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  • Talluri, Kalyan T.; Martínez de Albéniz, Víctor (2010-02-01)
  • Invergo, Brandon M., 1982-; Montanucci, Ludovica, 1978-; Bertranpetit, Jaume, 1952- (Royal Society, 2015)
    Determining the influence of complex, molecular-system dynamics on the evolution of proteins is hindered by the significant challenge of quantifying the control exerted by the proteins on system output. We have employed a ...
  • Martí Solano, Maria; Sanz, Ferran; Pastor Maeso, Manuel; Selent, Jana (Public Library of Science (PLoS), 2014)
    Functional selectivity is a property of G protein-coupled receptors that allows them to preferentially couple to particular signaling partners upon binding of biased agonists. Publication of the X-ray crystal structure of ...
  • Galera Laporta, Letícia, 1985- (Universitat Pompeu Fabra, 2019-02-08)
    Bacterial proliferation has been studied for more than 100 years, but our knowledge of the mechanisms that control its dynamical aspects is still very limited. In this Thesis we have studied, at both singlecell and population ...
  • Sen, Shaunak; García Ojalvo, Jordi; Elowitz, Michael B. (Public Library of Science (PLoS), 2011)
    Under conditions of nutrient limitation, Bacillus subtilis cells terminally differentiate into a dormant spore state. Progression to sporulation is controlled by a genetic circuit consisting of a phosphorelay embedded in ...
  • Schulze, Aljoscha, 1980-; Gómez Marín, Alex; Rajendran, Vani G.; Lott, Gus; Musy, Marco; Ahammad, Parvez; Deogade, Ajinkya; Sharpe, James; Riedl, Julia, 1981-; Jarriault, David; Trautman, Eric T.; Werner, Christopher; Venkadesan, Madhusudhan; Druckmann, Shaul; Jayaraman, Vivek; Louis, Matthieu (eLife, 2015)
    Behavioral strategies employed for chemotaxis have been described across phyla, but the sensorimotor basis of this phenomenon has seldom been studied in naturalistic contexts. Here, we examine how signals experienced during ...
  • Gabaldà Sagarra, Marçal,1988- (Universitat Pompeu Fabra, 2017-01-23)
    Living beings strive to survive and reproduce. To do so they need to monitor and adapt to a dynamic environment, taking advantage of the opportunities and dodging the threats that they may encounter. This thesis is devoted ...
  • Kotelnikova, Ekaterina; Kiani, Narsis A.; Abad Adan, Elena; Martínez Lapiscina, Elena H.; Andorra, Magi; Zubizarreta, Irati; Pulido Valdeolivas, Irene; Pertsovskaya, Inna; Alexopoulos, Leonidas G.; Olsson, Tomas; Martin, Roland; Paul, Friedemann; Tegnér, Jesper; García Ojalvo, Jordi; Villoslada, Pablo (Public Library of Science (PLoS), 2017)
    Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is not well understood how these events interact and evolve to evoke ...
  • Ewijk, Anne R. van (Centre d'Informació i Documentació Internacionals a Barcelona (CIDOB)Grup de Recerca Interdisciplinari sobre Immigració (GRITIM-UPF), 2011)
    This chapter offers a case-study of diversity and diversity policies within/nthe Mossos d’Esquadra, the police force of the Catalan autonomous community/nin Spain. The case is described in a comprehensive way (including/npolicies ...
  • Hernando Herráez, Irene, 1985-; Prado Martínez, Javier, 1987-; Garg, Paras; Fernández Callejo, Marcos; Heyn, Holger; Hvilsom, Christina; Navarro i Cuartiellas, Arcadi, 1969-; Esteller, Manel; Sharp, Andrew J.; Marquès i Bonet, Tomàs, 1975- (Public Library of Science (PLoS), 2013)
    DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, ...
  • Jiménez, Alba; Cotterell, James; Munteanu, Andreea; Sharpe, James (Cold Spring Harbor Laboratory Press, 2015)
    To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression ...
  • Kaltenbrunner, Andreas (Universitat Pompeu Fabra, 2008-03-07)
    Esta tesis estudia dos diferentes dinámicas de intercambio de mensajes entre unidades estocásticas.<br/>Primero, analizamos un conjunto de neuronas estocásticas tipo integración - y - disparo con integración sin pérdidas, ...
  • Font Mateu, Jofre, 1977- (Universitat Pompeu Fabra, 2016-12-05)
    El receptor de la progesterona és un regulador clau per la proliferació de les cèl·lules de càncer de mama dependents d’hormona. El mecanisme d’acció del PR ha tingut un paper important en la resolució del mecanisme molecular ...
  • Obućina, Ognjen (Universitat Pompeu Fabra, 2012-07-16)
    The broad objective of this thesis is to study the patterns of objective and subjective well-being among the immigrants in Europe. The main part of the thesis consists of three single-authored empirical chapters. The first ...
  • Sardanyés i Cayuela, Josep (Universitat Pompeu Fabra, 2009-05-06)
    En aquesta tesi he investigat diversos camps de la biologia que podrien englobar-se en la disciplina general dels sistemes no lineals de replicadors. Els treballs presentats en aquesta tesis investiguen diversos fenomens ...
  • Boni, Jacopo, 1987- (Universitat Pompeu Fabra, 2019-06-20)
    DYRK (dual-specificity tyrosine-regulated kinases) is an evolutionary conserved family of protein kinases involved in the regulation of cellular processes, such as proliferation and survival, which play pivotal role in ...
  • Rozen, Esteban J.; Roewenstrunk, Julia Maria, 1981-; Barallobre, María José; Di Vona, Chiara, 1981-; Jung, Carole; Figueiredo, Ana F.; Luna, Jeroni; Fillat i Fonts, Cristina; Arbonés de Rafael, Maria Lourdes, 1959-; Graupera, Mariona; Valverde, M. A. (Miguel Ángel), 1963-; Luna Gargantilla, Susana de la (Elsevier, 2018)
    Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells ...
  • Grau, Cristina; Arató, Krisztina, 1981-; Fernández-Fernández, José Manuel, 1967-; Valderrama, Aitana; Sindreu, Carlos; Fillat i Fonts, Cristina; Ferrer, Isidre; Luna, Susana de la; Altafaj, Xavier (Frontiers, 2014)
    N-methyl-D-aspartate glutamate receptors (NMDARs) play a pivotal role in neural development and synaptic plasticity, as well as in neurological disease. Since NMDARs exert their function at the cell surface, their density ...
  • Rauschenberger, Maria (ACM Association for Computer Machinery, 2016)
    The aim of this research is to show that a playful approach combined with music can detect children with dyslexia. Early detection will prevent children from suffering in school until they are detected due to bad grades. ...
  • Rello, Luz (Universitat Pompeu Fabra, 2014-06-27)
    Worldwide, 10% of the population has dyslexia, a cognitive disability that reduces readability and comprehension of written information. The goal of this thesis is to make text more accessible for people with dyslexia by ...