Browsing by Author "Alcalde, Miguel Angel"

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  • Genetic approaches in improving biotechnological production of taxanes: An update
    Pérez Matas, Edgar; Hidalgo Martínez, Diego; Escrich Montañana, Ainoa; Alcalde, Miguel Angel; Moyano Claramunt, Elisabet; Bonfill Baldrich, Ma. Mercedes; Palazón Barandela, Javier (Frontiers, 2023)
    Paclitaxel (PTX) and its derivatives are diterpene alkaloids widely used as chemotherapeutic agents in the treatment of various types of cancer. Due to the scarcity of PTX in nature, its production in cell cultures and ...
  • Metabolic gene expression and centelloside production in elicited Centella asiatica hairy root cultures
    Alcalde, Miguel Angel; Cusidó Vidal, Rosa M.; Moyano Claramunt, Elisabet; Palazón Barandela, Javier; Bonfill Baldrich, Ma. Mercedes (Elsevier, 2022)
    The most economically important centellosides, madecassoside and asiaticoside, are produced in very low amounts in Centella asiatica (L.) Urban roots. With the aim of overcoming this limitation, in this work we compared ...
  • Selective Synthesis of the Human Drug Metabolite 5′-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase
    Gomez de Santos, Patricia; Cañellas, Marina; Tieves, Florian; Younes, Sabry H. H.; Molina-Espeja, Patricia; Hofrichter, Martin; Hollmann, Frank; Guallar i Tasies, Víctor; Alcalde, Miguel Angel (American Chemical Society (ACS), 2018)
    Propranolol is a widely used beta-blocker that is metabolized by human liver P450 monooxygenases into equipotent hydroxylated human drug metabolites (HDMs). It is paramount for the pharmaceutical industry to evaluate the ...

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