Browsing by Author "Aligué, Rosa"

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  • A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase
    Marquina, Maribel; Lambea, Eva; Carmona, Mercè; Sánchez-Marinas, Marta; López-Aviles, Sandra; Ayté del Olmo, José; Hidalgo Hernando, Elena; Aligué, Rosa (Nature Research, 2022)
    The fission yeast mitogen-activated kinase (MAPK) Sty1 is essential for cell survival in response to different environmental insults. In unstimulated cells, Sty1 forms an inactive ternary cytoplasmatic complex with the ...
  • p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes
    Perearnau, Anna; Orlando, Serena; Islam, Abul, 1978-; Gallastegui Calvache, Edurne; Martínez, Jonatan; Jordan Vallès, Albert; Bigas Salvans, Anna; Aligué, Rosa; Pujol, Maria Jesús; Bachs Valldeneu, Oriol (Oxford University Press, 2017)
    The cyclin-dependent kinase inhibitor p27Kip1 (p27) also behaves as a transcriptional repressor. Data showing that the p300/CBP-associated factor (PCAF) acetylates p27 inducing its degradation suggested that PCAF and p27 ...
  • Role of p27Kip1 as a transcriptional regulator
    Bachs Valldeneu, Oriol; Gallastegui Calvache, Edurne; Orlando, Serena; Bigas Salvans, Anna; Morante-Redolat, José Manuel; Serratosa, Joan; Fariñas, Isabel; Aligué, Rosa; Pujol, Maria Jesús (Impact Journal, 2018)
    The protein p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region into the catalytic cleave ...
  • β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.
    Gekas, Christos; Teresa, D'Altri 1984-; Aligué, Rosa; González, Jessica; Espinosa Blay, Lluís; Bigas Salvans, Anna (Nature Publishing Group, 2016)
    Notch activation is instrumental in the development of most T-cell acute lymphoblastic leukemia (T-ALL) cases, yet Notch mutations alone are not sufficient to recapitulate the full human disease in animal models. We here ...

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