Browsing by Author "Aloia, Luigi"

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  • Direct interaction between Id1 and Zrf1 controls neural differentiation of embryonic stem cells
    Aloia, Luigi; Gutiérrez, Arantxa; Martín Caballero, Juan; Di Croce, Luciano (Wiley-Blackwell, 2015)
    Id proteins are dominant-negative regulators within the HLH family of proteins. In embryonic stem cells (ESCs), Id1 and Id3 maintain the pluripotent state by preventing neural differentiation. The Id1-interacting protein ...
  • Polycomb regulates mesoderm cell fate-specification in embryonic stem cells through activation and repression mechanisms
    Morey Ramonell, Lluís; Santanach Buxaderas, Alexandra, 1988-; Blanco, Enrique; Aloia, Luigi; Nora, Elphège P.; Bruneau, Benoit G.; Di Croce, Luciano (Elsevier, 2015)
    Polycomb complexes (PRC1 and PRC2) are essential regulators of epigenetic gene silencing in embryonic and adult stem cells. Emerging evidence suggests that the core subunit composition regulates distinct biological processes, ...
  • RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells
    Morey Ramonell, Lluís; Aloia, Luigi; Cozzuto, Luca; Aznar Benitah, Salvador; Di Croce, Luciano (Elsevier, 2013)
    The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate. In mouse embryonic stem cells (ESCs), two major variations of PRC1 complex, defined by the mutually exclusive presence of Cbx7 or RYBP, ...
  • Zrf1 is required to establish and maintain neural progenitor identity
    Aloia, Luigi; Di Stefano, Bruno, 1984-; Sessa, Alessandro; Morey, Lluis; Santanach, Alexandra; Gutierrez, Arantxa; Cozzuto, Luca; Aznar Benitah, Salvador; Graf, T. (Thomas); Broccoli, Vania; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2014)
    The molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs) are largely unknown. Recently, we reported that the Zuotin-related factor 1 (Zrf1) is ...
  • ZRF1: a novel epigenetic regulator of stem cell identity and cancer
    Aloia, Luigi; Demajo Meseguer, Santiago, 1985-; Di Croce, Luciano (Taylor & Francis (Routledge), 2015)
    The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma cells, ZRF1 promotes transcriptional ...

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