Browsing by Author "Ampurdanés, Coral"

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  • Pérez-Peiró, Maria; Valentí-Serra, Paula; León-González, Blanca; Ampurdanés, Coral; Duran, Xavier; Yélamos, José; Barreiro Portela, Esther (MDPI, 2023)
    In cancer, overactivation of poly (ADPribose) polymerases (PARP) plays a relevant role in DNA repair. We hypothesized that treatment with the PARP inhibitor rucaparib may reduce tumor burden via several biological mechanisms ...
  • Tang, Jun; Curull Serrano, Víctor; Wang, Xuejie; Ampurdanés, Coral; Duran, Xavier; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Yélamos López, José; Barreiro Portela, Esther (MDPI, 2020)
    Background: Lung cancer (LC) is a major leading cause of death worldwide. Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 are key players in cancer. We aimed to assess PARP-1 and PARP-2 expression and activity and DNA ...
  • Navarro, Judith; Gozalbo-López, Beatriz; Méndez, Andrea C.; Dantzer, Françoise; Schreiber, Valérie; Martínez, Carlos; Arana, David M.; Farrés, Jordi; Revilla-Nuin, Beatriz; Bueno, María F.; Ampurdanés, Coral; Galindo-Campos, Miguel A.; Knobel, Philip A.; Segura-Bayona, Sandra; Martín Caballero, Juan; Stracker, Travis; Aparicio, Pedro; Del Val, Margarita; Yélamos López, José (Nature Publishing Group, 2017)
    The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing ...

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