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Browsing by Author "Argilaguet Marqués, Jordi, 1977-"

Browsing by Author "Argilaguet Marqués, Jordi, 1977-"

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  • A new model for the estimation of cell proliferation dynamics using CFSE data
    Banks, H. Thomas; Sutton, Karyn L.; Thompson, W. Clayton; Bocharov, Gennady A.; Doumic, Marie; Schenkel, Tim; Argilaguet Marqués, Jordi, 1977-; Giest, Sandra; Peligero Cruz, Cristina, 1986-; Meyerhans, Andreas (Elsevier, 2011)
    CFSE analysis of a proliferating cell population is a popular tool for the study of cell division and divisionlinked changes in cell behavior. Recently Banks et al. (2011), Luzyanina et al. (2009), Luzyanina et al. (2007), ...
  • A novel statistical analysis and interpretation of flow cytometry data
    Banks, H. Thomas; Kapraun, Dustin F.; Thompson, W. Clayton; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Taylor & Francis (Routledge), 2013)
    A recently developed class of models incorporating the cyton model of population generation structure into a conservation-based model of intracellular label dynamics is reviewed. Statistical aspects of the data collection ...
  • Analysis of variability in estimates of cell proliferation parameters for cyton-based models using CFSE-based flow cytometry data
    Banks, H. Thomas; Kapraun, Dustin F.; Link, Kathryn; Thompson, W. Clayton; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (De Gruyter, 2015)
    In this article we assess variability in cell proliferation dynamics observed for CD4+ and CD8+ T cells collected from two healthy donors. We review a recently developed class of models that incorporates the so-called ...
  • Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients.
    Latorre, Irene; Esteve-Solé, Ana; Redondo Pachón, María Dolores; Giest, Sandra; Argilaguet Marqués, Jordi, 1977-; Álvarez, Sara; Peligero Cruz, Cristina, 1986-; Forstmann, Isabelle; Crespo Barrio, Marta; Pascual Santos, Julio; Meyerhans, Andreas (Elsevier, 2016)
    BACKGROUND: Regulatory B (Breg) and T (Treg) cells represent a biomarker for tolerance in transplant patients. Despite the importance of Treg and Breg in transplantation and the suggested crosstalk between both suppressive ...
  • Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
    Bosch-Camós, Laia; Alonso, Uxía; Esteve-Codina, Anna; Chang, Chia-Yu; Martín-Mur, Beatriz; Accensi, Francesc; Muñoz, Marta; Navas, María J.; Dabad, Marc; Vidal, Enric; Pina-Pedrero, Sonia; Pleguezuelos, Patricia; Caratù, Ginevra; Salas, María L.; Liu, Lihong; Bataklieva, Stanimira; Gavrilov, Boris; Rodríguez, Fernando; Argilaguet Marqués, Jordi, 1977- (Public Library of Science (PLoS), 2022)
    African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease in wild boars and ...
  • Evaluating the importance of mitotic asymmetry in cyton-based models for FSE-based flow cytometry data
    Banks, H. Thomas; Kapraun, Dustin F.; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Academic Publications, 2015)
    We carry out computational inverse problem investigations to determine the importance of allowing for unequal label allocation to daughter cells during mitosis. Parameter estimations are performed using previously developed ...
  • Examining the cooperativity mode of antibody and CD8 + T cell immune responses for vaccinology
    Bocharov, Gennady A.; Grebennikov, Dmitry; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Elsevier, 2021)
    A fundamental unsolved issue in vaccine design is how neutralizing antibodies and cytotoxic CD8+ T cells cooperate numerically in controlling virus infections. We hypothesize on a viewpoint for the multiplicative cooperativity ...
  • Immunotherapy of chronic virus infections : Exhausted CD8+ T cell subsets are differentially regulated by XCR1 + DC
    Domenjó Vila, Eva, 1993- (2022-06-01)
    The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized. Using the mouse model ...
  • Linking cell dynamics with coexpression networks to characterize key events in chronic virus infection
    Riera Domínguez, María Graciela (Universitat Pompeu Fabra, 2018-12-10)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Linking cell dynamics with gene coexpression networks to characterize key events in chronic virus infections
    Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina, 1991-; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Live attenuated African swine fever viruses as ideal tools to dissect the mechanisms involved in viral pathogenesis and immune protection
    Lacasta, Anna; Monteagudo, Paula; Jiménez-Marín, Ángeles; Accensi, Francesc; Ballester Cardell, Maria; Argilaguet Marqués, Jordi, 1977-; Galindo-Cardiel, Iván; Segalés, Joaquim; Salas Larrazabal, María; Domínguez, Javier; Moreno, Ángela; Garrido, Juan; Rodríguez, Fernando (BioMed Central, 2015)
    African swine fever virus (ASFV) is the causal agent of African swine fever, a hemorrhagic and often lethal porcine disease causing enormous economical losses in affected countries. Endemic for decades in most of the ...
  • Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21
    Carreras Sureda, Amado, 1986-; Rubio Moscardó, Fanny; Olvera, Alex; Argilaguet Marqués, Jordi, 1977-; Kiefer, Kerstin, 1986-; Mothe, Beatriz; Meyerhans, Andreas; Brander, Christian; Vicente García, Rubén, 1978- (Public Library of Science (PLoS), 2016)
    Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression ...
  • Numbers game and immune geography as determinants of coronavirus pathogenicity
    Bocharov, Gennady A.; Casella, Valentina, 1991-; Argilaguet Marqués, Jordi, 1977-; Grebennikov, Dmitry; Güerri Fernández, Roberto; Ludewig, Burkhard; Meyerhans, Andreas (Frontiers, 2020)
  • PD-L1 blockade differentially impacts regulatory T cells from HIV-infected individuals depending on plasma viremia
    Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Güerri Fernández, Roberto; Torres, Berta; Ligero, Carmen; Colomer, Pilar; Plana, Montserrat; Knobel Freud, Hernando; García, Felipe; Meyerhans, Andreas (Public Library of Science (PLoS), 2015)
    Blocking the PD-1/PD-L1 pathway has emerged as a potential therapy to restore impaired immune responses in human immunodeficiency virus (HIV)-infected individuals. Most reports have studied the impact of the PD-L1 blockade ...
  • Prediction of PD-L1 inhibition effects for HIV-infected individuals
    Zheltkova, Valerya; Argilaguet Marqués, Jordi, 1977-; Peligero Cruz, Cristina, 1986-; Bocharov, Gennady A.; Meyerhans, Andreas (Public Library of Science (PLoS), 2019)
    The novel therapies with immune checkpoint inhibitors hold great promises for patients with chronic virus infections and cancers. This is based mainly on the partial reversal of the exhausted phenotype of antigen-specific ...
  • Spatiotemporal differences of early type I interferon response in acute and chronic viral infections
    Casella, Valentina, 1991- (2021-06-02)
    The main aim of this project was to uncover the spatiotemporal events influencing type I interferon (IFN-I) dynamics during the early phase of acute and chronic viral infections. Time-resolved spleen-transcriptome analysis ...
  • Systems analysis reveals complex biological processes during virus infection fate decisions
    Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina, 1991-; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
  • The transcription factor NFAT5 limits infection-induced type I interferon responses
    Huerga Encabo, Hector, 1989-; Traveset Martínez, Laia, 1992-; Argilaguet Marqués, Jordi, 1977-; Angulo Aguado, Ana; Nistal-Villán, Estanislao; Jaiswal, Rahul; Escalante, Carlos R.; Gekas, Christos; Meyerhans, Andreas; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2020)
    Type I interferon (IFN-I) provides effective antiviral immunity but can exacerbate harmful inflammatory reactions and cause hematopoietic stem cell (HSC) exhaustion; therefore, IFN-I expression must be tightly controlled. ...
  • Time-resolved systems analysis of virus infection fate regulation
    Pedragosa Marín, Mireia (Universitat Pompeu Fabra, 2018-03-21)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus - immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
  • Understanding experimental LCMV infection of mice: the role of mathematical models
    Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Hindawi, 2015)
    Virus infections represent complex biological systems governed by multiple-level regulatory processes of virus replication and host immune responses. Understanding of the infection means an ability to predict the systems ...