis patients
    Gómez-Cebrián, Nuria; Rojas-Benedicto, Ayelén; Albors-Vaquer, Arturo; Bellosillo Paricio, Beatriz; Besses Raebel, Carles; Martínez-López, Joaquín; Pineda-Lucena, Antonio; Puchades-Carrasco, Leonor (MDPI, 2021)
    Most common myeloproliferative neoplasms (MPNs) include polycythemia vera (PV) and essential thrombocythemia (ET). Accurate diagnosis of these disorders remains a clinical challenge due to the lack of specific clinical or ...
  • Risk of thrombosis according to need of phlebotomies in patients with polycythemia vera treated with hydroxyurea.
    Álvarez Larrán, Alberto; Cruz, Yasmina; Montesdeoca Romero, Sara; García-Pallarols, Francesc; Besses Raebel, Carles; Grupo Español de Neoplasias Mieloproliferativas Filadelfia Negativas (Ferrata Storti Foundation, 2017)
    Hematocrit control below 45% is associated with a lower rate of thrombosis in polycythemia vera. In patients receiving hydroxyurea, this target can be achieved with hydroxyurea alone or with the combination of hydroxyurea ...
  • Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial.
    Verstovsek, Srdan; Besses Raebel, Carles; Kiladjian, Jean-Jacques (Ferrata Storti Foundation, 2016)
    RESPONSE is an open-label phase 3 study evaluating the Janus kinase 1/Janus kinase 2 inhibitor ruxolitinib versus best available therapy for efficacy/safety in hydroxyurea-resistant or intolerant patients with polycythemia ...
  • Symptom burden profile in myelofibrosis patients with thrombocytopenia: Lessons and unmet needs
    Scotch, Allison H.; Besses Raebel, Carles; Geyer, Holly L. (Elsevier, 2017)
    Myelofibrosis is a myeloproliferative neoplasm associated with progressive cytopenias and high symptom burden. MF patients with thrombocytopenia have poor prognosis but the presence of thrombocytopenia frequently precludes ...
  • Thromboembolic events in polycythemia vera
    Griesshammer, Martin; Kiladjian, Jean-Jacques; Besses Raebel, Carles (SpringerOpen, 2019)
    Thromboembolic events and cardiovascular disease are the most prevalent complications in patients with polycythemia vera (PV) compared with other myeloproliferative disorders and are the major cause of morbidity and mortality ...