Browsing by Author "Bigas Salvans, Anna"

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  • The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1
    Neves, Joana; Uchikawa, Masanori; Bigas Salvans, Anna; Giráldez, Fernando (Public Library of Science (PLoS), 2011)
    The proneural gene Atoh1 is crucial for the development of inner ear hair cells and it requires the function of the transcription factor Sox2 through yet unknown mechanisms. In the present work, we used the chicken embryo ...
  • Recent advances in T-cell lymphoid neoplasms
    Bigas Salvans, Anna; Rodríguez-Sevilla, Juan José; Espinosa Blay, Lluís; Gallardo Hernández, Fernando (Elsevier, 2022)
    T Cells comprise many subtypes of specified lymphocytes, and their differentiation and function take place in different tissues. This cellular diversity is also observed in the multiple ways T-cell transformation gives ...
  • Robustness of catalytically dead Cas9 activators in human pluripotent and mesenchymal stem cells
    Petazzi, Paolo; Torres-Ruiz, Raul; Fidanza, Antonella; Roca-Ho, Heleia; Gutierrez-Agüera, Francisco; Castaño, Julio; Rodríguez-Perales, Sandra; Diaz de la Guardia, Rafael; López-Millán, Belén; Bigas Salvans, Anna; Forrester, Lesley M.; Bueno, Clara; Menéndez, Pablo (Elsevier, 2020)
    Human pluripotent stem cells (hPSCs) and mesenchymal stromal/stem cells (hMSCs) are clinically relevant sources for cellular therapies and for modeling human development and disease. Many stem cell-based applications rely ...
  • Role of p27Kip1 as a transcriptional regulator
    Bachs Valldeneu, Oriol; Gallastegui Calvache, Edurne; Orlando, Serena; Bigas Salvans, Anna; Morante-Redolat, José Manuel; Serratosa, Joan; Fariñas, Isabel; Aligué, Rosa; Pujol, Maria Jesús (Impact Journal, 2018)
    The protein p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region into the catalytic cleave ...
  • Sézary syndrome patient-derived models allow drug selection for personalized therapy
    Gallardo Hernández, Fernando; Andrades, Evelyn; Iglesias, Arnau; González, Jessica; Solé, Laura; Guillén, Yolanda; Blanco Ares, Gonzalo, 1989-; Colomo Saperas, Luis Alberto; Gimeno Vázquez, Eva; Conde Estévez, David; Rodríguez, Eva; Bielsa-Marsol, Isabel; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria; Regueiro, José R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Society of Hematology, 2022)
    Current therapeutic approaches for Sézary syndrome (SS) do not achieve a significant improvement in long-term survival of patients, and they are mainly focused on reducing blood tumor burden to improve quality of life. ...
  • The EHA Research Roadmap: Normal hematopoiesis
    Jaffredo, Thierry; Bigas Salvans, Anna; Graf, T. (Thomas); Schuringa, Jan Jacob (Wolters Kluwer (LWW), 2021)
  • The evolution of relapse of adult T cell acute lymphoblastic leukemia
    Sentís, Inés; González, Santi; Genescà, Eulalia; García Hernández, Violeta; Muiños, Ferran; González, Celia; López Arribillaga, Erika, 1986-; González, Jessica; Fernández-Ibarrondo, Lierni; Mularoni, Loris; Espinosa-Anke, Luis; Bellosillo Paricio, Beatriz; Ribera, Josep Maria; Bigas Salvans, Anna; González Pérez, Abel; López Bigas, Núria (BioMed Central, 2020)
    Background: Adult T cell acute lymphoblastic leukemia (T-ALL) is a rare disease that affects less than 10 individuals in one million. It has been less studied than its cognate pediatric malignancy, which is more prevalent. ...
  • The multiple usages of Notch signaling in development, cell differentiation and cancer
    Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2018)
    Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate ...
  • The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation
    Vizán, Pedro; Gutiérrez, Arantxa; Espejo, Isabel; García Montolío, Marc, 1991-; Lange, Martin; Carretero, Ana; Lafzi, Atefeh; Andrés Aguayo, Luisa de; Blanco, Enrique; Thambyrajah, Roshana; Graf, T. (Thomas); Heyn, Holger; Bigas Salvans, Anna; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2020)
    Adult hematopoietic stem cells (HSCs) are rare multipotent cells in bone marrow that are responsible for generating all blood cell types. HSCs are a heterogeneous group of cells with high plasticity, in part, conferred by ...
  • Understanding the development of MLL-Rearranged leukemias : developing disease models
    Sinha, Roshani, 1989- (Universitat Pompeu Fabra, 2016-12-16)
    Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. They are also found in ...
  • Understanding the molecular mechanisms involved in Notch1 induced T-cell acute lymphoblastic leukemia
    D'Altri, Teresa, 1984- (Universitat Pompeu Fabra, 2013-07-26)
  • Unravelling new oncogenic functions of IKKα : towards a better understanding of colorectal carcinogenesis
    Colomer Montañà, Carlota (Universitat Pompeu Fabra, 2019-01-14)
    Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
  • Using pluripotent stem cells to understand normal and leukemic hematopoietic development
    Bigas Salvans, Anna; Galán i Palma, Luis; Kartha, Gayathri M.; Giorgetti, Alessandra (Oxford University Press, 2022)
    Several decades have passed since the generation of the first embryonic stem cell (ESC) lines both in mice and in humans. Since then, stem cell biologists have tried to understand their potential biological and clinical ...
  • β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia
    García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)
    Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...
  • β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.
    Gekas, Christos; Teresa, D'Altri 1984-; Aligué, Rosa; González, Jessica; Espinosa Blay, Lluís; Bigas Salvans, Anna (Nature Publishing Group, 2016)
    Notch activation is instrumental in the development of most T-cell acute lymphoblastic leukemia (T-ALL) cases, yet Notch mutations alone are not sufficient to recapitulate the full human disease in animal models. We here ...