Browsing by Author "Agustí, Alvar"

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  • Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial
    Agustí, Alvar; Pascual Guàrdia, Sergi, 1979-; Faner, Rosa (European Respiratory Society, 2022)
  • Ausencia de correlación entre marcadores de inflamación pulmonar y sistémica en pacientes con enfermedad pulmonar obstructiva crónica: un análisis bi-compartimental simultáneo
    Núñez, Belén; Sauleda Roig, Jaume; García Aymerich, Judith; Noguera, Aina; Monsó, Eduard; Gómez, Federico P.; Barreiro Portela, Esther; Marin, Alicia; Antó i Boqué, Josep Maria; Agustí, Alvar; Caracterización Fenotípica y Evolución de la EPOC (PAC-COPD) (Elsevier, 2016)
    INTRODUCTION: The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators ...
  • Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
    Balcells Vilarnau, Eva, 1967-; Gimeno Santos, Elena, 1980-; De Batlle, Jordi; Ramon, Maria Antonia; Rodríguez, Esther; Benet, Marta; Ferrer, Jaume; Farrero, Eva; Ferrer, Antoni-Lluc, 1942-; Guerra, Stefano; Ferrer, Jaume; Sauleda Roig, Jaume; Barberà, Joan Albert; Agustí, Alvar; Rodriguez, Robert, 1968-; Gea Guiral, Joaquim; Antó i Boqué, Josep Maria; García Aymerich, Judith (BioMed Central, 2015)
    Background. Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD./nMethods. The PAC-COPD cohort included 342 COPD ...
  • Characteristics of patients admitted for the first time for COPD exacerbation
    Balcells Vilarnau, Eva, 1967-; Antó i Boqué, Josep Maria; Gea Guiral, Joaquim; Gómez, Federico P.; Rodríguez, Esther; Marin, Alicia; Ferrer, Antoni-Lluc, 1942-; De Batlle, Jordi; Farrero, Eva; Benet, Marta; Orozco Levi, Mauricio; Ferrer, Jaume; Agustí, Alvar; Gáldiz, Juan B.; Belda, José; García Aymerich, Judith (Elsevier, 2009)
    BACKGROUND: This study describes the characteristics of a large sample of patients hospitalised for the first time for a chronic obstructive pulmonary disease (COPD) exacerbation. METHODS: All subjects first admitted for ...
  • Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
    Roca, Josep; Vargas, Claudia; Cano, Isaac; Selivanov, Vitaly; Barreiro Portela, Esther; Maier, Dieter; Falciani, Francesco; Wagner, Peter; Cascante Serratosa, Marta; García Aymerich, Judith; Kalko, Susana G.; Marin de Mas, Igor; Tegnér, Jesper; Escarrabill, Joan; Agustí, Alvar; Gomez Cabrero, David; Synergy-COPD consortium (BioMed Central, 2014)
    Background and hypothesis: Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and ...
  • Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD
    Ramon, Maria Antonia; Ferrer, Jaume; Gimeno Santos, Elena, 1980-; Donaire González, David; Rodríguez, Esther; Balcells Vilarnau, Eva, 1967-; De Batlle, Jordi; Benet, Marta; Guerra, Stefano; Sauleda Roig, Jaume; Ferrer, Antoni-Lluc, 1942-; Farrero, Eva; Gea Guiral, Joaquim; Barberà, Joan Albert; Agustí, Alvar; Rodríguez Roisin, Robert; Antó i Boqué, Josep Maria; García Aymerich, Judith; PAC-COPD Study Group (Wiley, 2016)
    BACKGROUND AND OBJECTIVE: Exercise capacity decline is a predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Static pulmonary hyperinflation is a key determinant of exercise performance, ...
  • Network medicine analysis of COPD multimorbidities
    Grosdidier, Solène; Ferrer, Antoni-Lluc, 1942-; Faner, Rosa; Piñero González, Janet, 1977-; Roca, Josep; García Cosio, Borja; Agustí, Alvar; Gea Guiral, Joaquim; Sanz, Ferran; Furlong, Laura I., 1971- (BioMed Central, 2014)
    Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer concomitant disorders that worsen significantly their health status and vital prognosis. The pathogenic mechanisms underlying COPD ...
  • Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients
    Millares, Laura; Pascual Guàrdia, Sergi, 1979-; Montón, Concepción; García-Nuñez, Marian; Lalmolda, Cristina; Faner, Rosa; Casadevall Fusté, Carme; Setó, Laia; Capilla, Silvia; Moreno, Amàlia; Castro-Acosta, Ady Angélica; Alvarez-Martinez, Carlos José; Sibila, Oriol; Peces-Barba, Germán; Cosio, Borja G.; Agustí, Alvar; Gea Guiral, Joaquim; Monsó, Eduard (BioMed Central, 2019)
    Background: The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating ...
  • Telomere length but not mitochondrial DNA copy number is altered in both young and old COPD
    Casas-Recasens, Sandra; Mendoza, Nuria; López-Giraldo, Alejandra; Garcia, Tamara; Cosio, Borja G.; Pascual Guàrdia, Sergi, 1979-; Acosta-Castro, Ady; Borrás Santos, Alícia, 1974-; Gea Guiral, Joaquim; Garrabou, Glòria; Agustí, Alvar; Faner, Rosa (Frontiers, 2021)
    Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise ...
  • The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model
    Ramon, Maria Antonia; Ter Riet, Gerben; Carsin, Anne-Elie; Gimeno Santos, Elena, 1980-; Agustí, Alvar; Antó i Boqué, Josep Maria; Donaire González, David; Ferrer, Jaume; Rodríguez, Esther; Rodríguez Roisin, Robert; Puhan, Milo A.; García Aymerich, Judith (European Respiratory Society, 2018)
    The vicious circle of dyspnoea-inactivity has been proposed, but never validated empirically, to explain the clinical course of chronic obstructive pulmonary disease (COPD). We aimed to develop and validate externally a ...
  • The EASI model: A first integrative computational approximation to the natural history of COPD
    Agustí, Alvar; Compte, Albert; Faner, Rosa; García Aymerich, Judith; Noell, Guillaume; García Cosio, Borja; Rodríguez Roisin, Robert; Celli, Bartolomé R.; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2017)
    The natural history of chronic obstructive pulmonary disease (COPD) is still not well understood. Traditionally believed to be a self-inflicted disease by smoking, now we know that not all smokers develop COPD, that other ...
  • Validity of prognostic models of critical COVID-19 is variable. A systematic review with external validation
    Cárdenas Fuentes, Gabriela, 1985-; Bosch de Basea i Gómez, Magda, 1982-; Cobo, Inés; Subirana Cachinero, Isaac; Ceresa, Mario; Famada, Ernest; Gimeno Santos, Elena, 1980-; Delgado Ortiz, Laura; Faner, Rosa; Molina-Molina, María; Agustí, Alvar; Muñoz, Xavier; Sibila, Oriol; Gea Guiral, Joaquim; García Aymerich, Judith (Elsevier, 2023)
    Objectives: To identify prognostic models which estimate the risk of critical COVID-19 in hospitalized patients and to assess their validation properties. Study design and setting: We conducted a systematic review in Medline ...