Browsing by Author "García de Herreros, Antonio"

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  • Viñas Castells, Rosa, 1985-; Frías Hernández, Àlex, 1985-; Robles Lanuza, Estefanía; Zhang, Kun; Longmore, Gregory D; García de Herreros, Antonio; Díaz, Víctor M. (Oxford University Press, 2014)
    The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ...
  • Loubat Casanovas, Jordina (Universitat Pompeu Fabra, 2015-12-15)
    Programa de doctorat en Biomedicina
  • Rodríguez, María Isabel; Peralta-Leal, Andreína; O'Valle, Francisco; Rodríguez-Vargas, José Manuel; González-Flores, Ariannys; Majuelos-Melguizo, Jara; López Muñoz, Laura; Serrano, Santiago; García de Herreros, Antonio; Rodríguez-Manzaneque, Juan Carlos; Fernández Montes, Rubén D.; del Moral, Raimundo G.; de Almodovar, José Mariano; Oliver, F. Javier (Public Library of Science (PLoS), 2013)
    PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- or radiotherapy in various tumor settings; however, the basis for the anti-metastasic activities resulting from PARP ...
  • Mateu Jiménez, Mercè, 1990-; Fermoselle Pérez, Clara, 1985-; Rojo, Federico; Mateu de Antonio, Francisco Javier; Peña, Raúl; Urtreger, Alejandro J.; Diament, Miriam J.; Joffé, Elisa D. Bal de Kier; Pijuan Andujar, Lara; García de Herreros, Antonio; Barreiro Portela, Esther (Bentham Science Publishers, 2016)
    Lung cancer (LC) remains the leading cause of cancer mortality worldwide, and non-small cell LC (NSCLC) represents 80% of all LC. Oxidative stress and inflammation, autophagy, ubiquitin-proteasome system, nuclear factor ...
  • Pérez-Moreno, Pablo; Quezada-Meza, Camila; Chavez-Almarza, Cristopher; Niechi, Ignacio; Silva-Pavez, Eduardo; Trigo-Hidalgo, César; Aguayo, Francisco; Jara, Lilian; Cáceres-Verschae, Albano; Varas-Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Verónica A.; Tapia, Julio C. (Frontiers, 2020)
    Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ...
  • Puig Borreil, Isabel (Universitat Pompeu Fabra, 2011-04-12)
    El mal pronòstic en una neoplàsia epitelial està associada a l'adquisició de característiques mòbils o invasives per part de les cèl·lules canceroses. Aquesta transformació morfològica es denomina transició epiteli-mesènquima ...
  • Millanes Romero, Alba, 1986-; Herranz Martín, Nicolás; Perrera, Valentina; Iturbide Martínez de Albéniz, Ane, 1989-; Loubat Casanovas, Jordina, 1982-; Jenuwein, Thomas; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2013)
    Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of ...
  • Cortina Duran, Carme (Universitat Pompeu Fabra, 2011-09-08)
    In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin ...
  • Batlle Gómez, Raquel (Universitat Pompeu Fabra, 2012-02-16)
    The Snail1 transcriptional repressor is a key factor responsible in triggering epithelial to mesenchymal transition. Although Snail1 is widely expressed in early development, it is limited in adult animals to a subset of ...
  • Farfán, Nancy; Orellana Serradell, Octavio; Herrera, Daniela; Chrzanowsky, Dominique; Cubillos, Paulina; Marín, Gabriel; García de Herreros, Antonio; Castellón, Enrique A.; Contreras, Héctor R. (Spandidos Publications, Ltd., 2020)
    Zinc finger protein SNAI1 (SNAIL) and zinc finger protein SNAI2 (SLUG) transcription factors promote epithelial‑mesenchymal transition, a process through which epithelial cells acquire a mesenchymal phenotype, increasing ...
  • Gonzàlez Busqué, Núria (Universitat Pompeu Fabra, 2018-10-16)
    Snail1 transcription factor is the key inducer of epithelial-to-mesenchymal transition (EMT). Here, we describe a novel role for Snail1 on the regulation of telomere integrity and transcription as well as telomerase ...
  • Cabrerizo Granados, David, 1993-; Peña Arranz, Raúl, 1976-; Palacios, Laura; Carrillo-Bosch, Laura; Lloreta-Trull, Josep; Comerma Blesa, Laura, 1983-; Iglesias Coma, Mar; García de Herreros, Antonio (Ivyspring International Publisher, 2021)
    Snail1 is a transcriptional factor required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). Apart from that, tumor endothelial cells also express Snail1. Here, we have unraveled ...
  • Alba Castellón, Lorena (Universitat Pompeu Fabra, 2017-06-14)
    Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that the function of ...
  • Alba-Castellón, Lorena; Batlle, Raquel; Francí, Clara; Fernández Aceñero, María Jesús; Mazzolini, Rocco; Peña, Raúl; Loubat, Jordina; Alameda Quitllet, Francisco; Rodríguez, Rufo; Curto, Josué; Albanell, Joan; Muñoz, Alberto; Bonilla, Félix; Casal, José Ignacio; Rojo, Federico; García de Herreros, Antonio (Elsevier, 2014)
    Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of ...
  • Loubat Casanovas, Jordina, 1982-; Peña, Raúl; Gonzàlez Busqué, Núria, 1980-; Alba Castellón, Lorena, 1984-; Rosell, Santi; Francí i Carreté, Clara; Navarro Medrano, Pilar; García de Herreros, Antonio (Impact Journals, 2016)
    The Snail1 transcriptional factor is required for correct embryonic development, yet its expression in adult animals is very limited and its functional roles are not evident. We have now conditionally inactivated Snail1 ...
  • Mazzolini, Rocco; Gonzàlez Busqué, Núria, 1980-; Garcia-Garijo, Andrea; Millanes Romero, Alba, 1986-; Peiró Sales, Sandra; Smith, Susan; García de Herreros, Antonio; Canudas i Puig, Sílvia (Oxford University Press, 2018)
    Besides controlling epithelial-to-mesenchymal transition (EMT) and cell invasion, the Snail1 transcriptional factor also provides cells with cancer stem cell features. Since telomere maintenance is essential for stemness, ...
  • Baulida i Estadella, Josep, 1965-; García de Herreros, Antonio (Elsevier, 2015)
    The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT) in tumor epithelial cells, a process associated with the emergence of stemness, invasion and cancer malignancy. Here, we review recent ...
  • Baulida i Estadella, Josep, 1965-; Díaz Cortés, Víctor Manuel, 1956-; García de Herreros, Antonio (MDPI, 2019)
    Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene ...
  • Beltran, Manuel; Aparicio i Prat, Estel, 1986-; Mazzolini, Rocco; Millanes Romero, Alba, 1986-; Massó, Pere; Jenner, Richard G.; Díaz, Víctor M.; Peiró Sales, Sandra; García de Herreros, Antonio (Oxford University Press, 2015)
    In this report we have analyzed the role of antisense transcription in the control of LEF1 transcription factor expression. A natural antisense transcript (NAT) is transcribed from a promoter present in the first intron ...
  • Lambies Barjau, Guillem, 1990-; Miceli, Martina; Martínez-Guillamon, Catalina; Olivera-Salguero, Rubén; Peña, Raúl; Frías, Carolina-Paola; Calderón, Irene; Atanassov, Boyko S.; Dent, Sharon Y.R.; Arribas, Joaquín; García de Herreros, Antonio; Díaz Cortés, Víctor Manuel, 1956- (American Association for Cancer Research (AACR), 2019)
    In cancer cells, epithelial-to-mesenchymal transition (EMT) is controlled by Snail1, a transcriptional factor also required for the activation of cancer-associated fibroblasts (CAF). Snail1 is short-lived in normal epithelial ...

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