Browsing by Author "Benito, David"

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  • Activation of final complement components after kidney transplantation as a marker of delayed graft function severity
    Arias Cabrales, Carlos Enrique; Riera Oliva, Marta; Pérez-Sáez, María José; Gimeno Beltran, Javier; Benito, David; Redondo Pachón, María Dolores; Burballa Tàrrega, Carla, 1988-; Crespo Barrio, Marta; Pascual Santos, Julio; Rodríguez, Eva (Oxford University Press, 2020)
    Background: Ischaemia-reperfusion (I/R) damage is a relevant cause of delayed graft function (DGF). Complement activation is involved in experimental I/R injury, but few data are available from kidney transplant (KT) ...
  • Both specific endothelial and proximal tubular Adam17 deletion protect against diabetic nephropathy
    Palau González, Vanesa; Nugraha, Bramasta; Benito, David; Pascual Santos, Julio; Emmert, Maximilian Y.; Hoerstrup, Simon P.; Riera, Marta; Soler, María José (MDPI, 2021)
    ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have previously demonstrated that renal ADAM17 is upregulated ...
  • Endothelial ADAM17 expression in the progression of kidney injury in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Jarrín, Josué; Villanueva, Sofia; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Disintegrin and metalloproteinase domain 17 (ADAM17) activates inflammatory and fibrotic processes through the shedding of various molecules such as Tumor Necrosis Factor-α (TNF-α) or Transforming Growht Factor-α (TGF-α). ...
  • Phosphorylation of S6RP in peritubular capillaries of kidney grafts and circulating HLA donor-specific antibodies
    Raïch-Regué, Dàlia; Gimeno, Javier; Llinàs-Mallol, Laura; Menéndez, Silvia; Benito, David; Redondo, Dolores; Pérez-Sáez, María José; Riera, Marta; Reed, Elaine F.; Pascual Santos, Julio; Crespo Barrio, Marta (Frontiers, 2022)
    Antibody-mediated rejection (ABMR) caused by donor-specific HLA-antibodies (DSA) is a mediator of allograft loss after kidney transplantation (KT). DSA can activate microvascular endothelium damage through the mTOR pathway. ...
  • Redefining the role of ADAM17 in renal proximal tubular cells and its implications in an obese mouse model of pre-diabetes
    Palau González, Vanesa; Villanueva, Sofia; Jarrín, Josué; Benito, David; Márquez, Eva; Rodríguez, Eva; Soler, María José; Oliveras, Anna; Gimeno Beltran, Javier; Sans Atxer, Laia; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Riera Oliva, Marta (MDPI, 2021)
    Acute and chronic kidney lesions induce an increase in A Disintegrin And Metalloproteinase domain 17 (ADAM17) that cleaves several transmembrane proteins related to inflammatory and fibrotic pathways. Our group has ...
  • Role of C5aR1 and C5L2 receptors in ischemia-reperfusion injury
    Arias Cabrales, Carlos Enrique; Rodriguez García, Eva; Gimeno Beltran, Javier; Benito, David; Pérez-Saez, María José; Redondo Pachón, María Dolores; Buxeda, Anna; Burballa Tàrrega, Carla, 1988-; Crespo Barrio, Marta; Riera, Marta; Pascual Santos, Julio (MDPI, 2021)
    The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI ...