Browsing by Author "Arribas, Joaquín"

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  • Arenas, Enrique J.; Martínez Sabadell, Alex; Rius Ruiz, Irene; Román Alonso, Macarena; Escorihuela, Marta; Luque, Antonio; Fajardo, Carlos Alberto; Gros, Alena; Klein, Christian; Arribas, Joaquín (Nature Research, 2021)
    Immunotherapy has raised high expectations in the treatment of virtually every cancer. Many current efforts are focused on ensuring the efficient delivery of active cytotoxic cells to tumors. It is assumed that, once these ...
  • Fiascarelli, Alessio; Merlino, Giuseppe; Capano, Stefania; Talucci, Simone; Bisgnano, Diego; Bressan, Alessandro; Bellarosa, Daniela; Carrisi, Corrado; Paoli, Alessandro; Bigioni, Mario; Tunici, Patrizia; Irrissuto, Clelia; Salerno, Massimiliano; Arribas, Joaquín; de Stanchina, Elisa; Scaltriti, Maurizio; Binaschi, Monica (Springer, 2023)
    Purpose Dysregulation of the PI3K pathway is one of the most common events in breast cancer. Here we investigate the activity of the PI3K inhibitor MEN1611 at both molecular and phenotypic levels by dissecting and comparing ...
  • Adam-Artigues, Anna; Arenas, Enrique J.; Arribas, Joaquín; Prat, Aleix; Cejalvo, Juan Miguel (Elsevier, 2023)
    HER2 is a driver in solid tumors, mainly breast, oesophageal and gastric cancer, through activation of oncogenic signaling pathways such as PI3K or MAPK. HER2 overexpression associates with aggressive disease and poor ...
  • Saura, Cristina; Arribas, Joaquín; Sansó Martínez, Miriam, 1979- (American Association for Cancer Research (AACR), 2023)
    Breast cancer occurring during pregnancy (PrBC) and postpartum (PPBC) is usually diagnosed at more advanced stages compared with other breast cancer, worsening its prognosis. PPBC is particularly aggressive, with increased ...
  • Aran, Andrea; Peg, Vicente; Rabanal, Rosa María; Bernadó, Cristina; Zamora, Esther; Molina, Elisa; Arribas, Yago A.; Arribas, Joaquín; Pérez, José; Roura-Mir, Carme; Carrascal, Montserrat; Cortés, Javier; Martí, Mercè (Frontiers, 2021)
    EBV-specific T cells have been recently described to be involved in fatal encephalitis and myocarditis in cancer patients after immune checkpoint therapies. Here, we report the study of a human triple-negative breast cancer ...
  • Quintana, Ángela; Arenas, Enrique J.; Bernadó Morales, Cristina; Fernández Navarro, José; González, Jonatan; Esteve-Codina, Anna; Moliné, Teresa; Martí, Mercè; Curigliano, Giuseppe; Schmid, Peter; Peg, Vicente; Arribas, Joaquín; Cortés, Javier (Frontiers, 2023)
    Introduction: Tumor infiltrating lymphocytes (TILs) are known to be a prognostic and predictive biomarker in breast cancer, particularly in triple negative breast cancer (TNBC) patients. International guidelines have been ...
  • Gámez-Chiachio, Manuel; Molina-Crespo, Ángela; Ramos-Nebot, Carmen; Martinez-Val, Jeannette; Martinez, Lidia; Gassner, Katja; Llobet, Francisco J.; Soriano, Mario; Hernandez, Alberto; Cordani, Marco; Bernadó Morales, Cristina; Diaz, Eva; Rojo-Sebastian, Alejandro; Triviño Salazar, Juan Carlos; Sánchez, Laura; Rodríguez-Barrueco, Ruth; Arribas, Joaquín; Llobet-Navas, David; Sarrió, David; Moreno-Bueno, Gema (BioMed Central, 2022)
    Background: Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance ...
  • Bellio, Chiara; Emperador, Marta; Castellano, Pol; Gris-Oliver, Albert; Canals, Francesc; Sánchez Pla, Alexandre; Zamora, Esther; Arribas, Joaquín; Saura, Cristina; Serra, Violeta; Tabernero Cartula, Josep; Littlefield, Bruce A.; Villanueva, Josep (MDPI, 2022)
    Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after drug treatment. We performed proteomic characterization of the breast cancer (BC) DTP cell secretome after eribulin treatment. We showed ...
  • Palafox, Marta; Gonzalez-Perez, Abel; Arribas, Joaquín; López Bigas, Núria; Serra, Violeta (Nature Research, 2022)
    CDK4/6 inhibitors combined with endocrine therapy have demonstrated higher antitumor activity than endocrine therapy alone for the treatment of advanced estrogen receptor-positive breast cancer. Some of these tumors are ...
  • Duro-Sánchez, Santiago; Román Alonso, Macarena; Arribas, Joaquín (MDPI, 2023)
    A wide range of treatments are available for HER2-positive breast cancer, which have greatly improved the prognosis and quality of life of these patients. However, resistance to HER2-targeted or untargeted therapies is ...
  • Pascual-Reguant, Laura; Datta, Debayan; Cianferoni, Damiano; Kourtis, Savvas; Gañez-Zapater, Antoni; Cannatá, Chiara; Espinar, Lorena; García López, Laura; Musa-Afaneh, Sara; Guirola, Maria; Gkanogiannis, Anestis; Miró Canturri, Andrea; Arribas, Joaquín; Serrano Pubull, Luis, 1982-; Sdelci, Sara (EMBO Press, 2023)
    Triple-negative breast cancer (TNBC) often develops resistance to single-agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 ...
  • Pérez-Núñez, Iván; Rozalén, Catalina; Palomeque, José Ángel; Sangrador, Irene; Dalmau, Mariona; Comerma Blesa, Laura, 1983-; Hernández Prat, Anna, 1984-; Casadevall Aguilar, David; Menendez Romero, Silvia; Liu, Dan; Berenguer De Felipe, Jordi; Peña Arranz, Raúl, 1976-; Montañés, José Carlos; Albà Soler, Mar; Bonnin, Sarah; Ponomarenko, Julia; Servitja Tormo, Sonia; Arribas, Joaquín; Albanell Mestres, Joan; Celià-Terrassa, Toni (Nature Research, 2022)
    Ligand-dependent corepressor (LCOR) mediates normal and malignant breast stem cell differentiation. Cancer stem cells (CSCs) generate phenotypic heterogeneity and drive therapy resistance, yet their role in immunotherapy ...
  • Cebrià i Costa, Joan Pau, 1989-; Pascual-Reguant, Laura; Gonzalez-Perez, Abel; Serra Bardenys, Gemma, 1992-; Querol, J.; Cosín, M.; Verde, Gaetano; Cigliano, Riccardo Aiese; Sanseverino, Walter; Segura-Bayona, Sandra; Iturbide Martínez de Albéniz, Ane, 1989-; Andreu Martínez, David; Nuciforo, Paolo G.; Bernado-Morales, C.; Rodilla, Verónica; Arribas, Joaquín; Yélamos López, José; García de Herreros, Antonio; Stracker, Travis; Peiró Sales, Sandra (Nature Research, 2020)
    Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) ...
  • Mateo, Lidia; Duran-Frigola, Miquel, 1985-; Gris-Oliver, Albert; Palafox, Marta; Scaltriti, Maurizio; Razavi, Pedram; Chandarlapaty, Sarat; Arribas, Joaquín; Bellet, Meritxell; Serra, Violeta; Aloy, Patrick, 1972- (BioMed Central, 2020)
    Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence ...
  • Martínez Sabadell, Alex; Ovejero Romero, Pablo; Arribas, Joaquín; Arenas, Enrique J. (Elsevier, 2022)
    Immunotherapy has revolutionized cancer treatment, but preclinical models are required to understand immunotherapy resistance mechanisms underlying patient relapse. This protocol describes how to generate an acquired ...
  • Adam-Artigues, Anna; Rovira Guerín, Ana; Albanell Mestres, Joan; Arribas, Joaquín; Cejalvo, Juan M. (American Association for the Advancement of Science (AAAS), 2022)
    Anti-HER2 therapies have markedly improved prognosis of HER2-positive breast cancer. However, different mechanisms play a role in treatment resistance. Here, we identified AXL overexpression as an essential mechanism of ...
  • Lambies Barjau, Guillem, 1990-; Miceli, Martina; Martínez-Guillamon, Catalina; Olivera-Salguero, Rubén; Peña, Raúl; Frías, Carolina-Paola; Calderón, Irene; Atanassov, Boyko S.; Dent, Sharon Y.R.; Arribas, Joaquín; García de Herreros, Antonio; Díaz Cortés, Víctor Manuel, 1956- (American Association for Cancer Research (AACR), 2019)
    In cancer cells, epithelial-to-mesenchymal transition (EMT) is controlled by Snail1, a transcriptional factor also required for the activation of cancer-associated fibroblasts (CAF). Snail1 is short-lived in normal epithelial ...
  • Martínez Sabadell, Alex; Morancho Armisen, Beatriz; Rius Ruiz, Irene; Román Alonso, Macarena; Ovejero Romero, Pablo; Escorihuela, Marta; Chicote, Irene; Palmer, Héctor G.; Nonell Mazelon, Lara, 1972-; Alemany-Chavarria, Mercè; Klein, Christian; Bacac, Marina; Arribas, Joaquín; Arenas, Enrique J. (Elsevier, 2022)
    Despite the revolution of immunotherapy in cancer treatment, patients eventually progress due to the emergence of resistance. In this scenario, the selection of the tumor antigen can be decisive in the success of the ...
  • Duro-Sánchez, Santiago; Nadal-Serrano, Mercedes; Lalinde-Gutiérrez, Marta; Arenas, Enrique J.; Bernadó Morales, Cristina; Morancho Armisen, Beatriz; Escorihuela, Marta; Pérez-Ramos, Sandra; Escrivá-de-Romaní, Santiago; Gandullo-Sánchez, Lucía; Pandiella, Atanasio; Esteve-Codina, Anna; Rodilla, Verónica; Dijcks,Fred A.; Dokter, Wim H.A.; Cortés, Javier; Saura, Cristina; Arribas, Joaquín (American Association for Cancer Research (AACR), 2022)
    Antibody-drug conjugates (ADC) are antineoplastic agents recently introduced into the antitumor arsenal. T-DM1, a trastuzumab-based ADC that relies on lysosomal processing to release the payload, is approved for HER2-positive ...

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