Browsing by Author "Alfano, Rossella"

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  • A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism
    Alfano, Rossella; Kogevinas, Manolis; Sunyer Deu, Jordi; Vrijheid, Martine; Plusquin, Michelle (Elsevier, 2020)
    Background: Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains ...
  • Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
    Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante Pineda, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; Kok, Theo M. de; Nawrot, Tim S.; Relton, Caroline L.; Robinson, Oliver; Roumeliotaki, Theano; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Plusquin, Michelle (BioMed Central, 2023)
    Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • Genetic regulation of newborn telomere length is mediated and modified by DNA methylation
    Wang, Congrong; Alfano, Rossella; Reimann, Brigitte; Hogervorst, Janneke; Bustamante Pineda, Mariona; De Vivo, Immaculata; Plusquin, Michelle; Nawrot, Tim S.; Martens, Dries S. (Frontiers, 2022)
    Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed. In addition, ...
  • Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
    Sharp, Gemma C.; Alfano, Rossella; Ghantous, Akram; Urquiza, José M.; Rifas-Shiman, Sheryl L.; Page, Christian M.; Jin, Jianping; Fernández-Barrés, Sílvia; Santorelli, Gillian; Tindula, Gwen; Pregnancy and Childhood Epigenetics (PACE) consortium (Oxford University Press, 2021)
    Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this ...

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