Browsing by Author "Bustamante Pineda, Mariona"

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  • The Human Early-Life Exposome (HELIX): project rationale and design
    Vrijheid, Martine; Robinson, Oliver; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; van Gent, Diana; González Ruiz, Juan Ramón; Júlvez Calvo, Jordi; Kogevinas, Manolis; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2014)
    Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure–health effect relationships. The ...
  • Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children's blood
    Ruiz-Arenas, Carlos; Hernandez-Ferrer, Carles, 1987-; Vives Usano, Marta, 1990-; Marí, Sergi; Casas Sanahuja, Maribel; Vafeiadi, Marina, 1983-; Vrijheid, Martine; González Ruiz, Juan Ramón; Bustamante Pineda, Mariona (eLife Sciences Publications, 2022)
    Background: The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA methylation levels and gene expression, might help the biological interpretation of epigenome-wide ...
  • Importance of considering circadian rhythm in the design of in vivo transcriptional studies of acute effects of environmental exposures: Commentary to "The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD3" published in Environmental Research 2017 Nov:159:239-248. doi: 10.1016/j.envres.2017.07.045
    Bustamante Pineda, Mariona; Wucher, Valentin; Young, Antony R. (Elsevier, 2019)
  • In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
    Vives Usano, Marta, 1990-; Hernández-Ferrer, Carles; Maitre, Léa; Ruiz Arenas, Carlos, 1990-; Borràs, Eva; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; González, Juan Ramón; Sabidó Aguadé, Eduard, 1981-; Vrijheid, Martine; Bustamante Pineda, Mariona (BioMed Central, 2020)
    Background: The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only ...
  • In utero exposure to mixtures of xenoestrogens and child neuropsychological development
    Vilahur Chiaraviglio, Nadia, 1982-; Fernandez, Mariana F.; Bustamante Pineda, Mariona; Ramos, Rosa; Forns i Guzman, Joan, 1981-; Ballester Díez, Ferran; Murcia, Mario; Riaño, Isolina; Ibarluzea, Jesús; Olea, Nicolás; Sunyer Deu, Jordi (Elsevier, 2014)
    BACKGROUND: To date, no epidemiological studies have explored the impact and persistence of in utero exposure to mixtures of xenoestrogens on the developing brain. We aimed to assess whether the cumulative effect of ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
    Merid, Simon Kebede; Bustamante Pineda, Mariona; Standl, Marie; Sunyer Deu, Jordi; Heinrich, Joachim; Lemonnier, Nathanael; Aguilar, Daniel; Antó i Boqué, Josep Maria; Bousquet, Jean; Santa Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Elsevier, 2020)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Interaction between airborne copper exposure and ATP7B polymorphisms on inattentiveness in scholar children
    Alemany, Silvia; Vilor-Tejedor, Natàlia; Bustamante Pineda, Mariona; Álvarez Pedrerol, Mar, 1981-; Rivas, Ioar; Forns i Guzman, Joan, 1981-; Querol, Xavier; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi (Elsevier, 2017)
    Recent research indicates that airborne copper exposure in scholar children negatively affects brain functioning. These effects are likely to be influenced by the efficiency of copper metabolism, which is partly regulated ...
  • Maternal and fetal genetic contribution to gestational weight gain
    Warrington, Nicole M.; Espinosa Díaz, Ana; Guxens Junyent, Mònica; Kogevinas, Manolis; Bustamante Pineda, Mariona; Lawlor, Debbie A. (Nature Research, 2018)
    Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes ...
  • Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile
    Rubio, Rocío; Aguilar, Ruth; Bustamante Pineda, Mariona; Muñoz, Erica; Vázquez-Santiago, Miquel; Santano, Rebeca; Vidal, Marta; Rodrigo Melero, Natalia; Parras, Daniel; Serra, Pau; Santamaria, Pere; Carolis, Carlo; Izquierdo, Luis; Gómez-Roig, María Dolores; Dobaño, Carlota; Moncunill, Gemma; Mazarico, Edurne (Frontiers, 2022)
    SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant women and have a higher risk of adverse pregnancy outcomes like intrauterine/fetal distress and preterm birth. However, little ...
  • Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
    Ronkainen, Justiina; Vives Usano, Marta, 1990-; Guxens Junyent, Mònica; Vrijheid, Martine; Bustamante Pineda, Mariona; Sebert, Sylvain (Taylor & Francis, 2022)
    Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by ...
  • Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
    Küpers, Leanne K.; Fernández-Barrés, Sílvia; Nounu, Aayah; Friedman, Chloe; Fore, Ruby; Mancano, Giulia; Dabelea, Dana; Rifas-Shiman, Sheryl L.; Mulder, Rosa H.; Oken, Emily; Johnson, Laura; Bustamante Pineda, Mariona; Jaddoe, Vincent W. V.; Hivert, Marie-France; Starling, Anne P.; de Vries, Jeanne H. M.; Sharp, Gemma C.; Vrijheid, Martine; Felix, Janine Frédérique (Taylor & Francis, 2022)
    Higher adherence to the Mediterranean diet during pregnancy is related to a lower risk of preterm birth and to better offspring cardiometabolic health. DNA methylation may be an underlying biological mechanism. We evaluated ...
  • Mendelian randomization analysis rules out disylipidaemia as colorectal cancer cause
    Ibáñez-Sanz, Gemma; Bustamante Pineda, Mariona; Castaño Vinyals, Gemma; Kogevinas, Manolis; Moreno, Víctor (Nature Research, 2019)
    Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian ...
  • Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
    Küpers, Leanne K.; Salas Díaz, Lucas Andrés, 1980-; Bustamante Pineda, Mariona; Kogevinas, Manolis; Vrijheid, Martine; Sunyer Deu, Jordi; Felix, Janine Frédérique (Nature Research, 2019)
    Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in ...
  • Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation
    Solomon, Olivia; González, Juan Ramón; Llambrich, Maria; Vives Usano, Marta, 1990-; Maitre, Léa; Foraster Pulido, Maria, 1984-; Kogevinas, Manolis; Bustamante Pineda, Mariona; Holland, Nina (Elsevier, 2022)
    Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and ...
  • Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
    Paternoster, Lavinia; Gonzalez, Juan Ramon; Bustamante Pineda, Mariona; Tejedor, Elisabeth; Sunyer Deu, Jordi; Weidinger, Stephan (Nature Research, 2015)
    Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, ...
  • Multi-omics signatures of the human early life exposome
    Maitre, Léa; Bustamante Pineda, Mariona; Hernández Ferrer, Carles; Vives Usano, Marta, 1990-; Ruiz-Arenas, Carlos; Pelegrí-Sisó, Dolors; Casas Sanahuja, Maribel; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; González, Juan Ramón; Vrijheid, Martine (Nature Research, 2022)
    Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) ...
  • A novel common variant in DCST2 is associated with length in early life and height in adulthood
    van der Valk, Ralf J.P.; Guxens Junyent, Mònica; EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium; Bustamante Pineda, Mariona; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (Oxford University Press, 2015)
    Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we ...
  • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
    Vogelezang, Suzanne; Vilor Tejedor, Natàlia, 1988-; Bustamante Pineda, Mariona; Vrijheid, Martine; Sunyer Deu, Jordi; Felix, Janine Frédérique (Public Library of Science (PLoS), 2020)
    The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...
  • Obesity is associated with shorter telomeres in 8 year-old children
    Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Gražulevičienė, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)
    Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
  • Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
    Everson, Todd M.; Vives Usano, Marta, 1990-; Sunyer Deu, Jordi; Bustamante Pineda, Mariona (Nature Research, 2021)
    Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations ...