Browsing by Author "Alexopoulos, Leonidas G."

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  • Dynamics and heterogeneity of brain damage in multiple sclerosis
    Kotelnikova, Ekaterina; Kiani, Narsis A.; Abad Adan, Elena; Martínez Lapiscina, Elena H.; Andorrà, Magí; Zubizarreta, Irati; Pulido Valdeolivas, Irene; Pertsovskaya, Inna; Alexopoulos, Leonidas G.; Olsson, Tomas; Martin, Roland; Paul, Friedemann; Tegnér, Jesper; García Ojalvo, Jordi; Villoslada, Pablo (Public Library of Science (PLoS), 2017)
    Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is not well understood how these events interact and evolve to evoke ...
  • Immuno-modulatory effects of intervertebral disc cells
    Bermúdez-Lekerika, Paola; Crump, Katherine B.; Tseranidou, Sofia; Nüesch, Andrea; Kanelis, Exarchos; Alminnawi, Ahmad; Baumgartner, Laura; Muñoz-Moya, Estefano; Compte, Roger; Gualdi, Francesco; Alexopoulos, Leonidas G.; Geris, Liesbet; Wuertz-Kozak, Karin; Le Maitre, Christine L.; Noailly, Jérôme; Gantenbein, Benjamin (Frontiers, 2022)
    Low back pain is a highly prevalent, chronic, and costly medical condition predominantly triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and biochemical changes in intervertebral discs ...
  • Multiscale regulation of the intervertebral disc: achievements in experimental, in silico, and regenerative research
    Baumgartner, Laura; Wuertz-Kozak, Karin; Le Maitre, Christine L.; Wignall, Francis; Richardson, Stephen M.; Hoyland, Judith; Ruiz Wills, Carlos; González Ballester, Miguel Ángel, 1973-; Neidlin, Michael; Alexopoulos, Leonidas G.; Noailly, Jérôme (MDPI, 2021)
    Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options ...
  • Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments
    Segarra-Queralt, Maria; Neidlin, Michael; Tió, Laura; Monfort, Jordi; Monllau García, Juan Carlos; González Ballester, Miguel Ángel, 1973-; Alexopoulos, Leonidas G.; Piella Fenoy, Gemma; Noailly, Jérôme (Nature Research, 2022)
    In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic activity, which leads to cartilage degradation. To enable the semiquantitative interpretation of the intricate mechanisms of OA ...

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