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  • Ruiz-Arenas, Carlos; Hernandez-Ferrer, Carles, 1987-; Vives Usano, Marta, 1990-; Marí, Sergi; Casas Sanahuja, Maribel; Vafeiadi, Marina, 1983-; Vrijheid, Martine; González Ruiz, Juan Ramón; Bustamante Pineda, Mariona (eLife Sciences Publications, 2022)
    Background: The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA methylation levels and gene expression, might help the biological interpretation of epigenome-wide ...
  • Defaus, Sira; Avilés, Manuel; Andreu Martínez, David; Gutiérrez Gallego, Ricardo, 1968- (Elsevier, 2016)
    Glycan-protein interactions play a key role in mammalian fertilization, but data on the composition and identities of protein complexes involved in fertilization events are scarce, with the added complication that the ...
  • Islam, Abul, 1978-; Guiu Sagarra, Jordi, 1983-; Bergen, Dylan J.M.; de Pater, Emma; Ayllon, Verónica; Gama-Norton, Leonor; Ruiz Herguido, Cristina; González, Jessica; López Bigas, Núria; Menéndez, Pablo; Dzierzak, Elaine; Espinosa Blay, Lluís; Bigas Salvans, Anna (Rockefeller University Press, 2014)
    Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify ...
  • Galan Martínez, Silvia, 1992-; Serra, François; Marti-Renom, Marc A. (Oxford University Press, 2022)
    Genome-wide profiling of long-range interactions has revealed that the CCCTC-Binding factor (CTCF) often anchors chromatin loops and is enriched at boundaries of the so-called Topologically Associating Domains, which ...
  • Aterido Ballonga, Adrià (Universitat Pompeu Fabra, 2019-03-22)
    Rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus, Crohn’s disease and ulcerative colitis are six of the most prevalent immune-mediated inflammatory diseases (IMIDs) and are associated with ...
  • Sheang, Kim Cheng; Koptient, Anaïs; Grabar, Natalia; Saggion, Horacio (ATALA, 2022)
    L’objectif de la simplification automatique des textes consiste à fournir une nouvelle version de documents qui devient plus facile à comprendre pour une population donnée ou plus facile à traiter par d’autres applications ...
  • Kuderna, Lukas, 1989-; Valenzuela, Alejandro; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Kai-How Farh, Kyle (Nature Research, 2023)
    Noncoding DNA is central to our understanding of human gene regulation and complex diseases1,2, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in ...
  • Rojano i Luque, Xavier; Blancafort-Alias, Sergi; Prat Casanovas, Susanna; Forné, Susanna; Martín Vergara, Nuria; Fabregat Povill, Pilar; Vila Royo, Maria; Serrano, Rosa; Sánchez-Rodríguez, Dolores; Vílchez Saldaña, Montserrat; Martínez, Iris; Domínguez López, Mariola; Riba Porquet, Francesc; Intxaurrondo González, Aimar; Salvà Casanovas, Antoni (BioMed Central, 2023)
    The World Health Organization (WHO) has developed the Integrated Care for Older People (ICOPE) strategy to face the challenges of ageing societies. This strategy is focused on person centered care and the assessment intrinsic ...
  • Segura Tigell, Sonia; Gadea, Alejandra; Nonell Mazelón, Lara; Andrades, Evelyn; Sánchez, Silvia; Pujol Vallverdú, Ramon Maria; Hernández Muñoz, María Inmaculada; Toll Abelló, Agustín (Public Library of Science (PLoS), 2020)
    Actinic keratosis is a common skin disease that may progress to invasive squamous cell carcinoma if left untreated. Ingenol mebutate has demonstrated efficacy in field treatment of actinic keratosis. However, molecular ...
  • Besso, María José; Montivero, Luciana; Lacunza, Ezequiel; Argibay, María Cecilia; Abba, Martín; Furlong, Laura I., 1971-; Colas, Eva; Gil-Moreno, Antonio; Reventós, Jaume; Bello, Ricardo; Vázquez-Levin, Mónica Hebe (Spandidos Publications, Ltd., 2020)
    Endometrial cancer (EC) is the sixth most common cancer in women worldwide. Early diagnosis is critical in recurrent EC management. The present study aimed to identify biomarkers of EC early recurrence using a workflow ...
  • Tian, Tian V.; Vidal Ocabo, Enrique; Graf, T. (Thomas); Stik, Grégoire (MyJove Corporation, 2020)
    During mammalian development, cell fates are determined through the establishment of regulatory networks that define the specificity, timing, and spatial patterns of gene expression. Embryoid bodies (EBs) derived from ...
  • Bogaerts Márquez, María (2022-01-19)
    Entender cómo las especies se adaptan al ambiente es aún una pregunta sin resolver en el campo de la Biología Evolutiva. Mientras el foco principal siempre ha estado en la base genética, los factores ambientales responsables ...
  • Prasad, Aparna; Rabionet, Raquel; Espinet Solà, Blanca; Zapata Ortiz, Luis, 1985-; Puiggros Metje, Anna Maria; Melero Vilella, Maria Carme; Puig, Anna; Sarria-Trujillo, Yaris; Ossowski, Stephan; Garcia-Muret, Maria P.; Estrach, Teresa; Servitje, Octavio; Lopez-Lerma, Ingrid; Gallardo Hernández, Fernando; Pujol Vallverdú, Ramon Maria; Estivill, Xavier, 1955- (Elsevier, 2016)
    Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma with an aggressive clinical course. The genetic etiology of the disease is poorly understood, with chromosomal abnormalities and mutations in some genes being ...
  • Pavlovic, Milica (Universitat Pompeu Fabra, 2016-06-16)
    El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, modelos experimentales ...
  • Puigdevall Costa, Pau (Universitat Pompeu Fabra, 2019-02-20)
    Understanding the molecular basis of human inherited disease is a challenging task due to the complexity of mapping the genotype to the phenotype. The study of diseases running in families has shown that the inheritance ...
  • Monlong, Jean; Calvo, Miquel (Calvo Llorca); Ferreira, Pedro G.; Guigó Serra, Roderic (Nature Publishing Group, 2014)
    Identification of genetic variants affecting splicing in RNA sequencing population studies is still in its infancy. Splicing phenotype is more complex than gene expression and ought to be treated as a multivariate phenotype ...
  • Abner, Erik (Universitat Pompeu Fabra, 2018-05-22)
    Tras la infección por VIH-1, el establecimiento de un depósito de células T en reposo infectadas latentemente con VIH impide la erradicación del virus en pacientes. Para lograr la erradicación, la terapia retroviral existente ...
  • Velten, Lars; Story, Benjamin A.; Hernández-Malmierca, Pablo; Raffel, Simon; Leonce, Daniel R.; Milbank, Jennifer; Paulsen, Malte; Demir, Aykut; Szu-Tu, Chelsea; Frömel, Robert; Lutz, Christoph; Novak, Daniel; Jann, Johann-Christoph; Pabst, Caroline; Boch, Tobias; Hofmann, Wolf-Karsten; Müller-Tidow, Carsten; Trumpp, Andreas; Haas, Simon; Steinmetz, Lars M. (Nature Research, 2021)
    Cancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization of these cells remains elusive and with it the ability to eradicate cancer at its source. In acute ...
  • Cava, Claudia; Armaos, Alexandros, 1989-; Lang, Benjamin; Tartaglia, Gian Gaetano; Castiglioni, Isabella (Nature Research, 2022)
    Breast cancer is a heterogeneous disease classified into four main subtypes with different clinical outcomes, such as patient survival, prognosis, and relapse. Current genetic tests for the differential diagnosis of BC ...
  • Sánchez, Ariadna; Hernandez, Goretti; Iglesias Coma, Mar; Moreira, Leticia (MDPI, 2021)
    Background: Small bowel adenocarcinoma (SBA) is a rare disease which can be associated with Lynch syndrome (LS). LS tumors are characterized by the presence of microsatellite instability (MSI) and/or the loss of mismatch ...

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