Browsing by Author "Batlle Gómez, Eduard"

Sort by: Order: Results:

  • Casagolda, David; Valle Pérez, Beatriz del; Valls, Gabriela; Lugilde, Ero; Vinyoles, Meritxell; Casado Vela, Juan; Solanas, Guiomar; Batlle Gómez, Eduard; Reynolds, Albert B.; Casal, José Ignacio; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2010)
    p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1ε ...
  • Tauriello, Daniele V.F.; Calon, Alexandre; Lonardo, Enza; Batlle Gómez, Eduard (Wiley, 2017)
    Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early-stage ...
  • Barriga de Vicente, Francisco Martín, 1983- (Universitat Pompeu Fabra, 2013-11-28)
    The first chapter of this thesis describes the study of intestinal stem cells (ISCs) and their relationship to colon cancer. We describe the transcriptional landscape of intestinal epithelial populations through the use ...
  • Barriga de Vicente, Francisco Martín, 1983-; Montagni, Elisa, 1984-; Mana, Miyeko; Méndez Lago, María; Hernando-Momblona, Xavier; Sevillano, Marta; Guillaumet-Adkins, Amy; Rodríguez Esteban, Gustavo; Buczacki, Simon J.A.; Gut, Marta; Heyn, Holger; Winton, Douglas J.; Yilmaz, Omer H.; Attolini, Camille Stephan-Otto; Gut, Ivo Glynne; Batlle Gómez, Eduard (Elsevier, 2017)
    Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell (ISC) populations have been described, the identity and features ...
  • Forn, Marta; Díez-Villanueva, Anna; Merlos-Suárez, Anna; Muñoz, Mar; Lois, Sergi; Carriò, Elvira; Jordà, Mireia; Bigas Salvans, Anna; Batlle Gómez, Eduard; Peinado, Miguel A. (Public Library of Science, 2015)
    Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important ...
  • Linares Aceituno, Jenniffer Lissethe; Varese, Monica; Sallent-Aragay, Anna; Méndez, Ana; Palomo-Ponce, Sergio; Iglesias Coma, Mar; Batlle Gómez, Eduard; Pisonero, Jorge; Montagut Viladot, Clara; Giralt, Ernest; Lo Re, Daniele; Calon, Alexandre (American Chemical Society (ACS), 2023)
    The relative success of platinum (Pt)-based chemotherapy comes at the cost of severe adverse side effects and is associated with a high risk of pro-oncogenic activation in the tumor microenvironment. Here, we report the ...
  • Cortina Duran, Carme (Universitat Pompeu Fabra, 2009-09-10)
    In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin ...
  • Campbell, Kira; Whissell, Gavin, 1978-; Franco-Marro, Xavier; Batlle Gómez, Eduard; Casanova, Jordi (Elsevier, 2011)
    The epithelial-to-mesenchymal transition (EMT) converts cells from static epithelial to migratory mesenchymal states (Hay, 1995). Here, we demonstrate that EMT in the Drosophila endoderm is dependent on the GATA-factor ...
  • Calon, Alexandre; Lonardo, Enza; Berenguer-Llergo, Antonio; Espinet, Elisa; Hernando-Momblona, Xavier; Iglesias Coma, Mar; Sevillano, Marta; Palomo-Ponce, Sergio; Tauriello, Daniele V.F.; Byrom, Daniel; Cortina Duran, Carme; Morral, Clara; Barceló, Carles; Tosi, Sebastien; Riera, Antoni; Attolini, Camille Stephan-Otto; Rossell, David; Sancho, Elena; Batlle Gómez, Eduard (Nature Publishing Group, 2015)
    Recent molecular classifications of colorectal cancer (CRC) based on global gene expression profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon evaluation of these classification systems, ...
  • Merlos-Suárez, Anna; Barriga de Vicente, Francisco Martín, 1983-; Jung, Peter; Iglesias Coma, Mar; Céspedes, María Virtudes; Rossell, David; Sevillano, Marta; Hernando-Momblona, Xavier; Silva-Diz, Victoria da; Muñoz, Purificación; Clevers, Hans; Sancho, Elena; Mangues, Ramon; Batlle Gómez, Eduard (Elsevier, 2011)
    A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients. ...
  • Morral Martínez, Clara, 1989- (Universitat Pompeu Fabra, 2017-07-17)
    El càncer de colon es caracteritza per presentar una composició cel·lular heterogènia en la qual només un subgrup de cèl·lules retenen la capacitat de contribuir en el manteniment i creixement del tumor. L‘investigació ...
  • Montagni, Elisa, 1984- (Universitat Pompeu Fabra, 2015-11-09)
    The first chapter identifies the transcription factor GATA6 as negative regulator of a transcriptional circuit dedicated to prevent the expansion of Adenoma Stem Cells (AdSCs) during the onset of colorectal cancer (CRC). ...
  • Fernández-Barral, Asunción; Costales-Carrera, Alba; Buira, Sandra P.; Jung, Peter; Ferrer Mayorga, Gemma; Larriba, María Jesús; Bustamante-Madrid, Pilar; Domínguez, Orlando; Real, Francisco X.; Guerra Pastrián, Laura; Lafarga, Miguel; García-Olmo, Damián; Cantero, Ramón; Del Peso, Luis; Batlle Gómez, Eduard; Rojo, Federico; Muñoz, Alberto; Barbáchano, Antonio (Wiley-Blackwell, 2019)
    Intestine is a major target of vitamin D and several studies indicate an association between vitamin D deficiency and inflammatory bowel diseases (IBD), but also increased colorectal cancer (CRC) risk and mortality. However, ...
  • Whissell, Gavin, 1978- (Universitat Pompeu Fabra, 2013-12-03)
    The recent discovery that intestinal adenomas are built on a stem cell hierarchy has raised great interest in understanding the signals that maintain tumor stem cells. We unveiled the existence of a transcriptional circuit ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking