Browsing by Author "Real, Francisco X."

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  • Aguilar Izquierdo, Susana (Universitat Pompeu Fabra, 2011-04-12)
    Exocrine pancreatic cancer is the fifth leading cause of death from malignant disease in Western society and it is one of the most aggressive human tumors. Once diagnosed, the 12-month patient survival is less than 5%. ...
  • Garcia-Carbonero, Rocio; Real, Francisco X.; Salazar, Ramón (BMJ Publishing Group, 2022)
    Background: VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral spread and facilitate chemotherapy and ...
  • Martín-Sánchez, Esperanza; Real, Francisco X.; Piris, Miguel A. (Public Library of Science (PLoS), 2014)
    Currently, there is no efficient therapy for patients with peripheral T cell lymphoma (PTCL). The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important mediators of cell survival. We aimed ...
  • Yu, Jingru; Ploner, Alexander; Kordes, Maximilian; Löhr, J. Matthias; Nilsson, Magnus; López De Maturana, Evangelina; Estudillo, Lidia; Renz, Harald; Carrato, Alfredo; Molero, Xavier; Real, Francisco X.; Malats i Riera, Núria; Ye, Weimin (Wiley, 2021)
    Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 ...
  • Cantor, Kenneth P; Villanueva Belmonte, Cristina; Silverman, Debra T.; Figueroa, Jonine D.; Real, Francisco X.; García Closas, Montserrat; Malats i Riera, Núria; Chanock, Stephen J.; Yeager, Meredith; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Castaño Vinyals, Gemma; Samanic, Claudine; Rothman, Nathaniel; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2010)
    Background: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.Objectives: In this study we investigated the combined influence of DBP exposure and polymorphisms in ...
  • López De Maturana, Evangelina; Picornell, Antoni; Masson-Lecomte, Alexandra; Kogevinas, Manolis; Márquez, Mirari; Carrato, Alfredo; Tardón, Adonina; Lloreta Trull, Josep, 1958-; García Closas, Montserrat; Silverman, Debra T.; Rothman, Nathaniel; Chanock, Stephen J.; Real, Francisco X.; Goddard, M. E.; Malats i Riera, Núria; SBC/EPICURO Study Investigators (BioMed Central, 2016)
    BACKGROUND: We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to ...
  • Font, Albert; Doménech, Montserrat; Ramirez, Jose Luis; Marqués, Miriam; Benítez, Raquel; Ruiz de Porras, Vicenç; Gago, José L.; Carrato, Cristina; Sant, Francesc; López, Héctor; Castellano, Daniel; Malats i Riera, Núria; Calle, M. Luz; Real, Francisco X. (Frontiers, 2023)
    Background and objective: Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no ...
  • Martínez de Villarreal, Jaime; Kalisz, Mark; Piedrafita, Gabriel; Graña-Castro, Osvaldo; Chondronasiou, Dafni; Serrano, Manuel; Real, Francisco X. (Oxford University Press, 2023)
    Transposable elements (TE) have played a major role in configuring the structures of mammalian genomes through evolution. In normal conditions, the expression of these elements is repressed by different epigenetic regulation ...
  • Vedder, Moniek M.; Márquez, Mirari; De Bekker-Grob; Calle, M. Luz; Dyrskjøt, Lars; Kogevinas, Manolis; Segersten, Ulrika; Malmström, Per-Uno; Algaba, Ferran; Beukers, Willemien; Orntoft, Torben F.; Zwarthoff, Ellen; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Objective: We aimed to determine the validity of two risk scores for patients with non-muscle invasive bladder cancer in different European settings, in patients with primary tumours. Methods: We included 1,892 patients ...
  • Richart, Laia; Lapi, Eleonora; Pancaldi, Vera; Cuenca-Ardura, Mirabai; Carrillo-de-Santa Pau, Enrique; Madrid-Mencía, Miguel; Neyret-Kahn, Hélène; Radvanyi, François; Rodríguez, Juan Antonio; Cuartero, Yasmina; Serra, François; Le Dily, François; Valencia, Alfonso; Martí Renom, Marc A.; Real, Francisco X. (Oxford University Press, 2021)
    Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, ...
  • van der Lelij, Petra; Lieb, Simone; Jude, Julian; Wutz, Gordana; Santos, Catarina P.; Falkenberg, Katrina; Schlattl, Andreas; Ban, Jozef; Schwentner, Raphaela; Hoffmann, Thomas; Kovar, Heinrich; Real, Francisco X.; Waldman, Todd; Pearson, Mark A.; Kraut, Norbert; Peters, Jan-Michael; Zuber, Johannes; Petronczki, Mark (eLife, 2017)
    Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a ...
  • Hruschka, Natascha; Andreu Martínez, David; Real, Francisco X.; Martinelli, Paola (Nature Research, 2020)
    As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a ...
  • Niell, Núria; Larriba, María Jesús; Ferrer Mayorga, Gemma; Sánchez Pérez, Isabel; Cantero, Ramón; Real, Francisco X.; Peso, Luis Del; Muñoz, Alberto; González Sancho, José Manuel (Wiley, 2018)
    Colorectal cancer results from the malignant transformation of colonic epithelial cells. Stromal fibroblasts are the main component of the tumour microenvironment, and play an important role in the progression of this and ...
  • Earl, Julie; Rico, Daniel; Carrillo, Enrique; Rodríguez Santiago, Benjamín; Méndez Pertuz, Marinela; Auer, Herbert; Gómez, Gonzalo; Barton Grossman, Herbert; Pisano, David G.; Schulz, Wolfgang; Pérez Jurado, Luis Alberto; Carrato, Alfredo; Theodorescu, Dan; Chanock, Stephen J.; Valencia, Alfonso; Real, Francisco X. (BioMed Central, 2015)
    Background. Urothelial bladder cancer is a highly heterogeneous disease. Cancer cell lines are useful tools for its study. This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines ...
  • López Knowles, Elena Cristina (Universitat Pompeu Fabra, 2011-04-12)
    El cáncer de vejiga es una enfermedad heterogénea. Los tumores se distribuyen en dos vías con cierto nivel de solapamiento: la vía papilar superficial caracterizada por alteraciones de FGFR3 y pérdida del cromosoma 9 y la ...
  • Santos, Catarina P.; Lapi, Eleonora; Martínez de Villarreal, Jaime; Álvaro-Espinosa, Laura; Fernández-Barral, Asunción; Barbáchano, Antonio; Domínguez, Orlando; Laughney, Ashley M.; Megías, Diego; Muñoz, Alberto; Real, Francisco X. (Nature Research, 2019)
    Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly ...
  • Fernández-Barral, Asunción; Costales-Carrera, Alba; Buira, Sandra P.; Jung, Peter; Ferrer Mayorga, Gemma; Larriba, María Jesús; Bustamante-Madrid, Pilar; Domínguez, Orlando; Real, Francisco X.; Guerra Pastrián, Laura; Lafarga, Miguel; García-Olmo, Damián; Cantero, Ramón; Del Peso, Luis; Batlle Gómez, Eduard; Rojo, Federico; Muñoz, Alberto; Barbáchano, Antonio (Wiley-Blackwell, 2019)
    Intestine is a major target of vitamin D and several studies indicate an association between vitamin D deficiency and inflammatory bowel diseases (IBD), but also increased colorectal cancer (CRC) risk and mortality. However, ...
  • Radvanyi, François; Real, Francisco X.; McConkey, David (IOS Press, 2023)
    In an accompanying paper, Mattias Hoglund discusses on what is a bladder cancer molecular subtype. He emphasizes the need to consider the aim of tumor classification, which is obviously critical to the approach. He also ...

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