Browsing by Author "Aranda Aragón, Sergio"

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  • Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation
    Aranda Aragón, Sergio; Alcaine Colet, Anna, 1992-; Blanco, Enrique; Borràs, Eva; Caillot, Claire; Sabidó Aguadé, Eduard, 1981-; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2019)
    Profiling the chromatin-bound proteome (chromatome) in a simple, direct, and reliable manner might be key to uncovering the role of yet uncharacterized chromatin factors in physiology and disease. Here, we have designed ...
  • Chromatin-bound proteome profiling by genome capture
    Aranda Aragón, Sergio; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Di Croce, Luciano (Elsevier, 2020)
    De novo identification of chromatin interactors can reveal unexpected pathways relevant to physiology and human disease. Inspired by the DNA mediated chromatin pull-down (Dm-ChP) technology (also known as iPOND [isolation ...
  • Functional and pathological roles of AHCY
    Vizán, Pedro; Di Croce, Luciano; Aranda Aragón, Sergio (Frontiers Media, 2021)
    Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of ...
  • GATA2 promotes hematopoietic development and represses cardiac differentiation of human mesoderm
    Castaño, Julio; Aranda Aragón, Sergio; Blanco, Enrique; Mereu, Elisabetta; Heyn, Holger; Di Croce, Luciano; Giorgetti, Alessandra (Elsevier, 2019)
    In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement ...
  • Identification and characterization of the molecular pathways regulating the cell cycle-linked pluripotency exit
    Alcaine Colet, Anna (Universitat Pompeu Fabra, 2019-12-02)
    The self-renewing nature of embryonic stem cells (ESCs) is a consequence of their ability to proliferate while maintaining pluripotency, by means the capacity to differentiate into all adult cell types. Despite the remarkable ...
  • New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress
    Ercilla, Amaia; Llopis, Alba; Feu, Sonia; Aranda Aragón, Sergio; Ernfors, Patrik; Freire, Raimundo; Agell, Neus (Oxford University Press, 2016)
    Defects in DNA replication and repair are known to promote genomic instability, a hallmark of cancer cells. Thus, eukaryotic cells have developed complex mechanisms to ensure accurate duplication of their genomes. While ...
  • Polycomb factor PHF19 controls cell growth and differentiation toward erythroid pathway in chronic myeloid leukemia cells
    García Montolío, Marc, 1991-; Ballaré, Cecilia Julia; Blanco, Enrique; Gutiérrez, Arantxa; Aranda Aragón, Sergio; Gómez, Antonio; Kok, Chung H.; Yeung, David T.; Hughes, Timothy P.; Vizán, Pedro; Di Croce, Luciano (Frontiers Media, 2021)
    Polycomb group (PcG) of proteins are a group of highly conserved epigenetic regulators involved in many biological functions, such as embryonic development, cell proliferation, and adult stem cell determination. PHD finger ...
  • Polycomb repressive complex 2 deregulation in tissue homeostasis and cancer
    Espejo Díaz, María Isabel (Universitat Pompeu Fabra, 2023-09-29)
    Polycomb group (PcG) proteins are transcriptional repressors that control development and cell fate. Polycomb Repressive Complex 2 (PRC2) misfunction has been recurrently associated with embryonic lethality and disease, ...
  • PRC2 shields the potency of human stem cells
    Aranda Aragón, Sergio; Condemi, Livia; Di Croce, Luciano (Nature Research, 2022)
  • Regulation of gene transcription by Polycomb proteins
    Aranda Aragón, Sergio; Mas, Glòria; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2015)
    The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic ...
  • SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state
    Sebastián Pérez, Rubén; Nakagawa, Shoma; Tu, Xiaochuan; Aranda Aragón, Sergio; Pesaresi, Martina; Gómez García, Pablo; Alcoverro-Bertran, Marc; Gómez Vázquez, José Luis; Carnevali, Davide; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Martin, Laura; Nissim Rafinia, Malka; Meshorer, Eran; Neguembor, Maria Victoria; Di Croce, Luciano; Cosma, Maria Pia (eLife, 2023)
    Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C heterochromatin ...
  • SpikChIP: a novel computational methodology to compare multiple ChIP-seq using spike-in chromatin
    Blanco, Enrique; Di Croce, Luciano; Aranda Aragón, Sergio (Oxford University Press, 2021)
    In order to evaluate cell- and disease-specific changes in the interacting strength of chromatin targets, ChIP-seq signal across multiple conditions must undergo robust normalization. However, this is not possible using ...
  • The bivalent genome: characterization, structure, and regulation
    Blanco, Enrique; González Ramírez, Mar, 1991-; Alcaine Colet, Anna, 1992-; Aranda Aragón, Sergio; Di Croce, Luciano (Elsevier, 2020)
    An intricate molecular machinery is at the core of gene expression regulation in every cell. During the initial stages of organismal development, the coordinated activation of diverse transcriptional programs is crucial ...
  • The changing chromatome as a driver of disease: a panoramic view from different methodologies
    Espejo, Isabel; Di Croce, Luciano; Aranda Aragón, Sergio (Wiley-VCH Verlag, 2020)
    Chromatin-bound proteins underlie several fundamental cellular functions, such as control of gene expression and the faithful transmission of genetic and epigenetic information. Components of the chromatin proteome (the ...

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