Browsing by Author "Alemany, Silvia"

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  • A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children.
    Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Bustamante Pineda, Mariona; Pujol Martí, Jesús, 1981-; Macià, Dídac; Martínez-Vilavella, Gerard; Fenoll, Raquel; Álvarez Pedrerol, Mar; Forns i Guzman, Joan, 1981-; Júlvez Calvo, Jordi; Suades González, Elisabet; Llop, Sabrina; Rebagliato, Marisa; Sunyer Deu, Jordi (Public Library of Science (PLoS) , 2016)
    BACKGROUND: Attention function filters and selects behaviorally relevant information. This capacity is impaired in some psychiatric disorders and has been proposed as an endophenotype for Attention-Deficit/Hyperactivity ...
  • A genome-wide association study of total child psychiatric problems scores
    Neumann, Alexander; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Sunyer Deu, Jordi; Tiemeier, Henning (Public Library of Science (PLoS), 2022)
    Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in ...
  • A genome-wide association study of total child psychiatric problems scores
    Neumann, Alexander; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Sunyer Deu, Jordi; Tiemeier, Henning (Public Library of Science (PLoS), 2022)
    Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in ...
  • Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents
    Essers, Esmée; Binter, Anne-Claire; Neumann, Alexander; White, Tonya; Alemany, Silvia; Guxens Junyent, Mònica (Elsevier, 2023)
    Background: Air pollution exposure is associated with impaired neurodevelopment, altered structural brain morphology in children, and neurodegenerative disorders. Differential susceptibility to air pollution may be influenced ...
  • Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
    Neumann, Alexander; Alemany, Silvia; González, Juan Ramón; Julvez, Jordi; Maitre, Léa; Sunyer Deu, Jordi; Guxens Junyent, Mònica; Tiemeier, Henning (Nature Research, 2020)
    Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is ...
  • Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals
    Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Milà Alomà, Marta; Suárez-Calvet, Marc; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Grau-Rivera, Oriol; Minguillón, Carolina; Fauria, Karine; Domingo Gispert, Juan; Gascon Merlos, Mireia, 1984-; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; ALFA Study (Elsevier, 2021)
    Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and ...
  • DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication
    Serdarevic, Fadila; Luo, Mannan; Karabegović, Irma; Binter, Anne-Claire; Alemany, Silvia; Mutzel, Ryan; Guxens Junyent, Mònica; Bustamante Pineda, Mariona; Hajdarpasic, Aida; White, Tonya; Felix, Janine Frédérique; Cecil, Charlotte A. M.; Tiemeier, Henning (Taylor & Francis, 2023)
    Lower fine motor performance in childhood has been associated with poorer cognitive development and neurodevelopmental conditions such as autism spectrum disorder, yet, biological underpinnings remain unclear. DNA methylation ...
  • DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
    van Dongen, Jenny; Alemany, Silvia; González Ruiz, Juan Ramón; Sunyer Deu, Jordi; Vrijheid, Martine; Boomsma, Dorret I. (Nature Research, 2021)
    DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of ...
  • Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children
    Mortamais, Marion; Pujol Martí, Jesús, 1981-; Martínez-Vilavella, Gerard; Fenoll, Raquel; Reynes, Christelle; Sabatier, Robert; Rivas, Ioar; Forns i Guzman, Joan, 1981-; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cirach, Marta; Alvarez, Mar; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi (Elsevier, 2019)
    Objective: Air pollution (AP) may affect neurodevelopment, but studies about the effects of AP on the growing human brain are still scarce. We aimed to investigate the effects of prenatal exposure to AP on lateral ventricles ...
  • Genetic association study of childhood aggression across raters, instruments, and age
    Ip, Hill F.; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Sunyer Deu, Jordi; Boomsma, Dorret I. (Nature Research, 2021)
    Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...
  • Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms
    Jami, Eshim S.; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Sunyer Deu, Jordi; Middeldorp, Christel M. (Elsevier, 2022)
    Objective: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated ...
  • Independent multiple factor association analysis for multiblock data in imaging genetics
    Vilor Tejedor, Natàlia, 1988-; Ikram, Mohammad Arfan; Roshchupkin, Gennady V.; Cáceres, Alejandro; Alemany, Silvia; Vernooij, Meike W.; Niessen, Wiro J.; Duijn, Cornelia M. van; Sunyer Deu, Jordi; Adams, Hieab H.; González Ruiz, Juan Ramón (Springer, 2019)
    Multivariate methods have the potential to better capture complex relationships that may exist between different biological levels. Multiple Factor Analysis (MFA) is one of the most popular methods to obtain factor scores ...
  • Interaction between airborne copper exposure and ATP7B polymorphisms on inattentiveness in scholar children
    Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Bustamante Pineda, Mariona; Álvarez Pedrerol, Mar, 1981-; Rivas, Ioar; Forns i Guzman, Joan, 1981-; Querol, Xavier; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi (Elsevier, 2017)
    Recent research indicates that airborne copper exposure in scholar children negatively affects brain functioning. These effects are likely to be influenced by the efficiency of copper metabolism, which is partly regulated ...
  • Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
    Caramaschi, Doretta; Alemany, Silvia; Sunyer Deu, Jordi; Sharp, Gemma C. (Nature Research, 2022)
    Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population ...
  • Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children
    Aguilar Lacasaña, Sofía; Vilor Tejedor, Natàlia, 1988-; Jansen, Philip R.; López Vicente, Mònica, 1988-; Bustamante Pineda, Mariona; Burgaleta Díaz, Miguel, 1981-; Sunyer Deu, Jordi; Alemany, Silvia (Cambridge University Press, 2020)
    Background: Attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are child-onset neurodevelopmental disorders frequently accompanied by cognitive difficulties. In the current study, we aim ...
  • Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts
    Alemany, Silvia; Avella García, Claudia B., 1982-; García Esteban, Raquel; Casas Sanahuja, Maribel; Júlvez Calvo, Jordi; Sunyer Deu, Jordi (Springer, 2021)
    The potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative ...
  • Strategies for integrated analysis in imaging genetics studies
    Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cáceres, Alejandro; Bustamante Pineda, Mariona; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi; González Ruiz, Juan Ramón (Elsevier, 2018)
    Imaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the ...
  • Traffic-related air pollution, APOEε4 status, and neurodevelopmental outcomes among school children enrolled in the BREATHE project (Catalonia, Spain)
    Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; García Esteban, Raquel; Bustamante Pineda, Mariona; Dadvand, Payam; Esnaola, Mikel; Mortamais, Marion; Forns i Guzman, Joan, 1981-; van Drooge, Barend L.; Álvarez Pedrerol, Mar; Grimalt Obrador, Joan; Rivas, Ioar; Querol, Xavier; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi (National Institute of Environmental Health Sciences (NIEHS), 2018)
    BACKGROUND: Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of ...

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