Browsing by Author "Real, Francisco X."

Sort by: Order: Results:

  • Klein, Alison P.; Real, Francisco X.; Amundadottir, Laufey T. (Nature Publishing Group, 2018)
    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including ...
  • Moore, Lee E.; Pfeiffer, Ruth M.; Poscablo, Cristina; Real, Francisco X.; Kogevinas, Manolis; Silverman, Debra T.; García Closas, Reina; Chanock, Stephen J.; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; Dosemeci, Mustafa; García Closas, Montserrat; Esteller, Manel; Fraga, Mario F.; Rothman, Nathaniel; Malats i Riera, Núria (Elsevier, 2008)
    BACKGROUND: DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer. METHODS: ...
  • Kalisz, Mark; Bernardo, Edgar; Maestro, Miguel Ángel; Grau, Vanessa; Real, Francisco X.; Ferrer, Jorge (EMBO Press, 2020)
    Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encoding the transcription factor ...
  • Campos, Maria Luisa Morais Sarmento de (Universitat Pompeu Fabra, 2011-04-12)
    Ptf1a/p48 is a pancreas specific bHLH transcription factor that is required at early stages of embryonic development for pancreas formation and, during adulthood, for the proper exocrine pancreatic function. P48 also exerts ...
  • Font, Albert; Doménech, Montserrat; Benítez, Raquel; Rava, Marta; Marqués, Miriam; Ramírez, José L.; Pineda, Silvia; Domínguez Rodríguez, Miriam; Gago, José L.; Badal, Josep; Carrato, Cristina; López, Héctor; Quer, Ariadna; Castellano, Daniel; Malats i Riera, Núria; Real, Francisco X. (MDPI, 2020)
    Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors ...
  • Pineda, Silvia; Real, Francisco X.; Kogevinas, Manolis; Carrato, Alfredo; Chanock, Stephen J.; Malats i Riera, Núria; Van Steen, Kristel (Public Library of Science, 2015)
    Omics data integration is becoming necessary to investigate the genomic mechanisms involved in complex diseases. During the integration process, many challenges arise such as data heterogeneity, the smaller number of ...
  • Menashe, Idan; Real, Francisco X.; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Rothman, Nathaniel (Public Library of Science (PLoS), 2012)
    Pathway analysis of genome-wide association studies (GWAS) offer a unique opportunity to collectively evaluate genetic variants with effects that are too small to be detected individually. We applied a pathway analysis to ...
  • Salas, Lucas A.; Villanueva Belmonte, Cristina; Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Moore, Lee E.; Carrato, Alfredo; Tardón, Adonina; Serra, Consol; García Closas, Reina; Basagaña Flores, Xavier; Rothman, Nathaniel; Silverman, Debra T.; Cantor, Kenneth P; Kogevinas, Manolis; Real, Francisco X.; Fraga, Mario F.; Malats i Riera, Núria (Taylor & Francis (Routledge), 2014)
    DNA methylation changes contribute to bladder carcinogenesis. Trihalomethanes (THM), a class of disinfection by-products, are associated with increased urothelial bladder cancer (UBC) risk. THM exposure in animal models ...
  • Amaral, André F.S.; Tajuddin, Salman Muhammad; Fernández, Agustín F.; Chanock, Stephen J.; Silverman, Debra T.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Jackson, Brian P.; Toraño, Estela; Márquez, Miriam; González Urdinguio, Rocío; García Closas, Reina; Rothman, Nathaniel; Kogevinas, Manolis; Real, Francisco X.; Fernández Fraga, Mario; Malats i Riera, Núria (Cancer Research UK, 2014)
    Background: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation ...
  • Zhou, W.; Real, Francisco X.; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Chanock, Stephen J. (Nature Publishing Group, 2016)
    Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts ...
  • Rodríguez Santiago, Benjamín; Malats i Riera, Núria; Rothman, Nathaniel; Armengol i Dulcet, Lluís; García Closas, Montserrat; Kogevinas, Manolis; Villa, Olaya; Hutchinson, Amy; Earl, Julie; Marenne, Gaëlle; Jacobs, Kevin; Rico, Daniel; Tardón, Adonina; Carrato, Alfredo; Thomas, Gilles; Valencia, Alfonso; Silverman, Debra T.; Real, Francisco X.; Chanock, Stephen J.; Pérez Jurado, Luis Alberto (Elsevier, 2010)
    Mosaicism is defined as the coexistence of cells with different genetic composition within an individual, caused by postzygotic somatic mutation. Although somatic mosaicism for chromosomal abnormalities is a well-established ...
  • Rovira Clusellas, Meritxell; Delaspre, Fabien; Massumi, Mohammad; Serra Pascual, Selma A., 1981-; Valverde, M. A. (Miguel Ángel), 1963-; Lloreta Trull, Josep, 1958-; Dufresne, Marlène; Payré, Bruno; Konieczny, Stephen F.; Savatier, Pierre; Real, Francisco X.; Skoudy, Anouchka (Elsevier, 2008)
    Background & Aims: Acinar cells constitute 90% of the pancreas epithelium, are polarized, and secrete digestive enzymes. These cells play a crucial role in pancreatitis and pancreatic cancer. However, there are limited ...
  • Piedrafita, Gabriel; Fernández, Luis; Real, Francisco X. (IOS Press, 2020)
    Bladder cancer is characterized by high rates of recurrence and multifocality, features which have commonly been associated with the colonization of widespread areas of non-neoplastic urothelium by mutant cells, a phenomenon ...
  • García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Castaño Vinyals, Gemma; Torà, Montserrat; Fernández-Avilés, Francisco; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    BACKGROUND: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    Background: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • Melendez, Elena; Chondronasiou, Dafni; Mosteiro, Lluc; Martínez de Villarreal, Jaime; Fernández-Alfara, Marcos; Lynch, Cian J.; Grimm, Dirk; Real, Francisco X.; Alcamí, José; Climent, Núria; Pietrocola, Federico; Serrano, Manuel (Company of Biologists, 2022)
    The ectopic expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo ...
  • Cobo, Isidoro; Paliwal, Sumit; Bodas, Cristina; Felipe, Irene; Melià-Alomà, Júlia; Torres, Ariadna; Martínez-Villarreal, Jaime; Malumbres, Marina; García, Fernando; Millán, Irene; Pozo, Natalia del; Park, Joo-Cheol; MacDonald, Ray J.; Muñoz, Javier; Méndez, Raúl; Real, Francisco X. (Nature Research, 2023)
    Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites are enriched ...
  • Pinho, Andreia V. (Universitat Pompeu Fabra, 2011-09-30)
    Pancreatic acinar cells display plasticity to acquire distinct differentiation programs, being involved in diseases as chronic pancreatitis and pancreatic ductal adenocarcinoma. This work shows that acinar cells cultured ...
  • Amaral, André F.S.; Porta Serra, Miquel; Silverman, Debra T.; Milne, Roger L.; Kogevinas, Manolis; Rothman, Nathaniel; Cantor, Kenneth P; Jackson, Brian P.; Pumarega Rodríguez, José Antonio; López, Tomàs; Carrato, Alfredo; Guarner, Luisa; Real, Francisco X.; Malats i Riera, Núria (BMJ Publishing Group, 2012)
    Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously ...
  • Cáceres, Marta; Quesada Diez, Rita; Iglesias, Mar; Real, Francisco X.; Villamonte, Maria; Martínez de Villarreal, Jaime; Pérez, Mónica; Andaluz, Anna; Moll, Xavier; Berjano, Enrique J.; Dorcaratto, Dimitri; Sánchez Velázquez, Patricia, 1985-; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Research, 2020)
    Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This study describes ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking