Browsing by Author "Molinuevo, José Luis"

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  • Sanromà, Gerard; Benkarim, Oualid M.; Piella Fenoy, Gemma; Camara, Oscar; Wu, Guorong; Shen, Dinggang; Gispert López, Juan Domingo; Molinuevo, José Luis; González Ballester, Miguel Ángel, 1973- (Elsevier, 2018)
    In brain structural segmentation, multi-atlas strategies are increasingly being used over single-atlas strategies because of their ability to fit a wider anatomical variability. Patch-based label fusion (PBLF) is a type ...
  • Gascon Merlos, Mireia, 1984-; Sánchez Benavides, Gonzalo; Dadvand, Payam; Martínez, David; Gramunt Fombuena, Nina; Gotsens, Xavier; Cirach, Marta; Vert Roca, Cristina, 1991-; Molinuevo, José Luis; Crous-Bou, Marta; Nieuwenhuijsen, Mark J. (Elsevier, 2018)
    Background: Although exposure to natural outdoor environments has been consistently associated with improved perceived general health, available evidence on a protective association between this exposure and specific mental ...
  • Casamitjana, Adrià; Vilaplana, Verónica; Puch, Santi; Aduriz, Asier; López, Carlos; Operto, Grégory; Cacciaglia, Raffaele; Falcón, Carles; Molinuevo, José Luis; Domingo Gispert, Juan; Alzheimer’s Disease Neuroimaging Initiative (SpringerOpen, 2021)
    NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. ...
  • Martí Juan, Gerard; Sanromà, Gerard; Cacciaglia, Raffaele; Falcón, Carles; Operto, Grégory; Molinuevo, José Luis; González Ballester, Miguel Ángel, 1973-; Domingo Gispert, Juan; Piella Fenoy, Gemma; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Wiley, 2020)
    The ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including ...
  • Suárez-Calvet, Marc; Milà Alomà, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Minguillón, Carolina; Shekari, Mahnaz; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Sala Vila, Aleix; González de Echávarri, José Maria; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was ...
  • Brugulat Serrat, Anna, 1986-; Salvadó, Gemma; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Springer, 2019)
    White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and ...
  • Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Ashton, Nicholas J.; Suárez-Calvet, Marc; Heslegrave, Amanda; Hye, Abdul; Razquin, Cristina; Pastor, Pau; Sanchez-Valle, Raquel; Molinuevo, José Luis; Visser, Pieter Jelle; Blennow, Kaj; Hodges, Angela K.; Zetterberg, Henrik (BioMed Central, 2019)
    Background: Results from recent clinical studies suggest that cerebrospinal fluid (CSF) biomarkers that are indicative of Alzheimer's disease (AD) can be replicated in blood, e.g. amyloid-beta peptides (Aβ42 and Aβ40) and ...
  • Petrone, Paula M.; Casamitjana, Adrià; Falcón, Carles; Artigues, Miquel; Operto, Grégory; Cacciaglia, Raffaele; Molinuevo, José Luis; Vilaplana, Verónica; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)
    Background: Magnetic resonance imaging (MRI) has unveiled specific alterations at different stages of Alzheimer's disease (AD) pathophysiologic continuum constituting what has been established as "AD signature". To what ...
  • Akinci, Muge; Peña-Gómez, Cleofé; Operto, Grégory; Fuentes-Julian, Sherezade; Deulofeu, Carme; Sánchez Benavides, Gonzalo; Milà Alomà, Marta; Grau-Rivera, Oriol; Gramunt Fombuena, Nina; Navarro i Cuartiellas, Arcadi, 1969-; Minguillón, Carolina; Fauria, Karine; Suridjan, Ivonne; Kollmorgen, Gwendlyn; Bayfield, Anna; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; Arenaza-Urquijo, Eider M.; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer disease (AD), which may accelerate disease progression. We investigated whether β-amyloid, cortical ...
  • Wolfsgruber, Steffen; Molinuevo, José Luis; Euro-SCD working group (BioMed Central, 2019)
    Introduction: Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and as a target population for future ...
  • Forcano, Laura; Fauria, Karine; Soldevila-Domenech, Natalia; Minguillón, Carolina; Lorenzo, Thais; Cuenca Royo, Aida Ma, 1981-; Menezes Cabral, Sofia; Pizarro Lozano, Mª Nieves; Boronat Rigol, Anna, 1990-; Molinuevo, José Luis; Torre Fornell, Rafael de la; PENSA Study Group (Wiley, 2021)
    Introduction: Subjects exhibiting subjective cognitive decline (SCD) are at an increased risk for mild cognitive impairment and dementia. Given the delay between risk exposure and disease onset, SCD individuals are ...
  • Lopes Alves, Isadora; Gispert López, Juan Domingo; Molinuevo, José Luis; AMYPAD Consortium (Wiley, 2020)
    Introduction: The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) Prognostic and Natural History Study (PNHS) aims at understanding the role of amyloid imaging in the earliest stages of Alzheimer's disease (AD). ...
  • Sánchez Benavides, Gonzalo; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Milà Alomà, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Crous-Bou, Marta; Niñerola-Baizán, Aida; Perissinotti, Andrés; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) ...
  • Falcon, Carles; Navarro-Plaza, Mari Carmen; Gramunt Fombuena, Nina; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Cacciaglia, Raffaele; González de Echávarri, José Maria; Sanchez-Benavides, Gonzalo; Operto, Grégory; Knezevic, Iva; Molinuevo, José Luis; Domingo Gispert, Juan (Elsevier, 2022)
    Most people have a soundtrack of life, a set of special musical pieces closely linked to certain biographical experiences. Autobiographical memories (AM) and music listening (ML) involve complex mental processes ruled by ...
  • Salvadó, Gemma; Brugulat Serrat, Anna, 1986-; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2019)
    Background: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH associated with dementia ...
  • Cortés Canteli, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Toribio Fernández, Raquel; Tristão Pereira, Catarina; Falcón, Carles; Oliva, Belén; Mendiguren, José; Fernández Friera, Letícia; Sanz, Javier; García-Ruiz de Morales, José María; Fernández Ortiz, Antonio; Sánchez González, Javier; Ibáñez, Borja; Molinuevo, José Luis; Fuster, Valentín (Elsevier, 2021)
    Background: Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains ...
  • Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...
  • Molinuevo, José Luis; Gramunt Fombuena, Nina; Domingo Gispert, Juan; Fauria, Karine; Esteller, Manel; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Huesa, Gema; Morán, Sebastián; Dal-Ré, Rafael; Camí, Jordi, 1952- (Elsevier, 2016)
    Introduction: The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA ...
  • Collij, Lyduine E.; Salvadó, Gemma; Shekari, Mahnaz; Lopes Alves, Isadora; Reimand, Juhan; Wink, Alle Meije; Zwan, Marissa; Niñerola-Baizán, Aida; Perissinotti, Andrés; Scheltens, Philip; Ikonomovic, Milos D.; Smith, Adrian P.L.; Farrar, Gill; Molinuevo, José Luis; Barkhof, Frederik; Buckley, Christopher, 1948-; van Berckel, Bart N. M. (Springer, 2021)
    Purpose: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods: [18F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were ...

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