Browsing by Author "Bajew, Simon, 1994-"

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  • Exon junction complex shapes the transcriptome by repressing recursive splicing
    Blazquez, Lorea; Emmett, Warren; Faraway, Rupert; Pineda, Jose Mario Bello; Bajew, Simon, 1994-; Gohr, André; Haberman, Nejc; Sibley, Christopher R.; Bradley, Robert K.; Irimia, Manuel; Ule, Jernej (Elsevier, 2018)
    Recursive splicing (RS) starts by defining an "RS-exon," which is then spliced to the preceding exon, thus creating a recursive 5' splice site (RS-5ss). Previous studies focused on cryptic RS-exons, and now we find that ...
  • SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
    Casteels, Tamara; Bajew, Simon, 1994-; Reiniš, Jiří; Enders, Lennart; Schuster, Michael; Fontaine, Frédéric; Müller, André C.; Wagner, Bridget K.; Bock, Christoph; Kubicek, Stefan (Elsevier, 2022)
    Insulin expression is primarily restricted to the pancreatic β cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-β cells, particularly in the ...
  • SRRM3 regulates a subprogram of highly sensitive microexons important for pancreatic endocrine function
    Bajew, Simon, 1994- (2022-04-12)
    Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This Thesis focuses on ...