Browsing by Author "Avolio, Rosario"

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  • Cholesterol homeostasis modulates platinum sensitivity in human ovarian cancer
    Criscuolo, Daniela; Avolio, Rosario; Calice, Giovanni; Laezza, Chiara; Paladino, Simona; Navarra, Giovanna; Maddalena, Francesca; Crispo, Fabiana; Pagano, Cristina; Bifulco, Maurizio; Landriscina, Matteo; Matassa, Danilo Swann; Esposito, Franca (MDPI, 2020)
    Despite initial chemotherapy response, ovarian cancer is the deadliest gynecologic cancer, due to frequent relapse and onset of drug resistance. To date, there is no affordable diagnostic/prognostic biomarker for early ...
  • Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1
    Avolio, Rosario; Inglés Ferrándiz, Marta, 1989-; Ciocia, Annagiulia; Coll, Olga; Bonnin, Sarah; Guitart, Tanit; Ribó Rubio, Anna; Gebauer, Fátima (Elsevier, 2022)
    Oncogene-induced senescence (OIS) is a form of stable cell-cycle arrest arising in response to oncogenic stimulation. OIS must be bypassed for transformation, but the mechanisms of OIS establishment and bypass remain poorly ...
  • Modulation of mitochondrial metabolic reprogramming and oxidative stress to overcome chemoresistance in cancer
    Avolio, Rosario; Matassa, Danilo Swann; Criscuolo, Daniela; Landriscina, Matteo; Esposito, Franca (MDPI, 2020)
    Metabolic reprogramming, carried out by cancer cells to rapidly adapt to stress such as hypoxia and limited nutrient conditions, is an emerging concepts in tumor biology, and is now recognized as one of the hallmarks of ...
  • Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation
    Avolio, Rosario; Järvelin, Aino I.; Mohammed, Shabaz; Agliarulo, Ilenia; Condelli, Valentina; Zoppoli, Pietro; Calice, Giovanni; Sarnataro, Daniela; Bechara, Elias; Tartaglia, Gian Gaetano; Landriscina, Matteo; Castello, Alfredo; Esposito, Franca; Matassa, Danilo Swann (Oxford University Press, 2018)
    Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important ...
  • TRAP1 regulation of cancer metabolism: dual role as oncogene or tumor suppressor
    Matassa, Danilo Swann; Agliarulo, Ilenia; Avolio, Rosario; Landriscina, Matteo; Esposito, Franca (MDPI, 2018)
    Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein ...