Browsing by Author "Bauer-Mehren, Anna"

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  • Automatic filtering and substantiation of drug safety signals
    Bauer-Mehren, Anna; van Mulligen, Erik M.; Avillach, Paul; Carrascosa Baena, María Carmen, 1972-; García Serna, Ricard; Piñero González, Janet, 1977-; Singh, Barat; Lopes, Pedro; Oliveira, José Luis; Diallo, Gayo; Ahlberg Helgee, Ernst; Boyer, Scott; Mestres i López, Jordi; Sanz, Ferran; Kors, Jan A.; Furlong, Laura I., 1971- (Public Library of Science (PLoS), 2012)
    Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great ...
  • DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes.
    Piñero González, Janet, 1977-; Queralt Rosinach, Núria; Bravo Serrano, Àlex, 1984-; Déu Pons, Jordi; Bauer-Mehren, Anna; Baron, Martin; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2015)
    DisGeNET is a comprehensive discovery platform designed to address a variety of questions concerning the genetic underpinning of human diseases. DisGeNET contains over 380,000 associations between >16,000 genes and 13,000 ...
  • Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system
    Coloma, Preciosa M.; Furlong, Laura I., 1971-; Bauer-Mehren, Anna; Sanz, Ferran; Mestres i López, Jordi; Sturkenboom, Miriam (Public Library of Science (PLoS), 2013)
    Background: Drug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are ...
  • From SNPs to pathways: integration of functional effect of sequence variations on models of cell signalling pathways
    Bauer-Mehren, Anna; Furlong, Laura I., 1971-; Rautschka, Michael; Sanz, Ferran (BioMed Central, 2009)
    Background: Single nucleotide polymorphisms (SNPs) are the most frequent type of sequence variation between individuals, and represent a promising tool for finding genetic determinants of complex diseases and understanding ...
  • Gathering and exploring scientific knowledge in pharmacovigilance
    Lopes, Pedro; Nunes, Tiago; Campos, David; Furlong, Laura I., 1971-; Bauer-Mehren, Anna; Sanz, Ferran; Carrascosa Baena, María Carmen, 1972-; Mestres i López, Jordi; Kors, Jan A.; Singh, Barat; van Mulligen, Erik M.; van der Lei, Johan; Diallo, Gayo; Avillach, Paul; Ahlberg Helgee, Ernst; Boyer, Scott; Díaz, Carlos; Oliveira, José Luis (Public Library of Science (PLoS), 2013)
    Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this ...
  • Integrative approaches to investigate the molecular basis of diseases and adverse drug reactions: from multivariate statistical analysis to systems biology
    Bauer-Mehren, Anna (Universitat Pompeu Fabra, 2011-04-12)
    Despite some great success, many human diseases cannot be effectively treated, prevented or cured, yet. Moreover, prescribed drugs are often not very efficient and cause undesired side effects. Hence, there is a need to ...
  • Pathway databases and tools for their exploitation: benefits, current limitations and challenges
    Bauer-Mehren, Anna; Furlong, Laura I., 1971-; Sanz, Ferran (Nature Publishing Group, 2009)
    In past years, comprehensive representations of cell signalling pathways have been developed by manual curation from literature, which requires huge effort and would benefit from information stored in databases and from ...
  • The EU-ADR Web Platform: delivering advanced pharmacovigilance tools
    Oliveira, José Luis; Lopes, Pedro; Nunes, Tiago; Campos, David; Boyer, Scott; Ahlberg Helgee, Ernst; van Mulligen, Erik M.; Kors, Jan A.; Singh, Barat; Furlong, Laura I., 1971-; Sanz, Ferran; Bauer-Mehren, Anna; Carrascosa Baena, María Carmen, 1972-; Mestres i López, Jordi; Avillach, Paul; Diallo, Gayo; Díaz, Carlos; van der Lei, Johan (John Wiley & Sons, 2013)
    PURPOSE: Pharmacovigilance methods have advanced greatly during the last decades, making post-market drug assessment an essential drug evaluation component. These methods mainly rely on the use of spontaneous reporting ...

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