Browsing by Author "Bellora Pereyra, Nicolás"

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  • A chromatin code for alternative splicing involving a putative association between CTCF and HP1alpha proteins
    Agirre Ortiz de Guzmán, Eneritz, 1983-; Bellora Pereyra, Nicolás; Alló, Mariano; Pagès Pinós, Amadís; Bertucci, Paola; Kornblihtt, Alberto R.; Eyras Jiménez, Eduardo (BioMed Central, 2015)
    BACKGROUND: Alternative splicing is primarily controlled by the activity of splicing factors and by the elongation of the RNA polymerase II (RNAPII). Recent experiments have suggested a new complex network of splicing ...
  • A quantitative profiling tool for diverse genomic data types reveals potential associations between chromatin and Pre-mRNA processing
    Kremsky, Isaac Jacob, 1983-; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo (Public Library of Science (PLoS), 2015)
    High-throughput sequencing, and genome-based datasets in general, are often represented as profiles centered at reference points to study the association of protein binding and other signals to particular regulatory ...
  • Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells
    La Greca, Alejandro; Bellora Pereyra, Nicolás; Le Dily, François; Jara, Rodrigo; Nacht, A. Silvina; Quilez Oliete, Javier; Villanueva Cañas, José Luis, 1984-; Vidal Barba, Enric; Merino, Gabriela; Fresno, Cristóbal; Reischle, Inti Tarifa; Vallejo, Griselda; Vicent, Guillermo Pablo; Fernández, Elmer; Beato, Miguel; Saragüeta, Patricia (eLife Sciences Publications, 2022)
    Estrogen (E2) and Progesterone (Pg), via their specific receptors (ERalpha and PR), are major determinants in the development and progression of endometrial carcinomas, However, their precise mechanism of action and the ...
  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • In silico analysis of regulatory motifs in gene promoters
    Bellora Pereyra, Nicolás (Universitat Pompeu Fabra, 2011-04-12)
    Regulation of gene transcription is a complex process involving many different proteins, some of which bind in a sequence-specific manner to DNA motifs in the gene promoter. The need to maintain specific interactions between ...
  • Interferon-gamma is a critical modulator of CB(2) cannabinoid receptor signaling during neuropathic pain
    Racz, Ildiko; Nadal i Roura, Xavier, 1980-; Alferink, Judith; Baños i Díez, Josep Eladi; Rehnelt, Jennifer; Martín, Miguel; Pintado, Belén; Gutierrez-Adan, Alfonso; Sanguino, Elena; Bellora Pereyra, Nicolás; Manzanares, Jorge; Zimmer, Andreas; Maldonado, Rafael, 1961- (Society for Neuroscience, 2008)
    Nerve injuries often lead to neuropathic pain syndrome. The mechanisms contributing to this syndrome involve local inflammatory responses, activation of glia cells, and changes in the plasticity of neuronal nociceptive ...
  • Leveraging transcript quantification for fast computation of alternative splicing profiles
    Alamancos, Gael P.; Pagès Pinós, Amadís; Trincado Alonso, Juan Luis, 1987-; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo (Cambridge University Press, 2015)
    Alternative splicing plays an essential role in many cellular processes and bears major relevance in the understanding of multiple diseases, including cancer. High-throughput RNA sequencing allows genome-wide analyses of ...
  • Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers
    Pérez-Guijarro, Eva; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo; Soengas, María S. (Nature Publishing Group, 2016)
    Nuclear 3’-end-polyadenylation is essential for the transport, stability and translation of virtually all eukaryotic mRNAs. Poly(A) tail extension can also occur in the cytoplasm, but the transcripts involved are incompletely ...
  • Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB
    Coelho, Miguel B.; Attig, Jan; Bellora Pereyra, Nicolás; König, Julian; Hallegger, Martina; Kayikci, Melis; Eyras Jiménez, Eduardo; Ule, Jernej; Smith, Christopher, W. J. (EMBO Press, 2015)
    Matrin3 is an RNA- and DNA-binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no widespread role in RNA ...
  • Positional bias of general and tissue-specific regulatory motifs in mouse gene promoters
    Bellora Pereyra, Nicolás; Farré, Domènec; Albà Soler, Mar (BioMed Central, 2007)
    Background: The arrangement of regulatory motifs in gene promoters, or promoter/narchitecture, is the result of mutation and selection processes that have operated over many/nmillions of years. In mammals, tissue-specific ...
  • Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation
    Fernandez, Noemí; Fernandez Miragall, Olga; Ramajo, Jorge; García Sacristán, Ana; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo; Briones, Carlos; Martinez Salas, Encarnación (Oxford University Press, 2011)
    RNA structure plays a fundamental role in internal initiation of translation. Picornavirus internal ribosome entry site (IRES) are long, efficient cis-acting elements that recruit the ribosome to internal mRNA sites. ...
  • The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
    Llorian, Miriam; Gooding, Clare; Bellora Pereyra, Nicolás; Hallegger, Martina; Buckroyd, Adrian; Wang, Xiao; Rajgor, Dipen; Kayikci, Melis; Feltham, Jack; Ule, Jernej; Eyras Jiménez, Eduardo; Smith, Christopher, W. J. (Oxford University Press, 2016)
    Alternative splicing (AS) is a key component of gene expression programs that drive cellular differentiation. Smooth muscle cells (SMCs) are important in the function of a number of physiological systems; however, investigation ...
  • The translational landscape of the splicing factor SRSF1 and its role in mitosis
    Maslon, Magdalena M.; Heras, Sara R.; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo; Cáceres, Javier F. (eLife, 2014)
    The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally ...

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